Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

Cyclophilins play a key role in the life cycle of many viruses and represent important drug targets for broad-spectrum antiviral therapies. Here, the authors use fragment-based drug discovery to develop non-peptidic inhibitors of human cyclophilins with high activity against replication of a number...

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Autores principales:	Abdelhakim Ahmed-Belkacem, Lionel Colliandre, Nazim Ahnou, Quentin Nevers, Muriel Gelin, Yannick Bessin, Rozenn Brillet, Olivier Cala, Dominique Douguet, William Bourguet, Isabelle Krimm, Jean-Michel Pawlotsky, Jean- François Guichou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39ec7c8e931548f1a43d8bd4de43a06f
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spelling	oai:doaj.org-article:39ec7c8e931548f1a43d8bd4de43a06f2021-12-02T16:56:45ZFragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities10.1038/ncomms127772041-1723https://doaj.org/article/39ec7c8e931548f1a43d8bd4de43a06f2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12777https://doaj.org/toc/2041-1723Cyclophilins play a key role in the life cycle of many viruses and represent important drug targets for broad-spectrum antiviral therapies. Here, the authors use fragment-based drug discovery to develop non-peptidic inhibitors of human cyclophilins with high activity against replication of a number of viral families.Abdelhakim Ahmed-BelkacemLionel ColliandreNazim AhnouQuentin NeversMuriel GelinYannick BessinRozenn BrilletOlivier CalaDominique DouguetWilliam BourguetIsabelle KrimmJean-Michel PawlotskyJean- François GuichouNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Abdelhakim Ahmed-Belkacem Lionel Colliandre Nazim Ahnou Quentin Nevers Muriel Gelin Yannick Bessin Rozenn Brillet Olivier Cala Dominique Douguet William Bourguet Isabelle Krimm Jean-Michel Pawlotsky Jean- François Guichou Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities
description	Cyclophilins play a key role in the life cycle of many viruses and represent important drug targets for broad-spectrum antiviral therapies. Here, the authors use fragment-based drug discovery to develop non-peptidic inhibitors of human cyclophilins with high activity against replication of a number of viral families.
format	article
author	Abdelhakim Ahmed-Belkacem Lionel Colliandre Nazim Ahnou Quentin Nevers Muriel Gelin Yannick Bessin Rozenn Brillet Olivier Cala Dominique Douguet William Bourguet Isabelle Krimm Jean-Michel Pawlotsky Jean- François Guichou
author_facet	Abdelhakim Ahmed-Belkacem Lionel Colliandre Nazim Ahnou Quentin Nevers Muriel Gelin Yannick Bessin Rozenn Brillet Olivier Cala Dominique Douguet William Bourguet Isabelle Krimm Jean-Michel Pawlotsky Jean- François Guichou
author_sort	Abdelhakim Ahmed-Belkacem
title	Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities
title_short	Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities
title_full	Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities
title_fullStr	Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities
title_full_unstemmed	Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities
title_sort	fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/39ec7c8e931548f1a43d8bd4de43a06f
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Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

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