Protecting the Ocular Surface in Cataract Surgery: The Efficacy of the Perioperative Use of a Hydroxypropyl Guar and Hyaluronic Acid Ophthalmic Solution

Eleonora Favuzza, Michela Cennamo, Lidia Vicchio, Fabrizio Giansanti, Rita Mencucci Department of Neuroscience, Psychology, Pharmacology and Child Health (NEUROFARBA), Eye Clinic, University of Florence, Florence, ItalyCorrespondence: Rita MencucciDepartment of Neuroscience, Psychology, Pharmacology...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Favuzza E, Cennamo M, Vicchio L, Giansanti F, Mencucci R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	dry eye cataract surgery artificial tears hydroxypropyl guar hyaluronic acid ocular surface Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/39d37addbaf34c46a6521010a8ab5f2e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:39d37addbaf34c46a6521010a8ab5f2e
record_format	dspace
spelling	oai:doaj.org-article:39d37addbaf34c46a6521010a8ab5f2e2021-12-02T09:40:43ZProtecting the Ocular Surface in Cataract Surgery: The Efficacy of the Perioperative Use of a Hydroxypropyl Guar and Hyaluronic Acid Ophthalmic Solution1177-5483https://doaj.org/article/39d37addbaf34c46a6521010a8ab5f2e2020-06-01T00:00:00Zhttps://www.dovepress.com/protecting-the-ocular-surface-in-cataract-surgery-the-efficacy-of-the--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Eleonora Favuzza, Michela Cennamo, Lidia Vicchio, Fabrizio Giansanti, Rita Mencucci Department of Neuroscience, Psychology, Pharmacology and Child Health (NEUROFARBA), Eye Clinic, University of Florence, Florence, ItalyCorrespondence: Rita MencucciDepartment of Neuroscience, Psychology, Pharmacology and Child Health (NEUROFARBA), Eye Clinic, University of Florence, Largo Brambilla 3, Florence 50134, ItalyTel +390557946975Email rita.mencucci@unifi.itPurpose: To evaluate the effects of a hydroxypropyl guar (HPG) and hyaluronic acid (HA) ophthalmic solution in terms of post-cataract surgery dry-eye disease (DED) prevention.Patients and Methods: In this retrospective study, the data of 419 patients not previously affected by DED, who had undergone unilateral cataract surgery in 17 Italian centers with different perioperative lubricating regimens, were retrospectively reviewed. Patients who had instilled HPG/HA solution 3 times/day in the preoperative week and for two postoperative months were included in group A; group B only instilled HPG/HA for two postoperative months; group C did not instill any perioperative artificial tears. All patients followed the same antibiotic and anti-inflammatory postoperative topical regimen. The scores of SPEED (Standard Patient Evaluation of Eye Dryness) questionnaire, tear break-up time (BUT) and corneal fluorescein staining (CFS, Oxford scale), performed at the preoperative visit and at one, four and eight postoperative weeks, were evaluated.Results: In groups A and B, the SPEED scores were significantly lower than group C in the whole postoperative period. In group A, the SPEED scores were significantly lower than group B 1 and 4 weeks after surgery (p< 0.001 and p=0.021). In group C, 25% of patients reported symptom scores corresponding to mild-moderate dry eye 4 and 8 weeks after surgery. The fluorescein tear BUT in groups A and B was significantly higher than group C in the whole postoperative period (p< 0.001). In group A, BUT was significantly higher than group B 4 weeks after surgery (p=0.016). More patients showed no corneal fluorescein staining (CFS grade=0) in groups A and B than group C at all the postoperative visits.Conclusion: The hydroxypropyl guar and hyaluronic acid ophthalmic solution was effective at reducing post-cataract surgery ocular discomfort and tear instability, particularly if also administered in the preoperative period.Keywords: dry eye, cataract surgery, artificial tears, hydroxypropyl guar, hyaluronic acid, ocular surfaceFavuzza ECennamo MVicchio LGiansanti FMencucci RDove Medical Pressarticledry eyecataract surgeryartificial tearshydroxypropyl guarhyaluronic acidocular surfaceOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1769-1775 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	dry eye cataract surgery artificial tears hydroxypropyl guar hyaluronic acid ocular surface Ophthalmology RE1-994
spellingShingle	dry eye cataract surgery artificial tears hydroxypropyl guar hyaluronic acid ocular surface Ophthalmology RE1-994 Favuzza E Cennamo M Vicchio L Giansanti F Mencucci R Protecting the Ocular Surface in Cataract Surgery: The Efficacy of the Perioperative Use of a Hydroxypropyl Guar and Hyaluronic Acid Ophthalmic Solution
