Effects of astaxanthin supplementation in healthy and obese dogs

Tae Murai,1 Koh Kawasumi,1 Kumi Tominaga,2 Yuki Okada,1 Motoo Kobayashi,1 Toshiro Arai1 1Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo 180-8602, Japan; 2Research and Development Division, AstaReal Co. Ltd., Minat...

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Autores principales:	Murai T, Kawasumi K, Tominaga K, Okada Y, Kobayashi M, Arai T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Astaxanthin supplementation obese dogs anti-oxidative activity liver function Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/39d66119693d4006b7d70807964dafaf
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spelling	oai:doaj.org-article:39d66119693d4006b7d70807964dafaf2021-12-02T05:06:41ZEffects of astaxanthin supplementation in healthy and obese dogs2230-2034https://doaj.org/article/39d66119693d4006b7d70807964dafaf2019-02-01T00:00:00Zhttps://www.dovepress.com/effects-of-astaxanthin-supplementation-in-healthy-and-obese-dogs-peer-reviewed-article-VMRRhttps://doaj.org/toc/2230-2034Tae Murai,1 Koh Kawasumi,1 Kumi Tominaga,2 Yuki Okada,1 Motoo Kobayashi,1 Toshiro Arai1 1Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo 180-8602, Japan; 2Research and Development Division, AstaReal Co. Ltd., Minato-ku, Tokyo 105-0011, Japan Background: Since astaxanthin (ASX) has potent anti-oxidative effects with inhibitory action of lipid peroxidation and singlet oxygen quenching activity, it is widely used as a functional food for keeping good health in human. Obesity is a risk factor for various metabolic disorders. It is characterized by low-grade chronic inflammation based on oxidative stress by excessively produced ROS. From the point of preventive medicine, natural compounds have been proposed as potential therapeutic agents in the prevention of metabolic disorder in companion animals. The purpose of this study is to evaluate the effects of ASX supplementation in healthy and obese dogs. Materials and methods: Ten healthy beagle dogs and 5 clinically obese dogs were used in this study. The healthy beagle dogs were randomly divided into 2 groups as follows: control and test groups. The test group dogs received ASX supplementation mixed with the food for 6 weeks. Five clinically obese dogs received ASX supplementation for 8 weeks. Metabolites, hormones and enzymes were measured before and after ASX supplementation. Results: In the healthy dog groups, after 6 weeks, plasma triglyceride (TG) and malondialdehyde concentrations and lactate dehydrogenase (LDH) values significantly decreased in the test group. There was no significant difference in the control group. In clinically obese dogs, plasma TG concentration decreased after 8 weeks of ASX supplementation. Plasma alanine aminotransferase and LDH values clearly decreased in all 5 dogs and 4 dogs out of 5 dogs, respectively. Conclusion: ASX supplementation (0.3 mg/kg body weight/day) for 6 weeks in healthy dogs and 8 weeks in obese dogs induced the elevation of antioxidant function and of liver function by ameliorating lipid metabolism. Keywords: astaxanthin, obese dogs, lipid metabolism, anti-oxidative activity, liver functionMurai TKawasumi KTominaga KOkada YKobayashi MArai TDove Medical PressarticleAstaxanthin supplementationobese dogsanti-oxidative activityliver functionVeterinary medicineSF600-1100ENVeterinary Medicine: Research and Reports, Vol Volume 10, Pp 29-35 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Astaxanthin supplementation obese dogs anti-oxidative activity liver function Veterinary medicine SF600-1100
spellingShingle	Astaxanthin supplementation obese dogs anti-oxidative activity liver function Veterinary medicine SF600-1100 Murai T Kawasumi K Tominaga K Okada Y Kobayashi M Arai T Effects of astaxanthin supplementation in healthy and obese dogs
description	Tae Murai,1 Koh Kawasumi,1 Kumi Tominaga,2 Yuki Okada,1 Motoo Kobayashi,1 Toshiro Arai1 1Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino, Tokyo 180-8602, Japan; 2Research and Development Division, AstaReal Co. Ltd., Minato-ku, Tokyo 105-0011, Japan Background: Since astaxanthin (ASX) has potent anti-oxidative effects with inhibitory action of lipid peroxidation and singlet oxygen quenching activity, it is widely used as a functional food for keeping good health in human. Obesity is a risk factor for various metabolic disorders. It is characterized by low-grade chronic inflammation based on oxidative stress by excessively produced ROS. From the point of preventive medicine, natural compounds have been proposed as potential therapeutic agents in the prevention of metabolic disorder in companion animals. The purpose of this study is to evaluate the effects of ASX supplementation in healthy and obese dogs. Materials and methods: Ten healthy beagle dogs and 5 clinically obese dogs were used in this study. The healthy beagle dogs were randomly divided into 2 groups as follows: control and test groups. The test group dogs received ASX supplementation mixed with the food for 6 weeks. Five clinically obese dogs received ASX supplementation for 8 weeks. Metabolites, hormones and enzymes were measured before and after ASX supplementation. Results: In the healthy dog groups, after 6 weeks, plasma triglyceride (TG) and malondialdehyde concentrations and lactate dehydrogenase (LDH) values significantly decreased in the test group. There was no significant difference in the control group. In clinically obese dogs, plasma TG concentration decreased after 8 weeks of ASX supplementation. Plasma alanine aminotransferase and LDH values clearly decreased in all 5 dogs and 4 dogs out of 5 dogs, respectively. Conclusion: ASX supplementation (0.3 mg/kg body weight/day) for 6 weeks in healthy dogs and 8 weeks in obese dogs induced the elevation of antioxidant function and of liver function by ameliorating lipid metabolism. Keywords: astaxanthin, obese dogs, lipid metabolism, anti-oxidative activity, liver function
format	article
author	Murai T Kawasumi K Tominaga K Okada Y Kobayashi M Arai T
author_facet	Murai T Kawasumi K Tominaga K Okada Y Kobayashi M Arai T
author_sort	Murai T
title	Effects of astaxanthin supplementation in healthy and obese dogs
title_short	Effects of astaxanthin supplementation in healthy and obese dogs
title_full	Effects of astaxanthin supplementation in healthy and obese dogs
title_fullStr	Effects of astaxanthin supplementation in healthy and obese dogs
title_full_unstemmed	Effects of astaxanthin supplementation in healthy and obese dogs
title_sort	effects of astaxanthin supplementation in healthy and obese dogs
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/39d66119693d4006b7d70807964dafaf
work_keys_str_mv	AT murait effectsofastaxanthinsupplementationinhealthyandobesedogs AT kawasumik effectsofastaxanthinsupplementationinhealthyandobesedogs AT tominagak effectsofastaxanthinsupplementationinhealthyandobesedogs AT okaday effectsofastaxanthinsupplementationinhealthyandobesedogs AT kobayashim effectsofastaxanthinsupplementationinhealthyandobesedogs AT arait effectsofastaxanthinsupplementationinhealthyandobesedogs
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Effects of astaxanthin supplementation in healthy and obese dogs

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