The CD14 (−159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes

The CD14 (−159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes

Abstract LPS-ligation to CD14/TLR-4 on monocytes/macrophages triggers the production of IL-12-family cytokines. IL12/18 promote TH1-differentiation, counteracting the TH2-driven asthma. Therefore, CD14 modulation could alter the TH2-differentiation and should be taken into account when studying asth...

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Autores principales: J. J. Nieto-Fontarigo, F. J. Salgado, M. E. San-José, M. J. Cruz, A. Casas-Fernández, M. J. Gómez-Conde, L. Valdés-Cuadrado, M. Á. García-González, P. Arias, M. Nogueira, F. J. González-Barcala
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/39f36710d7c84494bb6210b4d752f648
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