Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine

The RV144 vaccine trial showed reduced risk of HIV-1 acquisition, but mechanisms underlying protection are poorly understood. Here, Fourati et al. assess the transcriptomic profile of blood collected from 223 vaccinees and 40 placebo recipients and identify IRF7 as a mediator of protection.

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Autores principales:	Slim Fourati, Susan Pereira Ribeiro, Filipa Blasco Tavares Pereira Lopes, Aarthi Talla, Francois Lefebvre, Mark Cameron, J. Kaewkungwal, P. Pitisuttithum, S. Nitayaphan, S. Rerks-Ngarm, Jerome H. Kim, Rasmi Thomas, Peter B. Gilbert, Georgia D. Tomaras, Richard A. Koup, Nelson L. Michael, M. Juliana McElrath, Raphael Gottardo, Rafick-Pierre Sékaly
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39e0d85840e44cd7872a97b96a0ffad9
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spelling	oai:doaj.org-article:39e0d85840e44cd7872a97b96a0ffad92021-12-02T16:57:21ZIntegrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine10.1038/s41467-019-08854-22041-1723https://doaj.org/article/39e0d85840e44cd7872a97b96a0ffad92019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08854-2https://doaj.org/toc/2041-1723The RV144 vaccine trial showed reduced risk of HIV-1 acquisition, but mechanisms underlying protection are poorly understood. Here, Fourati et al. assess the transcriptomic profile of blood collected from 223 vaccinees and 40 placebo recipients and identify IRF7 as a mediator of protection.Slim FouratiSusan Pereira RibeiroFilipa Blasco Tavares Pereira LopesAarthi TallaFrancois LefebvreMark CameronJ. KaewkungwalP. PitisuttithumS. NitayaphanS. Rerks-NgarmJerome H. KimRasmi ThomasPeter B. GilbertGeorgia D. TomarasRichard A. KoupNelson L. MichaelM. Juliana McElrathRaphael GottardoRafick-Pierre SékalyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Slim Fourati Susan Pereira Ribeiro Filipa Blasco Tavares Pereira Lopes Aarthi Talla Francois Lefebvre Mark Cameron J. Kaewkungwal P. Pitisuttithum S. Nitayaphan S. Rerks-Ngarm Jerome H. Kim Rasmi Thomas Peter B. Gilbert Georgia D. Tomaras Richard A. Koup Nelson L. Michael M. Juliana McElrath Raphael Gottardo Rafick-Pierre Sékaly Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine
description	The RV144 vaccine trial showed reduced risk of HIV-1 acquisition, but mechanisms underlying protection are poorly understood. Here, Fourati et al. assess the transcriptomic profile of blood collected from 223 vaccinees and 40 placebo recipients and identify IRF7 as a mediator of protection.
format	article
author	Slim Fourati Susan Pereira Ribeiro Filipa Blasco Tavares Pereira Lopes Aarthi Talla Francois Lefebvre Mark Cameron J. Kaewkungwal P. Pitisuttithum S. Nitayaphan S. Rerks-Ngarm Jerome H. Kim Rasmi Thomas Peter B. Gilbert Georgia D. Tomaras Richard A. Koup Nelson L. Michael M. Juliana McElrath Raphael Gottardo Rafick-Pierre Sékaly
author_facet	Slim Fourati Susan Pereira Ribeiro Filipa Blasco Tavares Pereira Lopes Aarthi Talla Francois Lefebvre Mark Cameron J. Kaewkungwal P. Pitisuttithum S. Nitayaphan S. Rerks-Ngarm Jerome H. Kim Rasmi Thomas Peter B. Gilbert Georgia D. Tomaras Richard A. Koup Nelson L. Michael M. Juliana McElrath Raphael Gottardo Rafick-Pierre Sékaly
author_sort	Slim Fourati
title	Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine
title_short	Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine
title_full	Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine
title_fullStr	Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine
title_full_unstemmed	Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine
title_sort	integrated systems approach defines the antiviral pathways conferring protection by the rv144 hiv vaccine
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/39e0d85840e44cd7872a97b96a0ffad9
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Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine

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