Distinct Prognostic Role of Serum Uric Acid Levels for Predicting All-Cause Mortality Among Chinese Adults Aged 45~75 Years With and Without Diabetes
IntroductionThe current study sought to explore the effect of baseline serum uric acid (SUA) on the risk of all-cause mortality among Chinese adults aged 45~75 years and to determine its interaction relationship with diabetes.MethodsThe study was designed as a community-based cohort of 4467 adults a...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/39f5235babca47d9a01abb4f02a4151d |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:39f5235babca47d9a01abb4f02a4151d |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:39f5235babca47d9a01abb4f02a4151d2021-11-16T07:43:12ZDistinct Prognostic Role of Serum Uric Acid Levels for Predicting All-Cause Mortality Among Chinese Adults Aged 45~75 Years With and Without Diabetes1664-239210.3389/fendo.2021.782230https://doaj.org/article/39f5235babca47d9a01abb4f02a4151d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.782230/fullhttps://doaj.org/toc/1664-2392IntroductionThe current study sought to explore the effect of baseline serum uric acid (SUA) on the risk of all-cause mortality among Chinese adults aged 45~75 years and to determine its interaction relationship with diabetes.MethodsThe study was designed as a community-based cohort of 4467 adults aged between 45~75 years included in a 6-years follow-up period from 2009 to 2015 years by the China Health and Nutrition Survey (CHNS). Baseline SUA levels were grouped into quartiles and its association on all-cause mortality was explored using multivariate Cox proportional hazards models. Stratified analyses were performed to explore the associations of SUA quartiles with all-cause mortality among diabetic and non-diabetic individuals.ResultsA total of 141 deaths (5.3 per 1000 person-years) were recorded During a follow-up of 26431 person-years. Out of the 141 deaths, 28 deaths (10.1 per 1000 person-years) were reported in the diabetic groups and 113 deaths (4.8 per 1000 person-years) were recorded in the non-diabetic group. An increased risk of all-cause mortality was observed for participants in the first and fourth quartiles compared with the second SUA quartile, (Q1 SUA: aHR=2.1, 95% CI 1.1~4.1; Q4 SUA: aHR=2.1, 95% CI 1.1~4.0). Stratification of participants by diabetes status showed a U-shaped association for non-diabetic individuals. Whereas, declined eGFR, rather than SUA, was an independent risk factor for all-cause mortality in diabetic individuals (aHR=0.7, 95% CI 0.6~1.0).ConclusionOur study proved that the prognostic role of SUA for predicting all-cause death might be regulated by diabetes. Both low and high SUA levels were associated with increased mortality, supporting a U-shaped association only in non-diabetic individuals. Whereas, renal dysfunction rather than SUA was an independent risk factor for all-cause mortality. Further studies should be conducted to determine the SUA levels at which intervention should be conducted and explore target follow-up strategies to prevent progression leading to poor prognosis.Bowen ZhuBowen ZhuBowen ZhuJian ZhangJian ZhangJian ZhangNana SongNana SongNana SongYiqin ShiYiqin ShiYiqin ShiYi FangYi FangYi FangXiaoqiang DingXiaoqiang DingXiaoqiang DingYang LiYang LiYang LiFrontiers Media S.A.articleserum uric aciddiabetesall-cause mortalityepidemiologyChina Health and Nutrition SurveyDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
serum uric acid diabetes all-cause mortality epidemiology China Health and Nutrition Survey Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
| spellingShingle |
serum uric acid diabetes all-cause mortality epidemiology China Health and Nutrition Survey Diseases of the endocrine glands. Clinical endocrinology RC648-665 Bowen Zhu Bowen Zhu Bowen Zhu Jian Zhang Jian Zhang Jian Zhang Nana Song Nana Song Nana Song Yiqin Shi Yiqin Shi Yiqin Shi Yi Fang Yi Fang Yi Fang Xiaoqiang Ding Xiaoqiang Ding Xiaoqiang Ding Yang Li Yang Li Yang Li Distinct Prognostic Role of Serum Uric Acid Levels for Predicting All-Cause Mortality Among Chinese Adults Aged 45~75 Years With and Without Diabetes |
| description |
