Oral Grapeseed Oil and Sesame Oil in Experimental Acetic Acid-Induced Ulcerative Colitis in Rat

Background: Ulcerative colitis (UC) is a multi-factorial disease with unknown etiology and has many clinical manifestations.Objectives: The current study aimed to evaluate the effects of sesame oil (SO) and grapeseed oil (GSO) on acetic acid-induced UC inrats.Materials and Methods: Eighty...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fatemeh Hosseinzadeh, Nader Tanideh, Negar Azarpira, Azadeh Sayarifard, Masood Sepehrimanesh, Masood Salehi
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2016
Materias:	grapeseed oil sesame oil ulcerative colitis oxidative stress histopathology Medicine R
Acceso en línea:	https://doaj.org/article/39e68924b79f4fd4b8667cd97bb463e7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:39e68924b79f4fd4b8667cd97bb463e7
record_format	dspace
spelling	oai:doaj.org-article:39e68924b79f4fd4b8667cd97bb463e72021-11-15T09:45:31ZOral Grapeseed Oil and Sesame Oil in Experimental Acetic Acid-Induced Ulcerative Colitis in Rat2783-2430https://doaj.org/article/39e68924b79f4fd4b8667cd97bb463e72016-06-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_47138_9a5464ed739fe8b471f2bcbb37a7dc80.pdfhttps://doaj.org/toc/2783-2430Background: Ulcerative colitis (UC) is a multi-factorial disease with unknown etiology and has many clinical manifestations.Objectives: The current study aimed to evaluate the effects of sesame oil (SO) and grapeseed oil (GSO) on acetic acid-induced UC inrats.Materials and Methods: Eighty male rats were divided into eight groups as health control (HC1), received normal saline; HC2, receivedSO; HC3, received GSO; negative control (NC), UC and normal saline; positive control (PC), UC and mesalamine; SO, UC andSO; GSO, UC and GSO, and SO + GSO. The daily weight changes, serum levels of oxidative stress markers and lipid profile plus colonmacroscopic and microscopic histological changes were measured at the end of the seventh day.Results: Significant differences were detected betweenHC1 and PC on the 3rd (P = 0.002), 4th (0.013) and 6th days (0.014) and betweenHC1 and NC on the 4th day (0.027) in weight of rats. Use of GSO alone or in combination with SO decreased the extent of the changesboth in macroscopic and microscopic indices and also at the inflammation level. The most significant decrease in the MDA leveland the most obvious increase in the TAC belonged to the GSO group in comparison to the NC group. The lowest cholesterol (51.43± 5.62 mg/dL) and HDL levels (29.29 ± 6.24 mg/dL) were detected in response to SO consumption in comparison to NC group (P =0.030 and P = 0.257, respectively).Conclusions: GSO in combination with SO may be considered as the treatment of choice for UC based on antioxidant andhistopathological evaluations.Fatemeh HosseinzadehNader TanidehNegar AzarpiraAzadeh SayarifardMasood SepehrimaneshMasood SalehiShiraz University of Medical Sciencesarticlegrapeseed oilsesame oilulcerative colitisoxidative stresshistopathologyMedicineRENIranian Journal of Colorectal Research, Vol 4, Iss 2 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	grapeseed oil sesame oil ulcerative colitis oxidative stress histopathology Medicine R
spellingShingle	grapeseed oil sesame oil ulcerative colitis oxidative stress histopathology Medicine R Fatemeh Hosseinzadeh Nader Tanideh Negar Azarpira Azadeh Sayarifard Masood Sepehrimanesh Masood Salehi Oral Grapeseed Oil and Sesame Oil in Experimental Acetic Acid-Induced Ulcerative Colitis in Rat
description	Background: Ulcerative colitis (UC) is a multi-factorial disease with unknown etiology and has many clinical manifestations.Objectives: The current study aimed to evaluate the effects of sesame oil (SO) and grapeseed oil (GSO) on acetic acid-induced UC inrats.Materials and Methods: Eighty male rats were divided into eight groups as health control (HC1), received normal saline; HC2, receivedSO; HC3, received GSO; negative control (NC), UC and normal saline; positive control (PC), UC and mesalamine; SO, UC andSO; GSO, UC and GSO, and SO + GSO. The daily weight changes, serum levels of oxidative stress markers and lipid profile plus colonmacroscopic and microscopic histological changes were measured at the end of the seventh day.Results: Significant differences were detected betweenHC1 and PC on the 3rd (P = 0.002), 4th (0.013) and 6th days (0.014) and betweenHC1 and NC on the 4th day (0.027) in weight of rats. Use of GSO alone or in combination with SO decreased the extent of the changesboth in macroscopic and microscopic indices and also at the inflammation level. The most significant decrease in the MDA leveland the most obvious increase in the TAC belonged to the GSO group in comparison to the NC group. The lowest cholesterol (51.43± 5.62 mg/dL) and HDL levels (29.29 ± 6.24 mg/dL) were detected in response to SO consumption in comparison to NC group (P =0.030 and P = 0.257, respectively).Conclusions: GSO in combination with SO may be considered as the treatment of choice for UC based on antioxidant andhistopathological evaluations.
format	article
author	Fatemeh Hosseinzadeh Nader Tanideh Negar Azarpira Azadeh Sayarifard Masood Sepehrimanesh Masood Salehi
author_facet	Fatemeh Hosseinzadeh Nader Tanideh Negar Azarpira Azadeh Sayarifard Masood Sepehrimanesh Masood Salehi
author_sort	Fatemeh Hosseinzadeh
title	Oral Grapeseed Oil and Sesame Oil in Experimental Acetic Acid-Induced Ulcerative Colitis in Rat
title_short	Oral Grapeseed Oil and Sesame Oil in Experimental Acetic Acid-Induced Ulcerative Colitis in Rat
title_full	Oral Grapeseed Oil and Sesame Oil in Experimental Acetic Acid-Induced Ulcerative Colitis in Rat
title_fullStr	Oral Grapeseed Oil and Sesame Oil in Experimental Acetic Acid-Induced Ulcerative Colitis in Rat
title_full_unstemmed	Oral Grapeseed Oil and Sesame Oil in Experimental Acetic Acid-Induced Ulcerative Colitis in Rat
title_sort	oral grapeseed oil and sesame oil in experimental acetic acid-induced ulcerative colitis in rat
publisher	Shiraz University of Medical Sciences
publishDate	2016
url	https://doaj.org/article/39e68924b79f4fd4b8667cd97bb463e7
work_keys_str_mv	AT fatemehhosseinzadeh oralgrapeseedoilandsesameoilinexperimentalaceticacidinducedulcerativecolitisinrat AT nadertanideh oralgrapeseedoilandsesameoilinexperimentalaceticacidinducedulcerativecolitisinrat AT negarazarpira oralgrapeseedoilandsesameoilinexperimentalaceticacidinducedulcerativecolitisinrat AT azadehsayarifard oralgrapeseedoilandsesameoilinexperimentalaceticacidinducedulcerativecolitisinrat AT masoodsepehrimanesh oralgrapeseedoilandsesameoilinexperimentalaceticacidinducedulcerativecolitisinrat AT masoodsalehi oralgrapeseedoilandsesameoilinexperimentalaceticacidinducedulcerativecolitisinrat
_version_	1718428489683566592

Oral Grapeseed Oil and Sesame Oil in Experimental Acetic Acid-Induced Ulcerative Colitis in Rat

Ejemplares similares