Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis

Abstract Background Urinary uromodulin (uUMOD) is one of the novel biomarkers for predicting AKI. However, currently available publications showed inconsistent results. We designed this meta-analysis to evaluate the potential association between uUMOD and AKI. Methods We searched research articles w...

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Autores principales:	Ruilian You, Hua Zheng, Lubin Xu, Tiantian Ma, Gang Chen, Peng Xia, Xiaohong Fan, Peili Ji, Li Wang, Limeng Chen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Uromodulin Acute kidney injury Biomarkers Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Acceso en línea:	https://doaj.org/article/39d9c107b7594b7ab32870d7047fca84
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spelling	oai:doaj.org-article:39d9c107b7594b7ab32870d7047fca842021-11-21T12:07:35ZDecreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis10.1186/s40560-021-00584-22052-0492https://doaj.org/article/39d9c107b7594b7ab32870d7047fca842021-11-01T00:00:00Zhttps://doi.org/10.1186/s40560-021-00584-2https://doaj.org/toc/2052-0492Abstract Background Urinary uromodulin (uUMOD) is one of the novel biomarkers for predicting AKI. However, currently available publications showed inconsistent results. We designed this meta-analysis to evaluate the potential association between uUMOD and AKI. Methods We searched research articles with no language restriction in Medline, Web of Science, Cochrane Library, Embase, and 3 Chinese datasets from inception to February 2021. We used random-effects models to estimate the standardized mean difference (SMD) between patients with AKI or not, while the leave-one-out method and random-effects meta-regression to evaluate the sensitivity and the impact of potential confounders such as age and surgery. Results The meta-analysis comprising 3148 subjects from 11 studies showed that the uUMOD of the AKI group is significantly lower than the non-AKI group (SMD: − 0.71; 95% confidence interval (CI), − 1.00, − 0.42, P < 0. 001, I 2 = 78.8%). Subgroup analysis revealed the difference is also significant in a different age, surgery condition, and assay time but not acute rejection (AR) group, especially in children (SMD: − 1.21, 95% CI: − 1.80, − 0.61; P < 0.001) and patients undergoing surgery (SMD: − 1.03, 95% CI: − 1.75, − 0.30; P < 0.001). Lower uromodulin is associated with higher odds for AKI incidence (odds ratio = 2.47, 95% CI: 1.12, 5.47; P < 0.001, I 2 = 89%). Meta-reggression found that age was associated with the SMD of uUMOD. The study outcome was reliably confirmed by the sensitivity analysis. Conclusion The present study suggested a negative association between uUMOD and AKI especially in children and surgical patients.Ruilian YouHua ZhengLubin XuTiantian MaGang ChenPeng XiaXiaohong FanPeili JiLi WangLimeng ChenBMCarticleUromodulinAcute kidney injuryBiomarkersMedical emergencies. Critical care. Intensive care. First aidRC86-88.9ENJournal of Intensive Care, Vol 9, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Uromodulin Acute kidney injury Biomarkers Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
spellingShingle	Uromodulin Acute kidney injury Biomarkers Medical emergencies. Critical care. Intensive care. First aid RC86-88.9 Ruilian You Hua Zheng Lubin Xu Tiantian Ma Gang Chen Peng Xia Xiaohong Fan Peili Ji Li Wang Limeng Chen Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis
description	Abstract Background Urinary uromodulin (uUMOD) is one of the novel biomarkers for predicting AKI. However, currently available publications showed inconsistent results. We designed this meta-analysis to evaluate the potential association between uUMOD and AKI. Methods We searched research articles with no language restriction in Medline, Web of Science, Cochrane Library, Embase, and 3 Chinese datasets from inception to February 2021. We used random-effects models to estimate the standardized mean difference (SMD) between patients with AKI or not, while the leave-one-out method and random-effects meta-regression to evaluate the sensitivity and the impact of potential confounders such as age and surgery. Results The meta-analysis comprising 3148 subjects from 11 studies showed that the uUMOD of the AKI group is significantly lower than the non-AKI group (SMD: − 0.71; 95% confidence interval (CI), − 1.00, − 0.42, P < 0. 001, I 2 = 78.8%). Subgroup analysis revealed the difference is also significant in a different age, surgery condition, and assay time but not acute rejection (AR) group, especially in children (SMD: − 1.21, 95% CI: − 1.80, − 0.61; P < 0.001) and patients undergoing surgery (SMD: − 1.03, 95% CI: − 1.75, − 0.30; P < 0.001). Lower uromodulin is associated with higher odds for AKI incidence (odds ratio = 2.47, 95% CI: 1.12, 5.47; P < 0.001, I 2 = 89%). Meta-reggression found that age was associated with the SMD of uUMOD. The study outcome was reliably confirmed by the sensitivity analysis. Conclusion The present study suggested a negative association between uUMOD and AKI especially in children and surgical patients.
format	article
author	Ruilian You Hua Zheng Lubin Xu Tiantian Ma Gang Chen Peng Xia Xiaohong Fan Peili Ji Li Wang Limeng Chen
author_facet	Ruilian You Hua Zheng Lubin Xu Tiantian Ma Gang Chen Peng Xia Xiaohong Fan Peili Ji Li Wang Limeng Chen
author_sort	Ruilian You
title	Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis
title_short	Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis
title_full	Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis
title_fullStr	Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis
title_full_unstemmed	Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis
title_sort	decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/39d9c107b7594b7ab32870d7047fca84
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Decreased urinary uromodulin is potentially associated with acute kidney injury: a systematic review and meta-analysis

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