description	Eleonora Favuzza, Michela Cennamo, Lidia Vicchio, Fabrizio Giansanti, Rita Mencucci Department of Neuroscience, Psychology, Pharmacology and Child Health (NEUROFARBA), Eye Clinic, University of Florence, Florence, ItalyCorrespondence: Rita MencucciDepartment of Neuroscience, Psychology, Pharmacology and Child Health (NEUROFARBA), Eye Clinic, University of Florence, Largo Brambilla 3, Florence 50134, ItalyTel +390557946975Email rita.mencucci@unifi.itPurpose: To evaluate the effects of a hydroxypropyl guar (HPG) and hyaluronic acid (HA) ophthalmic solution in terms of post-cataract surgery dry-eye disease (DED) prevention.Patients and Methods: In this retrospective study, the data of 419 patients not previously affected by DED, who had undergone unilateral cataract surgery in 17 Italian centers with different perioperative lubricating regimens, were retrospectively reviewed. Patients who had instilled HPG/HA solution 3 times/day in the preoperative week and for two postoperative months were included in group A; group B only instilled HPG/HA for two postoperative months; group C did not instill any perioperative artificial tears. All patients followed the same antibiotic and anti-inflammatory postoperative topical regimen. The scores of SPEED (Standard Patient Evaluation of Eye Dryness) questionnaire, tear break-up time (BUT) and corneal fluorescein staining (CFS, Oxford scale), performed at the preoperative visit and at one, four and eight postoperative weeks, were evaluated.Results: In groups A and B, the SPEED scores were significantly lower than group C in the whole postoperative period. In group A, the SPEED scores were significantly lower than group B 1 and 4 weeks after surgery (p< 0.001 and p=0.021). In group C, 25% of patients reported symptom scores corresponding to mild-moderate dry eye 4 and 8 weeks after surgery. The fluorescein tear BUT in groups A and B was significantly higher than group C in the whole postoperative period (p< 0.001). In group A, BUT was significantly higher than group B 4 weeks after surgery (p=0.016). More patients showed no corneal fluorescein staining (CFS grade=0) in groups A and B than group C at all the postoperative visits.Conclusion: The hydroxypropyl guar and hyaluronic acid ophthalmic solution was effective at reducing post-cataract surgery ocular discomfort and tear instability, particularly if also administered in the preoperative period.Keywords: dry eye, cataract surgery, artificial tears, hydroxypropyl guar, hyaluronic acid, ocular surface
format	article
author	Favuzza E Cennamo M Vicchio L Giansanti F Mencucci R
author_facet	Favuzza E Cennamo M Vicchio L Giansanti F Mencucci R
author_sort	Favuzza E
title	Protecting the Ocular Surface in Cataract Surgery: The Efficacy of the Perioperative Use of a Hydroxypropyl Guar and Hyaluronic Acid Ophthalmic Solution
title_short	Protecting the Ocular Surface in Cataract Surgery: The Efficacy of the Perioperative Use of a Hydroxypropyl Guar and Hyaluronic Acid Ophthalmic Solution
title_full	Protecting the Ocular Surface in Cataract Surgery: The Efficacy of the Perioperative Use of a Hydroxypropyl Guar and Hyaluronic Acid Ophthalmic Solution
title_fullStr	Protecting the Ocular Surface in Cataract Surgery: The Efficacy of the Perioperative Use of a Hydroxypropyl Guar and Hyaluronic Acid Ophthalmic Solution
title_full_unstemmed	Protecting the Ocular Surface in Cataract Surgery: The Efficacy of the Perioperative Use of a Hydroxypropyl Guar and Hyaluronic Acid Ophthalmic Solution
title_sort	protecting the ocular surface in cataract surgery: the efficacy of the perioperative use of a hydroxypropyl guar and hyaluronic acid ophthalmic solution
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/39d37addbaf34c46a6521010a8ab5f2e
work_keys_str_mv	AT favuzzae protectingtheocularsurfaceincataractsurgerytheefficacyoftheperioperativeuseofahydroxypropylguarandhyaluronicacidophthalmicsolution AT cennamom protectingtheocularsurfaceincataractsurgerytheefficacyoftheperioperativeuseofahydroxypropylguarandhyaluronicacidophthalmicsolution AT vicchiol protectingtheocularsurfaceincataractsurgerytheefficacyoftheperioperativeuseofahydroxypropylguarandhyaluronicacidophthalmicsolution AT giansantif protectingtheocularsurfaceincataractsurgerytheefficacyoftheperioperativeuseofahydroxypropylguarandhyaluronicacidophthalmicsolution AT mencuccir protectingtheocularsurfaceincataractsurgerytheefficacyoftheperioperativeuseofahydroxypropylguarandhyaluronicacidophthalmicsolution
_version_	1718398059528847360

Protecting the Ocular Surface in Cataract Surgery: The Efficacy of the Perioperative Use of a Hydroxypropyl Guar and Hyaluronic Acid Ophthalmic Solution

Ejemplares similares