STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection

Cohesin is a multimeric nuclear protein complex which includes STAG2 and is associated with vital roles during cell division. Here in a genome-wide CRISPR-Cas9 screen, the authors identify a novel role of STAG2 as a crucial component of the innate immune response to rotavirus.

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Autores principales:	Siyuan Ding, Jonathan Diep, Ningguo Feng, Lili Ren, Bin Li, Yaw Shin Ooi, Xin Wang, Kevin F. Brulois, Linda L. Yasukawa, Xingnan Li, Calvin J. Kuo, David A. Solomon, Jan E. Carette, Harry B. Greenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a027c89acd64fe3a34c3ec69ad04b0a
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spelling	oai:doaj.org-article:3a027c89acd64fe3a34c3ec69ad04b0a2021-12-02T17:33:17ZSTAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection10.1038/s41467-018-03782-z2041-1723https://doaj.org/article/3a027c89acd64fe3a34c3ec69ad04b0a2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03782-zhttps://doaj.org/toc/2041-1723Cohesin is a multimeric nuclear protein complex which includes STAG2 and is associated with vital roles during cell division. Here in a genome-wide CRISPR-Cas9 screen, the authors identify a novel role of STAG2 as a crucial component of the innate immune response to rotavirus.Siyuan DingJonathan DiepNingguo FengLili RenBin LiYaw Shin OoiXin WangKevin F. BruloisLinda L. YasukawaXingnan LiCalvin J. KuoDavid A. SolomonJan E. CaretteHarry B. GreenbergNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Siyuan Ding Jonathan Diep Ningguo Feng Lili Ren Bin Li Yaw Shin Ooi Xin Wang Kevin F. Brulois Linda L. Yasukawa Xingnan Li Calvin J. Kuo David A. Solomon Jan E. Carette Harry B. Greenberg STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection
description	Cohesin is a multimeric nuclear protein complex which includes STAG2 and is associated with vital roles during cell division. Here in a genome-wide CRISPR-Cas9 screen, the authors identify a novel role of STAG2 as a crucial component of the innate immune response to rotavirus.
format	article
author	Siyuan Ding Jonathan Diep Ningguo Feng Lili Ren Bin Li Yaw Shin Ooi Xin Wang Kevin F. Brulois Linda L. Yasukawa Xingnan Li Calvin J. Kuo David A. Solomon Jan E. Carette Harry B. Greenberg
author_facet	Siyuan Ding Jonathan Diep Ningguo Feng Lili Ren Bin Li Yaw Shin Ooi Xin Wang Kevin F. Brulois Linda L. Yasukawa Xingnan Li Calvin J. Kuo David A. Solomon Jan E. Carette Harry B. Greenberg
author_sort	Siyuan Ding
title	STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection
title_short	STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection
title_full	STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection
title_fullStr	STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection
title_full_unstemmed	STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection
title_sort	stag2 deficiency induces interferon responses via cgas-sting pathway and restricts virus infection
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3a027c89acd64fe3a34c3ec69ad04b0a
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STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection

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