Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease

Abstract Increasing evidence shows that metabolic abnormalities in body fluids are distinguishing features of the pathophysiology of Parkinson’s disease. However, a non-invasive approach has not been established in the earliest or pre-symptomatic phases. Here, we report comprehensive double-cohort a...

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Autores principales:	Shinji Saiki, Taku Hatano, Motoki Fujimaki, Kei-Ichi Ishikawa, Akio Mori, Yutaka Oji, Ayami Okuzumi, Takeshi Fukuhara, Takahiro Koinuma, Yoko Imamichi, Miho Nagumo, Norihiko Furuya, Shuko Nojiri, Taku Amo, Kazuo Yamashiro, Nobutaka Hattori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/39cf9e83253748d8b72eb80e81610158
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spelling	oai:doaj.org-article:39cf9e83253748d8b72eb80e816101582021-12-02T12:32:43ZDecreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease10.1038/s41598-017-06767-y2045-2322https://doaj.org/article/39cf9e83253748d8b72eb80e816101582017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06767-yhttps://doaj.org/toc/2045-2322Abstract Increasing evidence shows that metabolic abnormalities in body fluids are distinguishing features of the pathophysiology of Parkinson’s disease. However, a non-invasive approach has not been established in the earliest or pre-symptomatic phases. Here, we report comprehensive double-cohort analyses of the metabolome using capillary electrophoresis/liquid chromatography mass-spectrometry. The plasma analyses identified 18 Parkinson’s disease-specific metabolites and revealed decreased levels of seven long-chain acylcarnitines in two Parkinson’s disease cohorts (n = 109, 145) compared with controls (n = 32, 45), respectively. Furthermore, statistically significant decreases in five long-chain acylcarnitines were detected in Hoehn and Yahr stage I. Likewise, decreased levels of acylcarnitine(16:0), a decreased ratio of acylcarnitine(16:0) to fatty acid(16:0), and an increased index of carnitine palmitoyltransferase 1 were identified in Hoehn and Yahr stage I of both cohorts, suggesting of initial β-oxidation suppression. Receiver operating characteristic curves produced using 12–14 long-chain acylcarnitines provided a large area of under the curve, high specificity and moderate sensitivity for diagnosing Parkinson’s disease. Our data demonstrate that a primary decrement of mitochondrial β-oxidation and that 12–14 long-chain acylcarnitines decreases would be promising diagnostic biomarkers for Parkinson’s disease.Shinji SaikiTaku HatanoMotoki FujimakiKei-Ichi IshikawaAkio MoriYutaka OjiAyami OkuzumiTakeshi FukuharaTakahiro KoinumaYoko ImamichiMiho NagumoNorihiko FuruyaShuko NojiriTaku AmoKazuo YamashiroNobutaka HattoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shinji Saiki Taku Hatano Motoki Fujimaki Kei-Ichi Ishikawa Akio Mori Yutaka Oji Ayami Okuzumi Takeshi Fukuhara Takahiro Koinuma Yoko Imamichi Miho Nagumo Norihiko Furuya Shuko Nojiri Taku Amo Kazuo Yamashiro Nobutaka Hattori Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease
description	Abstract Increasing evidence shows that metabolic abnormalities in body fluids are distinguishing features of the pathophysiology of Parkinson’s disease. However, a non-invasive approach has not been established in the earliest or pre-symptomatic phases. Here, we report comprehensive double-cohort analyses of the metabolome using capillary electrophoresis/liquid chromatography mass-spectrometry. The plasma analyses identified 18 Parkinson’s disease-specific metabolites and revealed decreased levels of seven long-chain acylcarnitines in two Parkinson’s disease cohorts (n = 109, 145) compared with controls (n = 32, 45), respectively. Furthermore, statistically significant decreases in five long-chain acylcarnitines were detected in Hoehn and Yahr stage I. Likewise, decreased levels of acylcarnitine(16:0), a decreased ratio of acylcarnitine(16:0) to fatty acid(16:0), and an increased index of carnitine palmitoyltransferase 1 were identified in Hoehn and Yahr stage I of both cohorts, suggesting of initial β-oxidation suppression. Receiver operating characteristic curves produced using 12–14 long-chain acylcarnitines provided a large area of under the curve, high specificity and moderate sensitivity for diagnosing Parkinson’s disease. Our data demonstrate that a primary decrement of mitochondrial β-oxidation and that 12–14 long-chain acylcarnitines decreases would be promising diagnostic biomarkers for Parkinson’s disease.
format	article
author	Shinji Saiki Taku Hatano Motoki Fujimaki Kei-Ichi Ishikawa Akio Mori Yutaka Oji Ayami Okuzumi Takeshi Fukuhara Takahiro Koinuma Yoko Imamichi Miho Nagumo Norihiko Furuya Shuko Nojiri Taku Amo Kazuo Yamashiro Nobutaka Hattori
author_facet	Shinji Saiki Taku Hatano Motoki Fujimaki Kei-Ichi Ishikawa Akio Mori Yutaka Oji Ayami Okuzumi Takeshi Fukuhara Takahiro Koinuma Yoko Imamichi Miho Nagumo Norihiko Furuya Shuko Nojiri Taku Amo Kazuo Yamashiro Nobutaka Hattori
author_sort	Shinji Saiki
title	Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease
title_short	Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease
title_full	Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease
title_fullStr	Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease
title_full_unstemmed	Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease
title_sort	decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for parkinson’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/39cf9e83253748d8b72eb80e81610158
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Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease

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