Estrogen receptor α gene polymorphisms and risk of Alzheimer’s disease: evidence from a meta-analysis
Daye Cheng,1 Bin Liang,2 Yiwen Hao,1 Wenling Zhou1 1Department of Transfusion, First Hospital of China Medical University, Shenyang, 2Department of Clinical Laboratory, High Vocational Technological College, China Medical University, Shenyang, People’s Republic of China Objective: Human...
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Dove Medical Press
2014
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oai:doaj.org-article:39e3ce06544a4501bc2649ea8851058f2021-12-02T05:09:06ZEstrogen receptor α gene polymorphisms and risk of Alzheimer’s disease: evidence from a meta-analysis1178-1998https://doaj.org/article/39e3ce06544a4501bc2649ea8851058f2014-06-01T00:00:00Zhttps://www.dovepress.com/estrogen-receptor-alphanbspgene-polymorphisms-and-risk-of-alzheimerrsq-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Daye Cheng,1 Bin Liang,2 Yiwen Hao,1 Wenling Zhou1 1Department of Transfusion, First Hospital of China Medical University, Shenyang, 2Department of Clinical Laboratory, High Vocational Technological College, China Medical University, Shenyang, People’s Republic of China Objective: Human estrogen receptor α (ESR1), a member of the nuclear receptor superfamily of ligand-activated transcription factors, is one of the key mediators of hormonal response in estrogen-sensitive tissues. Accumulating evidence has demonstrated that two of the most widely studied single-nucleotide polymorphisms in ESR1 – PvuII (T/C, rs223493) and Xbal (A/G, rs9340799) – are possibly associated with Alzheimer’s disease (AD). However, individual study results are still controversial.Materials and methods: We searched PubMed, Embase, Web of Science, Science Direct, SpringerLink, and the Chinese National Knowledge Infrastructure databases for eligible studies assessing the association of ESR1 polymorphisms and AD risk (last search performed in November 2013). Thereafter, a meta-analysis of 13,192 subjects from 18 individual studies was conducted to evaluate the association between ESR1 polymorphisms and susceptibility to AD.Results: The results indicated that a significant association was found between the ESR1 PvuII polymorphism and AD risk in Caucasian populations (CC + CT versus TT, odds ratio [OR] 1.14, 95% confidence interval [CI] 1.02–1.28, P=0.03; CT versus TT, OR 1.16, 95% CI 1.02–1.31, P=0.02), whereas no evidence of association was found in Asian populations. Nevertheless, we did not find any significant association between the ESR1 XbaI polymorphism and AD risk for any model in Caucasian and Asian populations (all P>0.05).Conclusion: Based on this meta-analysis, we conclude that the ESR1 PvuII polymorphism might be a risk factor in AD development in Caucasian populations, not in Asian populations. Further confirmation is needed from better-designed and larger studies. Keywords: Alzheimer’s disease, estrogen receptor, polymorphism, meta-analysisCheng DLiang BHao YZhou WDove Medical PressarticleAlzheimers diseaseestrogen receptorpolymorphismmeta-analysisGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 1031-1038 (2014) |
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DOAJ |
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Alzheimers disease estrogen receptor polymorphism meta-analysis Geriatrics RC952-954.6 |
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Alzheimers disease estrogen receptor polymorphism meta-analysis Geriatrics RC952-954.6 Cheng D Liang B Hao Y Zhou W Estrogen receptor α gene polymorphisms and risk of Alzheimer’s disease: evidence from a meta-analysis |
| description |
Daye Cheng,1 Bin Liang,2 Yiwen Hao,1 Wenling Zhou1 1Department of Transfusion, First Hospital of China Medical University, Shenyang, 2Department of Clinical Laboratory, High Vocational Technological College, China Medical University, Shenyang, People’s Republic of China Objective: Human estrogen receptor α (ESR1), a member of the nuclear receptor superfamily of ligand-activated transcription factors, is one of the key mediators of hormonal response in estrogen-sensitive tissues. Accumulating evidence has demonstrated that two of the most widely studied single-nucleotide polymorphisms in ESR1 – PvuII (T/C, rs223493) and Xbal (A/G, rs9340799) – are possibly associated with Alzheimer’s disease (AD). However, individual study results are still controversial.Materials and methods: We searched PubMed, Embase, Web of Science, Science Direct, SpringerLink, and the Chinese National Knowledge Infrastructure databases for eligible studies assessing the association of ESR1 polymorphisms and AD risk (last search performed in November 2013). Thereafter, a meta-analysis of 13,192 subjects from 18 individual studies was conducted to evaluate the association between ESR1 polymorphisms and susceptibility to AD.Results: The results indicated that a significant association was found between the ESR1 PvuII polymorphism and AD risk in Caucasian populations (CC + CT versus TT, odds ratio [OR] 1.14, 95% confidence interval [CI] 1.02–1.28, P=0.03; CT versus TT, OR 1.16, 95% CI 1.02–1.31, P=0.02), whereas no evidence of association was found in Asian populations. Nevertheless, we did not find any significant association between the ESR1 XbaI polymorphism and AD risk for any model in Caucasian and Asian populations (all P>0.05).Conclusion: Based on this meta-analysis, we conclude that the ESR1 PvuII polymorphism might be a risk factor in AD development in Caucasian populations, not in Asian populations. Further confirmation is needed from better-designed and larger studies. Keywords: Alzheimer’s disease, estrogen receptor, polymorphism, meta-analysis |
| format |
article |
| author |
Cheng D Liang B Hao Y Zhou W |
| author_facet |
Cheng D Liang B Hao Y Zhou W |
| author_sort |
Cheng D |
| title |
Estrogen receptor α gene polymorphisms and risk of Alzheimer’s disease: evidence from a meta-analysis |
| title_short |
Estrogen receptor α gene polymorphisms and risk of Alzheimer’s disease: evidence from a meta-analysis |
| title_full |
Estrogen receptor α gene polymorphisms and risk of Alzheimer’s disease: evidence from a meta-analysis |
| title_fullStr |
Estrogen receptor α gene polymorphisms and risk of Alzheimer’s disease: evidence from a meta-analysis |
| title_full_unstemmed |
Estrogen receptor α gene polymorphisms and risk of Alzheimer’s disease: evidence from a meta-analysis |
| title_sort |
estrogen receptor α gene polymorphisms and risk of alzheimer’s disease: evidence from a meta-analysis |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/39e3ce06544a4501bc2649ea8851058f |
| work_keys_str_mv |
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