Evidence from 3-month-old infants shows that a combination of postnatal feeding and exposures in utero shape lipid metabolism

Abstract We tested the hypothesis that both postnatal feeding and conditions in utero affect lipid metabolism in infants. Infants who experienced restrictive growth conditions in utero and others exposed to maternal hyperglycaemia were compared to a control group with respect to feeding mode. Dried...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Samuel Furse, Stuart G. Snowden, Laurentya Olga, Philippa Prentice, Ken K. Ong, Ieuan A. Hughes, Carlo L. Acerini, David B. Dunger, Albert Koulman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/39e8a98463b04a769bf8f02d6d372ea2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:39e8a98463b04a769bf8f02d6d372ea2
record_format	dspace
spelling	oai:doaj.org-article:39e8a98463b04a769bf8f02d6d372ea22021-12-02T15:09:47ZEvidence from 3-month-old infants shows that a combination of postnatal feeding and exposures in utero shape lipid metabolism10.1038/s41598-019-50693-02045-2322https://doaj.org/article/39e8a98463b04a769bf8f02d6d372ea22019-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-50693-0https://doaj.org/toc/2045-2322Abstract We tested the hypothesis that both postnatal feeding and conditions in utero affect lipid metabolism in infants. Infants who experienced restrictive growth conditions in utero and others exposed to maternal hyperglycaemia were compared to a control group with respect to feeding mode. Dried blood spots were collected from a pilot subset of infant participants of the Cambridge Baby Growth Study at 3mo. Groups: (a) a normal gestation (control, n = 40), (b) small for gestational age (SGA, n = 34) and (c) whose mothers developed hyperglycaemia (n = 59). These groups were further stratified by feeding mode; breastfed, formula-fed or received a mixed intake. Their phospholipid, glyceride and sterol fractions were profiled using direct infusion mass spectrometry. Statistical tests were used to identify molecular species that indicated differences in lipid metabolism. The abundance of several phospholipids identified by multivariate analysis, PC(34:1), PC(34:2) and PC-O(34:1), was 30–100% higher across all experimental groups. SM(39:1) was around half as abundant in in utero groups among breastfed infants only. The evidence from this pilot study shows that phospholipid metabolism is modulated by both conditions in utero and postnatal feeding in a cohort of 133 Caucasian infants, three months post partum.Samuel FurseStuart G. SnowdenLaurentya OlgaPhilippa PrenticeKen K. OngIeuan A. HughesCarlo L. AceriniDavid B. DungerAlbert KoulmanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Samuel Furse Stuart G. Snowden Laurentya Olga Philippa Prentice Ken K. Ong Ieuan A. Hughes Carlo L. Acerini David B. Dunger Albert Koulman Evidence from 3-month-old infants shows that a combination of postnatal feeding and exposures in utero shape lipid metabolism
description	Abstract We tested the hypothesis that both postnatal feeding and conditions in utero affect lipid metabolism in infants. Infants who experienced restrictive growth conditions in utero and others exposed to maternal hyperglycaemia were compared to a control group with respect to feeding mode. Dried blood spots were collected from a pilot subset of infant participants of the Cambridge Baby Growth Study at 3mo. Groups: (a) a normal gestation (control, n = 40), (b) small for gestational age (SGA, n = 34) and (c) whose mothers developed hyperglycaemia (n = 59). These groups were further stratified by feeding mode; breastfed, formula-fed or received a mixed intake. Their phospholipid, glyceride and sterol fractions were profiled using direct infusion mass spectrometry. Statistical tests were used to identify molecular species that indicated differences in lipid metabolism. The abundance of several phospholipids identified by multivariate analysis, PC(34:1), PC(34:2) and PC-O(34:1), was 30–100% higher across all experimental groups. SM(39:1) was around half as abundant in in utero groups among breastfed infants only. The evidence from this pilot study shows that phospholipid metabolism is modulated by both conditions in utero and postnatal feeding in a cohort of 133 Caucasian infants, three months post partum.
format	article
author	Samuel Furse Stuart G. Snowden Laurentya Olga Philippa Prentice Ken K. Ong Ieuan A. Hughes Carlo L. Acerini David B. Dunger Albert Koulman
author_facet	Samuel Furse Stuart G. Snowden Laurentya Olga Philippa Prentice Ken K. Ong Ieuan A. Hughes Carlo L. Acerini David B. Dunger Albert Koulman
author_sort	Samuel Furse
title	Evidence from 3-month-old infants shows that a combination of postnatal feeding and exposures in utero shape lipid metabolism
title_short	Evidence from 3-month-old infants shows that a combination of postnatal feeding and exposures in utero shape lipid metabolism
title_full	Evidence from 3-month-old infants shows that a combination of postnatal feeding and exposures in utero shape lipid metabolism
title_fullStr	Evidence from 3-month-old infants shows that a combination of postnatal feeding and exposures in utero shape lipid metabolism
title_full_unstemmed	Evidence from 3-month-old infants shows that a combination of postnatal feeding and exposures in utero shape lipid metabolism
title_sort	evidence from 3-month-old infants shows that a combination of postnatal feeding and exposures in utero shape lipid metabolism
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/39e8a98463b04a769bf8f02d6d372ea2
work_keys_str_mv	AT samuelfurse evidencefrom3montholdinfantsshowsthatacombinationofpostnatalfeedingandexposuresinuteroshapelipidmetabolism AT stuartgsnowden evidencefrom3montholdinfantsshowsthatacombinationofpostnatalfeedingandexposuresinuteroshapelipidmetabolism AT laurentyaolga evidencefrom3montholdinfantsshowsthatacombinationofpostnatalfeedingandexposuresinuteroshapelipidmetabolism AT philippaprentice evidencefrom3montholdinfantsshowsthatacombinationofpostnatalfeedingandexposuresinuteroshapelipidmetabolism AT kenkong evidencefrom3montholdinfantsshowsthatacombinationofpostnatalfeedingandexposuresinuteroshapelipidmetabolism AT ieuanahughes evidencefrom3montholdinfantsshowsthatacombinationofpostnatalfeedingandexposuresinuteroshapelipidmetabolism AT carlolacerini evidencefrom3montholdinfantsshowsthatacombinationofpostnatalfeedingandexposuresinuteroshapelipidmetabolism AT davidbdunger evidencefrom3montholdinfantsshowsthatacombinationofpostnatalfeedingandexposuresinuteroshapelipidmetabolism AT albertkoulman evidencefrom3montholdinfantsshowsthatacombinationofpostnatalfeedingandexposuresinuteroshapelipidmetabolism
_version_	1718387745751040000

Evidence from 3-month-old infants shows that a combination of postnatal feeding and exposures in utero shape lipid metabolism

Ejemplares similares