High prevalence of Beijing and EAI4-VNM genotypes among M. tuberculosis isolates in northern Vietnam: sampling effect, rural and urban disparities.

A total of 221 isolates of M. tuberculosis were sampled from hospitals and the general population in the northern plain of Vietnam, one of the most populated region of the country. Genotypic composition and diversity were characterized, and we investigated how they are affected by sampling (hospital...

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Autores principales:	Van Anh Thi Nguyen, Marc Choisy, Duy Hung Nguyen, Thanh Hoa Thi Tran, Kim Lien Thi Pham, Phuong Thao Thi Dinh, Jules Philippe, Thai Son Nguyen, Minh Ly Ho, Sang Van Tran, Anne-Laure Bañuls, Duc Anh Dang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3a0131eb1e9f4625b5928e862b6faf88
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spelling	oai:doaj.org-article:3a0131eb1e9f4625b5928e862b6faf882021-11-18T07:04:22ZHigh prevalence of Beijing and EAI4-VNM genotypes among M. tuberculosis isolates in northern Vietnam: sampling effect, rural and urban disparities.1932-620310.1371/journal.pone.0045553https://doaj.org/article/3a0131eb1e9f4625b5928e862b6faf882012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23029091/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203A total of 221 isolates of M. tuberculosis were sampled from hospitals and the general population in the northern plain of Vietnam, one of the most populated region of the country. Genotypic composition and diversity were characterized, and we investigated how they are affected by sampling (hospital vs. general population), correcting for potential confounding effects (location, age and gender of the patients). Spoligotyping and 12 MIRU-VNTR typing were used as first line. Then 15 MIRU-VNTR standard set was used, making 21 MIRU-VNTR typing for the clustered isolates. Result showed that 8 lineages and 13 sub-lineages were circulating in the region. The most predominant lineages were Beijing (38.5%) and EAI (38.5%). Others appeared with small proportions H (1.4%), LAM (1.8%), T (8.1%), X (0.9%), MANU (2.3%), and Zero (0.4%). Higher clustering rate was found in the hospital samples (17.9% in urban and 19.2% in rural areas) compared to the population ones (0%). The typical Vietnamese EAI4-VNM sub-lineage of EAI lineage accounted for 67% of EAI strains and was associated with older ages. Beijing genotypes were associated with younger, urban population and were characterized by high clustering rates. These characteristics strongly suggest that Beijing strains are invading the population, replacing the local EAI-VNM4, thus predicting a more serious tuberculosis situation in the future in the absence of more effective control strategies.Van Anh Thi NguyenMarc ChoisyDuy Hung NguyenThanh Hoa Thi TranKim Lien Thi PhamPhuong Thao Thi DinhJules PhilippeThai Son NguyenMinh Ly HoSang Van TranAnne-Laure BañulsDuc Anh DangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e45553 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Van Anh Thi Nguyen Marc Choisy Duy Hung Nguyen Thanh Hoa Thi Tran Kim Lien Thi Pham Phuong Thao Thi Dinh Jules Philippe Thai Son Nguyen Minh Ly Ho Sang Van Tran Anne-Laure Bañuls Duc Anh Dang High prevalence of Beijing and EAI4-VNM genotypes among M. tuberculosis isolates in northern Vietnam: sampling effect, rural and urban disparities.
description	A total of 221 isolates of M. tuberculosis were sampled from hospitals and the general population in the northern plain of Vietnam, one of the most populated region of the country. Genotypic composition and diversity were characterized, and we investigated how they are affected by sampling (hospital vs. general population), correcting for potential confounding effects (location, age and gender of the patients). Spoligotyping and 12 MIRU-VNTR typing were used as first line. Then 15 MIRU-VNTR standard set was used, making 21 MIRU-VNTR typing for the clustered isolates. Result showed that 8 lineages and 13 sub-lineages were circulating in the region. The most predominant lineages were Beijing (38.5%) and EAI (38.5%). Others appeared with small proportions H (1.4%), LAM (1.8%), T (8.1%), X (0.9%), MANU (2.3%), and Zero (0.4%). Higher clustering rate was found in the hospital samples (17.9% in urban and 19.2% in rural areas) compared to the population ones (0%). The typical Vietnamese EAI4-VNM sub-lineage of EAI lineage accounted for 67% of EAI strains and was associated with older ages. Beijing genotypes were associated with younger, urban population and were characterized by high clustering rates. These characteristics strongly suggest that Beijing strains are invading the population, replacing the local EAI-VNM4, thus predicting a more serious tuberculosis situation in the future in the absence of more effective control strategies.
format	article
author	Van Anh Thi Nguyen Marc Choisy Duy Hung Nguyen Thanh Hoa Thi Tran Kim Lien Thi Pham Phuong Thao Thi Dinh Jules Philippe Thai Son Nguyen Minh Ly Ho Sang Van Tran Anne-Laure Bañuls Duc Anh Dang
author_facet	Van Anh Thi Nguyen Marc Choisy Duy Hung Nguyen Thanh Hoa Thi Tran Kim Lien Thi Pham Phuong Thao Thi Dinh Jules Philippe Thai Son Nguyen Minh Ly Ho Sang Van Tran Anne-Laure Bañuls Duc Anh Dang
author_sort	Van Anh Thi Nguyen
title	High prevalence of Beijing and EAI4-VNM genotypes among M. tuberculosis isolates in northern Vietnam: sampling effect, rural and urban disparities.
title_short	High prevalence of Beijing and EAI4-VNM genotypes among M. tuberculosis isolates in northern Vietnam: sampling effect, rural and urban disparities.
title_full	High prevalence of Beijing and EAI4-VNM genotypes among M. tuberculosis isolates in northern Vietnam: sampling effect, rural and urban disparities.
title_fullStr	High prevalence of Beijing and EAI4-VNM genotypes among M. tuberculosis isolates in northern Vietnam: sampling effect, rural and urban disparities.
title_full_unstemmed	High prevalence of Beijing and EAI4-VNM genotypes among M. tuberculosis isolates in northern Vietnam: sampling effect, rural and urban disparities.
title_sort	high prevalence of beijing and eai4-vnm genotypes among m. tuberculosis isolates in northern vietnam: sampling effect, rural and urban disparities.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/3a0131eb1e9f4625b5928e862b6faf88
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High prevalence of Beijing and EAI4-VNM genotypes among M. tuberculosis isolates in northern Vietnam: sampling effect, rural and urban disparities.

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