Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3

The kinase Lkb1 is expressed in various metabolic tissues and is known to regulate cellular and systemic energy homeostasis. Here, the authors delete Lkb1 specifically in mature adipocytes of mice to show that Lkb1 regulates brown adipose tissue expansion and expression of UCP1.

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Autores principales:	Tizhong Shan, Yan Xiong, Pengpeng Zhang, Zhiguo Li, Qingyang Jiang, Pengpeng Bi, Feng Yue, Gongshe Yang, Yizhen Wang, Xiaoqi Liu, Shihuan Kuang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39e4380fe788414d88e58622e65805c8
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spelling	oai:doaj.org-article:39e4380fe788414d88e58622e65805c82021-12-02T16:56:47ZLkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC310.1038/ncomms122052041-1723https://doaj.org/article/39e4380fe788414d88e58622e65805c82016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12205https://doaj.org/toc/2041-1723The kinase Lkb1 is expressed in various metabolic tissues and is known to regulate cellular and systemic energy homeostasis. Here, the authors delete Lkb1 specifically in mature adipocytes of mice to show that Lkb1 regulates brown adipose tissue expansion and expression of UCP1.Tizhong ShanYan XiongPengpeng ZhangZhiguo LiQingyang JiangPengpeng BiFeng YueGongshe YangYizhen WangXiaoqi LiuShihuan KuangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tizhong Shan Yan Xiong Pengpeng Zhang Zhiguo Li Qingyang Jiang Pengpeng Bi Feng Yue Gongshe Yang Yizhen Wang Xiaoqi Liu Shihuan Kuang Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3
description	The kinase Lkb1 is expressed in various metabolic tissues and is known to regulate cellular and systemic energy homeostasis. Here, the authors delete Lkb1 specifically in mature adipocytes of mice to show that Lkb1 regulates brown adipose tissue expansion and expression of UCP1.
format	article
author	Tizhong Shan Yan Xiong Pengpeng Zhang Zhiguo Li Qingyang Jiang Pengpeng Bi Feng Yue Gongshe Yang Yizhen Wang Xiaoqi Liu Shihuan Kuang
author_facet	Tizhong Shan Yan Xiong Pengpeng Zhang Zhiguo Li Qingyang Jiang Pengpeng Bi Feng Yue Gongshe Yang Yizhen Wang Xiaoqi Liu Shihuan Kuang
author_sort	Tizhong Shan
title	Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3
title_short	Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3
title_full	Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3
title_fullStr	Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3
title_full_unstemmed	Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3
title_sort	lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of crtc3
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/39e4380fe788414d88e58622e65805c8
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Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3

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