IntroductionThe current study sought to explore the effect of baseline serum uric acid (SUA) on the risk of all-cause mortality among Chinese adults aged 45~75 years and to determine its interaction relationship with diabetes.MethodsThe study was designed as a community-based cohort of 4467 adults aged between 45~75 years included in a 6-years follow-up period from 2009 to 2015 years by the China Health and Nutrition Survey (CHNS). Baseline SUA levels were grouped into quartiles and its association on all-cause mortality was explored using multivariate Cox proportional hazards models. Stratified analyses were performed to explore the associations of SUA quartiles with all-cause mortality among diabetic and non-diabetic individuals.ResultsA total of 141 deaths (5.3 per 1000 person-years) were recorded During a follow-up of 26431 person-years. Out of the 141 deaths, 28 deaths (10.1 per 1000 person-years) were reported in the diabetic groups and 113 deaths (4.8 per 1000 person-years) were recorded in the non-diabetic group. An increased risk of all-cause mortality was observed for participants in the first and fourth quartiles compared with the second SUA quartile, (Q1 SUA: aHR=2.1, 95% CI 1.1~4.1; Q4 SUA: aHR=2.1, 95% CI 1.1~4.0). Stratification of participants by diabetes status showed a U-shaped association for non-diabetic individuals. Whereas, declined eGFR, rather than SUA, was an independent risk factor for all-cause mortality in diabetic individuals (aHR=0.7, 95% CI 0.6~1.0).ConclusionOur study proved that the prognostic role of SUA for predicting all-cause death might be regulated by diabetes. Both low and high SUA levels were associated with increased mortality, supporting a U-shaped association only in non-diabetic individuals. Whereas, renal dysfunction rather than SUA was an independent risk factor for all-cause mortality. Further studies should be conducted to determine the SUA levels at which intervention should be conducted and explore target follow-up strategies to prevent progression leading to poor prognosis. |
| format |
article |
| author |
Bowen Zhu Bowen Zhu Bowen Zhu Jian Zhang Jian Zhang Jian Zhang Nana Song Nana Song Nana Song Yiqin Shi Yiqin Shi Yiqin Shi Yi Fang Yi Fang Yi Fang Xiaoqiang Ding Xiaoqiang Ding Xiaoqiang Ding Yang Li Yang Li Yang Li |
| author_facet |
Bowen Zhu Bowen Zhu Bowen Zhu Jian Zhang Jian Zhang Jian Zhang Nana Song Nana Song Nana Song Yiqin Shi Yiqin Shi Yiqin Shi Yi Fang Yi Fang Yi Fang Xiaoqiang Ding Xiaoqiang Ding Xiaoqiang Ding Yang Li Yang Li Yang Li |
| author_sort |
Bowen Zhu |
| title |
Distinct Prognostic Role of Serum Uric Acid Levels for Predicting All-Cause Mortality Among Chinese Adults Aged 45~75 Years With and Without Diabetes |
| title_short |
Distinct Prognostic Role of Serum Uric Acid Levels for Predicting All-Cause Mortality Among Chinese Adults Aged 45~75 Years With and Without Diabetes |
| title_full |
Distinct Prognostic Role of Serum Uric Acid Levels for Predicting All-Cause Mortality Among Chinese Adults Aged 45~75 Years With and Without Diabetes |
| title_fullStr |
Distinct Prognostic Role of Serum Uric Acid Levels for Predicting All-Cause Mortality Among Chinese Adults Aged 45~75 Years With and Without Diabetes |
| title_full_unstemmed |
Distinct Prognostic Role of Serum Uric Acid Levels for Predicting All-Cause Mortality Among Chinese Adults Aged 45~75 Years With and Without Diabetes |
| title_sort |
distinct prognostic role of serum uric acid levels for predicting all-cause mortality among chinese adults aged 45~75 years with and without diabetes |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/39f5235babca47d9a01abb4f02a4151d |
| work_keys_str_mv |
AT bowenzhu distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT bowenzhu distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT bowenzhu distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT jianzhang distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT jianzhang distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT jianzhang distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT nanasong distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT nanasong distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT nanasong distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT yiqinshi distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT yiqinshi distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT yiqinshi distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT yifang distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT yifang distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT yifang distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT xiaoqiangding distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT xiaoqiangding distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT xiaoqiangding distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT yangli distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT yangli distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes AT yangli distinctprognosticroleofserumuricacidlevelsforpredictingallcausemortalityamongchineseadultsaged4575yearswithandwithoutdiabetes |
| _version_ |
1718426597656100864 |