Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets

Diabetes is associated with an increased thrombotic response, but the mechanism is unknown. Here the authors demonstrate that compressive force activates integrin αIIbβ3 on discoid diabetic platelets and that platelet aggregates can be eliminated by PI 3-kinase inhibition, but not by anti-thrombotic...

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Autores principales:	Lining Ju, James D. McFadyen, Saheb Al-Daher, Imala Alwis, Yunfeng Chen, Lotte L. Tønnesen, Sophie Maiocchi, Brianna Coulter, Anna C. Calkin, Eric I. Felner, Neale Cohen, Yuping Yuan, Simone M. Schoenwaelder, Mark E. Cooper, Cheng Zhu, Shaun P. Jackson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39fb3cca5ca9489ba78bd4ef5db73aba
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spelling	oai:doaj.org-article:39fb3cca5ca9489ba78bd4ef5db73aba2021-12-02T14:40:05ZCompression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets10.1038/s41467-018-03430-62041-1723https://doaj.org/article/39fb3cca5ca9489ba78bd4ef5db73aba2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03430-6https://doaj.org/toc/2041-1723Diabetes is associated with an increased thrombotic response, but the mechanism is unknown. Here the authors demonstrate that compressive force activates integrin αIIbβ3 on discoid diabetic platelets and that platelet aggregates can be eliminated by PI 3-kinase inhibition, but not by anti-thrombotics aspirin or clopidogrel.Lining JuJames D. McFadyenSaheb Al-DaherImala AlwisYunfeng ChenLotte L. TønnesenSophie MaiocchiBrianna CoulterAnna C. CalkinEric I. FelnerNeale CohenYuping YuanSimone M. SchoenwaelderMark E. CooperCheng ZhuShaun P. JacksonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lining Ju James D. McFadyen Saheb Al-Daher Imala Alwis Yunfeng Chen Lotte L. Tønnesen Sophie Maiocchi Brianna Coulter Anna C. Calkin Eric I. Felner Neale Cohen Yuping Yuan Simone M. Schoenwaelder Mark E. Cooper Cheng Zhu Shaun P. Jackson Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets
description	Diabetes is associated with an increased thrombotic response, but the mechanism is unknown. Here the authors demonstrate that compressive force activates integrin αIIbβ3 on discoid diabetic platelets and that platelet aggregates can be eliminated by PI 3-kinase inhibition, but not by anti-thrombotics aspirin or clopidogrel.
format	article
author	Lining Ju James D. McFadyen Saheb Al-Daher Imala Alwis Yunfeng Chen Lotte L. Tønnesen Sophie Maiocchi Brianna Coulter Anna C. Calkin Eric I. Felner Neale Cohen Yuping Yuan Simone M. Schoenwaelder Mark E. Cooper Cheng Zhu Shaun P. Jackson
author_facet	Lining Ju James D. McFadyen Saheb Al-Daher Imala Alwis Yunfeng Chen Lotte L. Tønnesen Sophie Maiocchi Brianna Coulter Anna C. Calkin Eric I. Felner Neale Cohen Yuping Yuan Simone M. Schoenwaelder Mark E. Cooper Cheng Zhu Shaun P. Jackson
author_sort	Lining Ju
title	Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets
title_short	Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets
title_full	Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets
title_fullStr	Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets
title_full_unstemmed	Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets
title_sort	compression force sensing regulates integrin αiibβ3 adhesive function on diabetic platelets
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/39fb3cca5ca9489ba78bd4ef5db73aba
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Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets

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