Visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency

Sean M Gratton, Byron L LamBascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL, USAAbstract: Visual loss due to optic neuropathy is a rare manifestation of thiamine deficiency. We report a case of a 39-year-old woman with a body mass index (BMI) of 29 kg/m2 who de...

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Autores principales:	Gratton SM, Lam BL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/39de7f8b15a14b3bb4fa8f8070fd0bac
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spelling	oai:doaj.org-article:39de7f8b15a14b3bb4fa8f8070fd0bac2021-12-02T02:02:39ZVisual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency1177-5483https://doaj.org/article/39de7f8b15a14b3bb4fa8f8070fd0bac2014-05-01T00:00:00Zhttp://www.dovepress.com/visual-loss-and-optic-nerve-head-swelling-in-thiamine-deficiency-witho-a16953https://doaj.org/toc/1177-5483 Sean M Gratton, Byron L LamBascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL, USAAbstract: Visual loss due to optic neuropathy is a rare manifestation of thiamine deficiency. We report a case of a 39-year-old woman with a body mass index (BMI) of 29 kg/m2 who developed visual loss and bilateral optic nerve head swelling after a short, self-limited gastrointestinal illness. She was disoriented and inattentive and had absent ankle jerk reflexes, diminished sensation in both legs below the knees, and marked truncal ataxia. Magnetic resonance imaging (MRI) showed increased T2-signal in the medial thalami and mammillary bodies. The serum thiamine level was 8 nmol/L (normal 8–30). The diagnosis of thiamine deficiency was made, and the patient’s vision and neurologic symptoms improved significantly with intramuscular thiamine treatment. Thiamine deficiency can occur in the absence of an obvious predisposing factor such as alcoholism or low body weight. The clinician must be aware of the factors that govern vitamin availability and maintain a high index of suspicion to make the diagnosis in such cases.Keywords: optic neuropathy, nutritional deficiencyGratton SMLam BLDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 1021-1024 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Gratton SM Lam BL Visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency
description	Sean M Gratton, Byron L LamBascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL, USAAbstract: Visual loss due to optic neuropathy is a rare manifestation of thiamine deficiency. We report a case of a 39-year-old woman with a body mass index (BMI) of 29 kg/m2 who developed visual loss and bilateral optic nerve head swelling after a short, self-limited gastrointestinal illness. She was disoriented and inattentive and had absent ankle jerk reflexes, diminished sensation in both legs below the knees, and marked truncal ataxia. Magnetic resonance imaging (MRI) showed increased T2-signal in the medial thalami and mammillary bodies. The serum thiamine level was 8 nmol/L (normal 8–30). The diagnosis of thiamine deficiency was made, and the patient’s vision and neurologic symptoms improved significantly with intramuscular thiamine treatment. Thiamine deficiency can occur in the absence of an obvious predisposing factor such as alcoholism or low body weight. The clinician must be aware of the factors that govern vitamin availability and maintain a high index of suspicion to make the diagnosis in such cases.Keywords: optic neuropathy, nutritional deficiency
format	article
author	Gratton SM Lam BL
author_facet	Gratton SM Lam BL
author_sort	Gratton SM
title	Visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency
title_short	Visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency
title_full	Visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency
title_fullStr	Visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency
title_full_unstemmed	Visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency
title_sort	visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/39de7f8b15a14b3bb4fa8f8070fd0bac
work_keys_str_mv	AT grattonsm visuallossandopticnerveheadswellinginthiaminedeficiencywithoutprolongeddietarydeficiency AT lambl visuallossandopticnerveheadswellinginthiaminedeficiencywithoutprolongeddietarydeficiency
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Visual loss and optic nerve head swelling in thiamine deficiency without prolonged dietary deficiency

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