Regulatory T cell function in autoimmune disease

Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoi...

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Autores principales:	Anandi Rajendeeran, Klaus Tenbrock
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Foxp3 IL-2 Regulatory T cells Juvenile idiopathic arthritis SLE Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/39eb10fe5bf04b349aa0058ae4e64bb4
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spelling	oai:doaj.org-article:39eb10fe5bf04b349aa0058ae4e64bb42021-11-06T04:35:39ZRegulatory T cell function in autoimmune disease2589-909010.1016/j.jtauto.2021.100130https://doaj.org/article/39eb10fe5bf04b349aa0058ae4e64bb42021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589909021000502https://doaj.org/toc/2589-9090Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoid and juvenile idiopathic arthritis as well as systemic lupus erythematosus with an overview over current and future therapeutic options to boost Treg function.Anandi RajendeeranKlaus TenbrockElsevierarticleFoxp3IL-2Regulatory T cellsJuvenile idiopathic arthritisSLEImmunologic diseases. AllergyRC581-607ENJournal of Translational Autoimmunity, Vol 4, Iss , Pp 100130- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Foxp3 IL-2 Regulatory T cells Juvenile idiopathic arthritis SLE Immunologic diseases. Allergy RC581-607
spellingShingle	Foxp3 IL-2 Regulatory T cells Juvenile idiopathic arthritis SLE Immunologic diseases. Allergy RC581-607 Anandi Rajendeeran Klaus Tenbrock Regulatory T cell function in autoimmune disease
description	Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance. This review focusses on the function and pathophysiology of regulatory T cells in the context of autoimmune diseases including rheumatoid and juvenile idiopathic arthritis as well as systemic lupus erythematosus with an overview over current and future therapeutic options to boost Treg function.
format	article
author	Anandi Rajendeeran Klaus Tenbrock
author_facet	Anandi Rajendeeran Klaus Tenbrock
author_sort	Anandi Rajendeeran
title	Regulatory T cell function in autoimmune disease
title_short	Regulatory T cell function in autoimmune disease
title_full	Regulatory T cell function in autoimmune disease
title_fullStr	Regulatory T cell function in autoimmune disease
title_full_unstemmed	Regulatory T cell function in autoimmune disease
title_sort	regulatory t cell function in autoimmune disease
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/39eb10fe5bf04b349aa0058ae4e64bb4
work_keys_str_mv	AT anandirajendeeran regulatorytcellfunctioninautoimmunedisease AT klaustenbrock regulatorytcellfunctioninautoimmunedisease
_version_	1718443847064748032

Regulatory T cell function in autoimmune disease

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