Probiotics in Counteracting the Role of Neutrophils in Cancer Metastasis

Neutrophils are known for their role geared towards pathogen clearance by different mechanisms that they initiate, primarily by the release of neutrophil extracellular traps (NETs). However, their immune-surveillance capacity accompanied with plasticity in existing as interchangeable subsets, discov...

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Main Authors:	Upasana Mangrolia, Jabez W. Osborne
Format:	article
Language:	EN
Published:	MDPI AG 2021
Subjects:	neutrophils NETs cancer metastasis probiotics Medicine R
Online Access:	https://doaj.org/article/39d5b184a7c44b2297d624e14c979f91
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id	oai:doaj.org-article:39d5b184a7c44b2297d624e14c979f91
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spelling	oai:doaj.org-article:39d5b184a7c44b2297d624e14c979f912021-11-25T19:11:09ZProbiotics in Counteracting the Role of Neutrophils in Cancer Metastasis10.3390/vaccines91113062076-393Xhttps://doaj.org/article/39d5b184a7c44b2297d624e14c979f912021-11-01T00:00:00Zhttps://www.mdpi.com/2076-393X/9/11/1306https://doaj.org/toc/2076-393XNeutrophils are known for their role geared towards pathogen clearance by different mechanisms that they initiate, primarily by the release of neutrophil extracellular traps (NETs). However, their immune-surveillance capacity accompanied with plasticity in existing as interchangeable subsets, discovered recently, has revealed their property to contribute to complex cancer pathologies including tumor initiation, growth, angiogenesis and metastasis. Although there is a growing body of evidence suggesting a critical balance between the protumoral and antitumoral neutrophil phenotypes, an in-depth signaling pathway analysis would aid in determination of anticipatory, diagnostic and therapeutic targets. This review presents a comprehensive overview of the potential pathways involved in neutrophil-triggered cancer metastasis and introduces the influence of the microbial load and avenues for probiotic intervention.Upasana MangroliaJabez W. OsborneMDPI AGarticleneutrophilsNETscancermetastasisprobioticsMedicineRENVaccines, Vol 9, Iss 1306, p 1306 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neutrophils NETs cancer metastasis probiotics Medicine R
spellingShingle	neutrophils NETs cancer metastasis probiotics Medicine R Upasana Mangrolia Jabez W. Osborne Probiotics in Counteracting the Role of Neutrophils in Cancer Metastasis
description	Neutrophils are known for their role geared towards pathogen clearance by different mechanisms that they initiate, primarily by the release of neutrophil extracellular traps (NETs). However, their immune-surveillance capacity accompanied with plasticity in existing as interchangeable subsets, discovered recently, has revealed their property to contribute to complex cancer pathologies including tumor initiation, growth, angiogenesis and metastasis. Although there is a growing body of evidence suggesting a critical balance between the protumoral and antitumoral neutrophil phenotypes, an in-depth signaling pathway analysis would aid in determination of anticipatory, diagnostic and therapeutic targets. This review presents a comprehensive overview of the potential pathways involved in neutrophil-triggered cancer metastasis and introduces the influence of the microbial load and avenues for probiotic intervention.
format	article
author	Upasana Mangrolia Jabez W. Osborne
author_facet	Upasana Mangrolia Jabez W. Osborne
author_sort	Upasana Mangrolia
title	Probiotics in Counteracting the Role of Neutrophils in Cancer Metastasis
title_short	Probiotics in Counteracting the Role of Neutrophils in Cancer Metastasis
title_full	Probiotics in Counteracting the Role of Neutrophils in Cancer Metastasis
title_fullStr	Probiotics in Counteracting the Role of Neutrophils in Cancer Metastasis
title_full_unstemmed	Probiotics in Counteracting the Role of Neutrophils in Cancer Metastasis
title_sort	probiotics in counteracting the role of neutrophils in cancer metastasis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/39d5b184a7c44b2297d624e14c979f91
work_keys_str_mv	AT upasanamangrolia probioticsincounteractingtheroleofneutrophilsincancermetastasis AT jabezwosborne probioticsincounteractingtheroleofneutrophilsincancermetastasis
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Probiotics in Counteracting the Role of Neutrophils in Cancer Metastasis

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