The association between NAFLD and risk of chronic kidney disease: a cross-sectional study

Objective: The aim of this study was to evaluate the association between nonalcoholic fatty liver disease (NAFLD) and NAFLD with different comorbidities and risk of chronic kidney disease (CKD) and abnormal albuminuria. Materials and Methods: A total of 3872 Chinese individuals excluding those with...

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Autores principales:	Ying Cao, You Deng, Jingjing Wang, Hong Zhao, Jingyu Zhang, Wen Xie
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/39e9065d1081459eb92192b66e7838fa
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spelling	oai:doaj.org-article:39e9065d1081459eb92192b66e7838fa2021-11-10T23:03:29ZThe association between NAFLD and risk of chronic kidney disease: a cross-sectional study2040-623110.1177/20406223211048649https://doaj.org/article/39e9065d1081459eb92192b66e7838fa2021-11-01T00:00:00Zhttps://doi.org/10.1177/20406223211048649https://doaj.org/toc/2040-6231Objective: The aim of this study was to evaluate the association between nonalcoholic fatty liver disease (NAFLD) and NAFLD with different comorbidities and risk of chronic kidney disease (CKD) and abnormal albuminuria. Materials and Methods: A total of 3872 Chinese individuals excluding those with hepatitis B or C infection and absence of alcohol abuse were included in the study. NAFLD was diagnosed by abdominal ultrasonography. The liver fibrosis was assessed by NAFLD fibrosis score (NFS) and fibrosis-4 index (FIB-4). CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m 2 and/or abnormal albuminuria (urinary albumin-to-creatinine ratio ⩾ 3 mg/mmol). The logistic regression analysis was performed to examine the association between NAFLD and NAFLD with different comorbidities and risk of CKD. Results: The prevalence of CKD and abnormal albuminuria was higher in individuals with NAFLD than in those without NAFLD (15.8% vs 11.9%, p < 0.001; 14.8% vs 11.0%, p < 0.001). Logistic regression analysis demonstrated that NAFLD was risk factor of CKD. Notably, after adjustment for sex, age, and DM, NAFLD was associated with 1.31-fold higher risk of prevalent CKD ⩾ 1 ( p < 0.05). NAFLD individuals with elder age, DM, obesity, hypertension, MetS, and advanced liver fibrosis had higher risks of both prevalent CKD and abnormal albuminuria than those without comorbidities. Conclusions: NAFLD and NAFLD with traditional comorbidities are strongly associated with risk of prevalence of CKD and abnormal albuminuria. Patients with NAFLD especially those with coexisting comorbidities were recommended to carefully access the development of CKD.Ying CaoYou DengJingjing WangHong ZhaoJingyu ZhangWen XieSAGE PublishingarticleTherapeutics. PharmacologyRM1-950ENTherapeutic Advances in Chronic Disease, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950
spellingShingle	Therapeutics. Pharmacology RM1-950 Ying Cao You Deng Jingjing Wang Hong Zhao Jingyu Zhang Wen Xie The association between NAFLD and risk of chronic kidney disease: a cross-sectional study
description	Objective: The aim of this study was to evaluate the association between nonalcoholic fatty liver disease (NAFLD) and NAFLD with different comorbidities and risk of chronic kidney disease (CKD) and abnormal albuminuria. Materials and Methods: A total of 3872 Chinese individuals excluding those with hepatitis B or C infection and absence of alcohol abuse were included in the study. NAFLD was diagnosed by abdominal ultrasonography. The liver fibrosis was assessed by NAFLD fibrosis score (NFS) and fibrosis-4 index (FIB-4). CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m 2 and/or abnormal albuminuria (urinary albumin-to-creatinine ratio ⩾ 3 mg/mmol). The logistic regression analysis was performed to examine the association between NAFLD and NAFLD with different comorbidities and risk of CKD. Results: The prevalence of CKD and abnormal albuminuria was higher in individuals with NAFLD than in those without NAFLD (15.8% vs 11.9%, p < 0.001; 14.8% vs 11.0%, p < 0.001). Logistic regression analysis demonstrated that NAFLD was risk factor of CKD. Notably, after adjustment for sex, age, and DM, NAFLD was associated with 1.31-fold higher risk of prevalent CKD ⩾ 1 ( p < 0.05). NAFLD individuals with elder age, DM, obesity, hypertension, MetS, and advanced liver fibrosis had higher risks of both prevalent CKD and abnormal albuminuria than those without comorbidities. Conclusions: NAFLD and NAFLD with traditional comorbidities are strongly associated with risk of prevalence of CKD and abnormal albuminuria. Patients with NAFLD especially those with coexisting comorbidities were recommended to carefully access the development of CKD.
format	article
author	Ying Cao You Deng Jingjing Wang Hong Zhao Jingyu Zhang Wen Xie
author_facet	Ying Cao You Deng Jingjing Wang Hong Zhao Jingyu Zhang Wen Xie
author_sort	Ying Cao
title	The association between NAFLD and risk of chronic kidney disease: a cross-sectional study
title_short	The association between NAFLD and risk of chronic kidney disease: a cross-sectional study
title_full	The association between NAFLD and risk of chronic kidney disease: a cross-sectional study
title_fullStr	The association between NAFLD and risk of chronic kidney disease: a cross-sectional study
title_full_unstemmed	The association between NAFLD and risk of chronic kidney disease: a cross-sectional study
title_sort	association between nafld and risk of chronic kidney disease: a cross-sectional study
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/39e9065d1081459eb92192b66e7838fa
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The association between NAFLD and risk of chronic kidney disease: a cross-sectional study

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