A Bioimpedance-Based Device to Assess the Volume Conduction Properties of the Tongue in Neurological Disorders Affecting Bulbar function

<italic>Goal:</italic> Current instruments for bulbar assessment exhibit technical limitations that hinder the execution of clinical studies. The volume conduction properties (VCP) of the tongue reflect ionic content and myofiber integrity and they can serve as a new biomarker for evalua...

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Autores principales:	Xuesong Luo, Hilda Victoria Gutierrez Pulido, Seward Rutkove, Benjamin Sanchez
Formato:	article
Lenguaje:	EN
Publicado:	IEEE 2021
Materias:	Tongue volume conduction properties anisotropy electrodes biomarker Computer applications to medicine. Medical informatics R858-859.7 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/39fefe66a5e74c9eadce92f533ff654b
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spelling	oai:doaj.org-article:39fefe66a5e74c9eadce92f533ff654b2021-11-24T00:04:02ZA Bioimpedance-Based Device to Assess the Volume Conduction Properties of the Tongue in Neurological Disorders Affecting Bulbar function2644-127610.1109/OJEMB.2021.3117871https://doaj.org/article/39fefe66a5e74c9eadce92f533ff654b2021-01-01T00:00:00Zhttps://ieeexplore.ieee.org/document/9560103/https://doaj.org/toc/2644-1276<italic>Goal:</italic> Current instruments for bulbar assessment exhibit technical limitations that hinder the execution of clinical studies. The volume conduction properties (VCP) of the tongue reflect ionic content and myofiber integrity and they can serve as a new biomarker for evaluating neurological disorders with bulbar dysfunction. <italic>Methods:</italic> We designed a standalone bioimpedance measurement system that enables accurate, multi-frequency measurement of tongue anisotropic VCP including conductivity and relative permittivity. The system includes a tongue depressor with 16 non-invasive surface sensors for electrical contact with the tongue at directions 0<inline-formula><tex-math notation="LaTeX">$^{\circ }$</tex-math></inline-formula>, 45<inline-formula><tex-math notation="LaTeX">$^{\circ }$</tex-math></inline-formula>, 90<inline-formula><tex-math notation="LaTeX">$^{\circ }$</tex-math></inline-formula> and 150<inline-formula><tex-math notation="LaTeX">$^{\circ }$</tex-math></inline-formula>. The depressor is interfaced with the tongue electronic system with Bluetooth connectivity, and a smartphone application. De-identified patient data is sent by email. <italic>Results:</italic> We first determined the accuracy of the hardware performing phantom measurements mimicking a broad range of tongue values and determined the error to be <inline-formula><tex-math notation="LaTeX">$< $</tex-math></inline-formula>1%. We then validated our new technology measuring a cohort of 7 healthy human subjects under Institutional Review Board approval. <italic>Conclusions:</italic> None of the subjects who participated suffered discomfort or gag reflexes. The novel technique presented for intra-oral assessment of tongue VCP provides standard, objective and quantitative data potentially sensitive to alterations in tongue internal structure and composition.Xuesong LuoHilda Victoria Gutierrez PulidoSeward RutkoveBenjamin SanchezIEEEarticleTonguevolume conduction propertiesanisotropyelectrodesbiomarkerComputer applications to medicine. Medical informaticsR858-859.7Medical technologyR855-855.5ENIEEE Open Journal of Engineering in Medicine and Biology, Vol 2, Pp 278-285 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Tongue volume conduction properties anisotropy electrodes biomarker Computer applications to medicine. Medical informatics R858-859.7 Medical technology R855-855.5
spellingShingle	Tongue volume conduction properties anisotropy electrodes biomarker Computer applications to medicine. Medical informatics R858-859.7 Medical technology R855-855.5 Xuesong Luo Hilda Victoria Gutierrez Pulido Seward Rutkove Benjamin Sanchez A Bioimpedance-Based Device to Assess the Volume Conduction Properties of the Tongue in Neurological Disorders Affecting Bulbar function
description	<italic>Goal:</italic> Current instruments for bulbar assessment exhibit technical limitations that hinder the execution of clinical studies. The volume conduction properties (VCP) of the tongue reflect ionic content and myofiber integrity and they can serve as a new biomarker for evaluating neurological disorders with bulbar dysfunction. <italic>Methods:</italic> We designed a standalone bioimpedance measurement system that enables accurate, multi-frequency measurement of tongue anisotropic VCP including conductivity and relative permittivity. The system includes a tongue depressor with 16 non-invasive surface sensors for electrical contact with the tongue at directions 0<inline-formula><tex-math notation="LaTeX">$^{\circ }$</tex-math></inline-formula>, 45<inline-formula><tex-math notation="LaTeX">$^{\circ }$</tex-math></inline-formula>, 90<inline-formula><tex-math notation="LaTeX">$^{\circ }$</tex-math></inline-formula> and 150<inline-formula><tex-math notation="LaTeX">$^{\circ }$</tex-math></inline-formula>. The depressor is interfaced with the tongue electronic system with Bluetooth connectivity, and a smartphone application. De-identified patient data is sent by email. <italic>Results:</italic> We first determined the accuracy of the hardware performing phantom measurements mimicking a broad range of tongue values and determined the error to be <inline-formula><tex-math notation="LaTeX">$< $</tex-math></inline-formula>1%. We then validated our new technology measuring a cohort of 7 healthy human subjects under Institutional Review Board approval. <italic>Conclusions:</italic> None of the subjects who participated suffered discomfort or gag reflexes. The novel technique presented for intra-oral assessment of tongue VCP provides standard, objective and quantitative data potentially sensitive to alterations in tongue internal structure and composition.
format	article
author	Xuesong Luo Hilda Victoria Gutierrez Pulido Seward Rutkove Benjamin Sanchez
author_facet	Xuesong Luo Hilda Victoria Gutierrez Pulido Seward Rutkove Benjamin Sanchez
author_sort	Xuesong Luo
title	A Bioimpedance-Based Device to Assess the Volume Conduction Properties of the Tongue in Neurological Disorders Affecting Bulbar function
title_short	A Bioimpedance-Based Device to Assess the Volume Conduction Properties of the Tongue in Neurological Disorders Affecting Bulbar function
title_full	A Bioimpedance-Based Device to Assess the Volume Conduction Properties of the Tongue in Neurological Disorders Affecting Bulbar function
title_fullStr	A Bioimpedance-Based Device to Assess the Volume Conduction Properties of the Tongue in Neurological Disorders Affecting Bulbar function
title_full_unstemmed	A Bioimpedance-Based Device to Assess the Volume Conduction Properties of the Tongue in Neurological Disorders Affecting Bulbar function
title_sort	bioimpedance-based device to assess the volume conduction properties of the tongue in neurological disorders affecting bulbar function
publisher	IEEE
publishDate	2021
url	https://doaj.org/article/39fefe66a5e74c9eadce92f533ff654b
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A Bioimpedance-Based Device to Assess the Volume Conduction Properties of the Tongue in Neurological Disorders Affecting Bulbar function

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