Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice

Remimazolam is a new benzodiazepine of sedative drugs with an ultra-short-acting anesthetic effect, commonly used for critically ill patients (especially septic patients) in intensive care units (ICUs). Although some anesthetics have been reported to show certain anti-inflammatory effects, the role...

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Autores principales:	Xiaolei Liu, Shaoping Lin, Yiyue Zhong, Jiaojiao Shen, Xuedi Zhang, Shuhua Luo, Li Huang, Liangqing Zhang, Shuangnan Zhou, Jing Tang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	benzodiazepine endotoxemia inflammatory remimazolam TLR4 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/39dc35741fbf49b39b3b6c74f0eb05d4
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spelling	oai:doaj.org-article:39dc35741fbf49b39b3b6c74f0eb05d42021-11-19T13:35:10ZRemimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice1663-981210.3389/fphar.2021.739603https://doaj.org/article/39dc35741fbf49b39b3b6c74f0eb05d42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.739603/fullhttps://doaj.org/toc/1663-9812Remimazolam is a new benzodiazepine of sedative drugs with an ultra-short-acting anesthetic effect, commonly used for critically ill patients (especially septic patients) in intensive care units (ICUs). Although some anesthetics have been reported to show certain anti-inflammatory effects, the role of remimazolam in inflammation is still remained unknown. Here, we studied the effects of remimazolam on macrophage in response to LPS both in vivo and in vitro. Interestingly, compared with LPS treatment group, remimazolam remarkably improved survival rate of endotoxemia mice and decreased the release of LPS-induced inflammatory mediators (such as TNF-α, IL-6, and IL-1β). We further found that remimazolam not only inhibited the activation of MAPK signal pathway at 15 min after LPS treatment but also disturbed Rab5a related TLR4 expression at cell surface in response to LPS at a later time. Such evidence suggests that remimazolam might be beneficial to septic patients who are suffering from uncontrolled inflammatory responses.Xiaolei LiuShaoping LinYiyue ZhongJiaojiao ShenXuedi ZhangShuhua LuoLi HuangLiangqing ZhangShuangnan ZhouJing TangFrontiers Media S.A.articlebenzodiazepineendotoxemiainflammatoryremimazolamTLR4Therapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	benzodiazepine endotoxemia inflammatory remimazolam TLR4 Therapeutics. Pharmacology RM1-950
spellingShingle	benzodiazepine endotoxemia inflammatory remimazolam TLR4 Therapeutics. Pharmacology RM1-950 Xiaolei Liu Shaoping Lin Yiyue Zhong Jiaojiao Shen Xuedi Zhang Shuhua Luo Li Huang Liangqing Zhang Shuangnan Zhou Jing Tang Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice
description	Remimazolam is a new benzodiazepine of sedative drugs with an ultra-short-acting anesthetic effect, commonly used for critically ill patients (especially septic patients) in intensive care units (ICUs). Although some anesthetics have been reported to show certain anti-inflammatory effects, the role of remimazolam in inflammation is still remained unknown. Here, we studied the effects of remimazolam on macrophage in response to LPS both in vivo and in vitro. Interestingly, compared with LPS treatment group, remimazolam remarkably improved survival rate of endotoxemia mice and decreased the release of LPS-induced inflammatory mediators (such as TNF-α, IL-6, and IL-1β). We further found that remimazolam not only inhibited the activation of MAPK signal pathway at 15 min after LPS treatment but also disturbed Rab5a related TLR4 expression at cell surface in response to LPS at a later time. Such evidence suggests that remimazolam might be beneficial to septic patients who are suffering from uncontrolled inflammatory responses.
format	article
author	Xiaolei Liu Shaoping Lin Yiyue Zhong Jiaojiao Shen Xuedi Zhang Shuhua Luo Li Huang Liangqing Zhang Shuangnan Zhou Jing Tang
author_facet	Xiaolei Liu Shaoping Lin Yiyue Zhong Jiaojiao Shen Xuedi Zhang Shuhua Luo Li Huang Liangqing Zhang Shuangnan Zhou Jing Tang
author_sort	Xiaolei Liu
title	Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice
title_short	Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice
title_full	Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice
title_fullStr	Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice
title_full_unstemmed	Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice
title_sort	remimazolam protects against lps-induced endotoxicity improving survival of endotoxemia mice
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/39dc35741fbf49b39b3b6c74f0eb05d4
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Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice

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