Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle

Periodontitis is a chronic inflammatory immune disease associated with a dysbiotic state, influenced by keystone bacterial species responsible for disrupting the periodontal tissue homeostasis. Furthermore, the severity of periodontitis is determined by the interaction between the immune cell respon...

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Autores principales:	María José Bendek, Gisela Canedo-Marroquín, Ornella Realini, Ignacio N. Retamal, Marcela Hernández, Anilei Hoare, Dolores Busso, Lara J. Monteiro, Sebastián E. Illanes, Alejandra Chaparro
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	periodontitis gestational diabetes mellitus systemic inflammation extracellular vesicles Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/39f9b247c8494b1d8b1505f6a6e360a3
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spelling	oai:doaj.org-article:39f9b247c8494b1d8b1505f6a6e360a32021-11-11T17:15:56ZPeriodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle10.3390/ijms2221118311422-00671661-6596https://doaj.org/article/39f9b247c8494b1d8b1505f6a6e360a32021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11831https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Periodontitis is a chronic inflammatory immune disease associated with a dysbiotic state, influenced by keystone bacterial species responsible for disrupting the periodontal tissue homeostasis. Furthermore, the severity of periodontitis is determined by the interaction between the immune cell response in front of periodontitis-associated species, which leads to the destruction of supporting periodontal tissues and tooth loss in a susceptible host. The persistent bacterial challenge induces modifications in the permeability and ulceration of the sulcular epithelium, which facilitates the systemic translocation of periodontitis-associated bacteria into distant tissues and organs. This stimulates the secretion of pro-inflammatory molecules and a chronic activation of immune cells, contributing to a systemic pro-inflammatory status that has been linked with a higher risk of several systemic diseases, such as type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM). Although periodontitis and GDM share the common feature of systemic inflammation, the molecular mechanistic link of this association has not been completely clarified. This review aims to examine the potential biological mechanisms involved in the association between periodontitis and GDM, highlighting the contribution of both diseases to systemic inflammation and the role of new molecular participants, such as extracellular vesicles and non-coding RNAs, which could act as novel molecular intercellular linkers between periodontal and placental tissues.María José BendekGisela Canedo-MarroquínOrnella RealiniIgnacio N. RetamalMarcela HernándezAnilei HoareDolores BussoLara J. MonteiroSebastián E. IllanesAlejandra ChaparroMDPI AGarticleperiodontitisgestational diabetes mellitussystemic inflammationextracellular vesiclesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11831, p 11831 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	periodontitis gestational diabetes mellitus systemic inflammation extracellular vesicles Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	periodontitis gestational diabetes mellitus systemic inflammation extracellular vesicles Biology (General) QH301-705.5 Chemistry QD1-999 María José Bendek Gisela Canedo-Marroquín Ornella Realini Ignacio N. Retamal Marcela Hernández Anilei Hoare Dolores Busso Lara J. Monteiro Sebastián E. Illanes Alejandra Chaparro Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle
description	Periodontitis is a chronic inflammatory immune disease associated with a dysbiotic state, influenced by keystone bacterial species responsible for disrupting the periodontal tissue homeostasis. Furthermore, the severity of periodontitis is determined by the interaction between the immune cell response in front of periodontitis-associated species, which leads to the destruction of supporting periodontal tissues and tooth loss in a susceptible host. The persistent bacterial challenge induces modifications in the permeability and ulceration of the sulcular epithelium, which facilitates the systemic translocation of periodontitis-associated bacteria into distant tissues and organs. This stimulates the secretion of pro-inflammatory molecules and a chronic activation of immune cells, contributing to a systemic pro-inflammatory status that has been linked with a higher risk of several systemic diseases, such as type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus (GDM). Although periodontitis and GDM share the common feature of systemic inflammation, the molecular mechanistic link of this association has not been completely clarified. This review aims to examine the potential biological mechanisms involved in the association between periodontitis and GDM, highlighting the contribution of both diseases to systemic inflammation and the role of new molecular participants, such as extracellular vesicles and non-coding RNAs, which could act as novel molecular intercellular linkers between periodontal and placental tissues.
format	article
author	María José Bendek Gisela Canedo-Marroquín Ornella Realini Ignacio N. Retamal Marcela Hernández Anilei Hoare Dolores Busso Lara J. Monteiro Sebastián E. Illanes Alejandra Chaparro
author_facet	María José Bendek Gisela Canedo-Marroquín Ornella Realini Ignacio N. Retamal Marcela Hernández Anilei Hoare Dolores Busso Lara J. Monteiro Sebastián E. Illanes Alejandra Chaparro
author_sort	María José Bendek
title	Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle
title_short	Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle
title_full	Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle
title_fullStr	Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle
title_full_unstemmed	Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle
title_sort	periodontitis and gestational diabetes mellitus: a potential inflammatory vicious cycle
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/39f9b247c8494b1d8b1505f6a6e360a3
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_version_	1718432111433613312

Periodontitis and Gestational Diabetes Mellitus: A Potential Inflammatory Vicious Cycle

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