STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection

STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection

Cohesin is a multimeric nuclear protein complex which includes STAG2 and is associated with vital roles during cell division. Here in a genome-wide CRISPR-Cas9 screen, the authors identify a novel role of STAG2 as a crucial component of the innate immune response to rotavirus.

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Detalles Bibliográficos
Autores principales: Siyuan Ding, Jonathan Diep, Ningguo Feng, Lili Ren, Bin Li, Yaw Shin Ooi, Xin Wang, Kevin F. Brulois, Linda L. Yasukawa, Xingnan Li, Calvin J. Kuo, David A. Solomon, Jan E. Carette, Harry B. Greenberg
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/3a027c89acd64fe3a34c3ec69ad04b0a
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Sumario:Cohesin is a multimeric nuclear protein complex which includes STAG2 and is associated with vital roles during cell division. Here in a genome-wide CRISPR-Cas9 screen, the authors identify a novel role of STAG2 as a crucial component of the innate immune response to rotavirus.

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