Prognostic significance of bone marrow FDG uptake in patients with gynecological cancer

Abstract We investigated the prognostic significance and the underlying mechanism of increased bone marrow (BM) 2-(18F) fluoro-2-deoxy-D-glucose as a tracer (FDG)-uptake in patients with gynecological cancer. A list of patients diagnosed with cervical, endometrial, and ovarian cancer from January 20...

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Autores principales:	Kotaro Shimura, Seiji Mabuchi, Naoko Komura, Eriko Yokoi, Katsumi Kozasa, Tomoyuki Sasano, Mahiru Kawano, Yuri Matsumoto, Tadashi Watabe, Michiko Kodama, Kae Hashimoto, Kenjiro Sawada, Jun Hatazawa, Tadashi Kimura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/39d1a1b186164729a3bf828521cbeb26
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spelling	oai:doaj.org-article:39d1a1b186164729a3bf828521cbeb262021-12-02T14:16:49ZPrognostic significance of bone marrow FDG uptake in patients with gynecological cancer10.1038/s41598-021-81298-12045-2322https://doaj.org/article/39d1a1b186164729a3bf828521cbeb262021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81298-1https://doaj.org/toc/2045-2322Abstract We investigated the prognostic significance and the underlying mechanism of increased bone marrow (BM) 2-(18F) fluoro-2-deoxy-D-glucose as a tracer (FDG)-uptake in patients with gynecological cancer. A list of patients diagnosed with cervical, endometrial, and ovarian cancer from January 2008 to December 2014 were identified. Then, through chart reviews, 559 patients who underwent staging by FDG-positron emission tomography (PET)/computed tomography (CT) and subsequent surgical resection were identified, and their clinical data were reviewed retrospectively. BM FDG-uptake was evaluated using maximum standardized uptake value (SUVmax) and BM-to-aorta uptake ratio (BAR). As a result, we have found that increased BAR was observed in 20 (8.7%), 21 (13.0%), 21 (12.6%) of cervical, endometrial, and ovarian cancer, respectively, and was associated with significantly shorter survival. Increased BAR was also closely associated with increased granulopoiesis. In vitro and in vivo experiments revealed that tumor-derived granulocyte colony-stimulating factor (G-CSF) was involved in the underlying causative mechanism of increased BM FDG-uptake, and that immune suppression mediated by G-CSF-induced myeloid-derived suppressor cells (MDSCs) is responsible for the poor prognosis of this type of cancer. In conclusion, increased BM FDG-uptake, as represented by increased BAR, is an indicator of poor prognosis in patients with gynecological cancer.Kotaro ShimuraSeiji MabuchiNaoko KomuraEriko YokoiKatsumi KozasaTomoyuki SasanoMahiru KawanoYuri MatsumotoTadashi WatabeMichiko KodamaKae HashimotoKenjiro SawadaJun HatazawaTadashi KimuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kotaro Shimura Seiji Mabuchi Naoko Komura Eriko Yokoi Katsumi Kozasa Tomoyuki Sasano Mahiru Kawano Yuri Matsumoto Tadashi Watabe Michiko Kodama Kae Hashimoto Kenjiro Sawada Jun Hatazawa Tadashi Kimura Prognostic significance of bone marrow FDG uptake in patients with gynecological cancer
description	Abstract We investigated the prognostic significance and the underlying mechanism of increased bone marrow (BM) 2-(18F) fluoro-2-deoxy-D-glucose as a tracer (FDG)-uptake in patients with gynecological cancer. A list of patients diagnosed with cervical, endometrial, and ovarian cancer from January 2008 to December 2014 were identified. Then, through chart reviews, 559 patients who underwent staging by FDG-positron emission tomography (PET)/computed tomography (CT) and subsequent surgical resection were identified, and their clinical data were reviewed retrospectively. BM FDG-uptake was evaluated using maximum standardized uptake value (SUVmax) and BM-to-aorta uptake ratio (BAR). As a result, we have found that increased BAR was observed in 20 (8.7%), 21 (13.0%), 21 (12.6%) of cervical, endometrial, and ovarian cancer, respectively, and was associated with significantly shorter survival. Increased BAR was also closely associated with increased granulopoiesis. In vitro and in vivo experiments revealed that tumor-derived granulocyte colony-stimulating factor (G-CSF) was involved in the underlying causative mechanism of increased BM FDG-uptake, and that immune suppression mediated by G-CSF-induced myeloid-derived suppressor cells (MDSCs) is responsible for the poor prognosis of this type of cancer. In conclusion, increased BM FDG-uptake, as represented by increased BAR, is an indicator of poor prognosis in patients with gynecological cancer.
format	article
author	Kotaro Shimura Seiji Mabuchi Naoko Komura Eriko Yokoi Katsumi Kozasa Tomoyuki Sasano Mahiru Kawano Yuri Matsumoto Tadashi Watabe Michiko Kodama Kae Hashimoto Kenjiro Sawada Jun Hatazawa Tadashi Kimura
author_facet	Kotaro Shimura Seiji Mabuchi Naoko Komura Eriko Yokoi Katsumi Kozasa Tomoyuki Sasano Mahiru Kawano Yuri Matsumoto Tadashi Watabe Michiko Kodama Kae Hashimoto Kenjiro Sawada Jun Hatazawa Tadashi Kimura
author_sort	Kotaro Shimura
title	Prognostic significance of bone marrow FDG uptake in patients with gynecological cancer
title_short	Prognostic significance of bone marrow FDG uptake in patients with gynecological cancer
title_full	Prognostic significance of bone marrow FDG uptake in patients with gynecological cancer
title_fullStr	Prognostic significance of bone marrow FDG uptake in patients with gynecological cancer
title_full_unstemmed	Prognostic significance of bone marrow FDG uptake in patients with gynecological cancer
title_sort	prognostic significance of bone marrow fdg uptake in patients with gynecological cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/39d1a1b186164729a3bf828521cbeb26
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Prognostic significance of bone marrow FDG uptake in patients with gynecological cancer

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