Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration

Abstract Periodontitis is a chronic inflammatory disease that leads to the destruction of both soft and hard periodontal tissues. Complete periodontal regeneration in clinics using the currently available treatment approaches is still a challenge. Mesenchymal stem cells (MSCs) have shown promising p...

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Autores principales:	Hongbing Lin, Huishan Chen, Xuetao Zhao, Zhen Chen, Peipei Zhang, Yue Tian, Yawei Wang, Tong Ding, Lijing Wang, Yuqin Shen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Periodontal tissue regeneration Mesenchymal stem cells conditioned medium Osteogenesis Immunomodulation Angiogenesis Chemotaxis Medicine R
Acceso en línea:	https://doaj.org/article/3a03d5ba30bb4b37bfa9a0d84824569b
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spelling	oai:doaj.org-article:3a03d5ba30bb4b37bfa9a0d84824569b2021-11-07T12:08:21ZAdvances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration10.1186/s12967-021-03125-51479-5876https://doaj.org/article/3a03d5ba30bb4b37bfa9a0d84824569b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12967-021-03125-5https://doaj.org/toc/1479-5876Abstract Periodontitis is a chronic inflammatory disease that leads to the destruction of both soft and hard periodontal tissues. Complete periodontal regeneration in clinics using the currently available treatment approaches is still a challenge. Mesenchymal stem cells (MSCs) have shown promising potential to regenerate periodontal tissue in various preclinical and clinical studies. The poor survival rate of MSCs during in vivo transplantation and host immunogenic reaction towards MSCs are the main drawbacks of direct use of MSCs in periodontal tissue regeneration. Autologous MSCs have limited sources and possess patient morbidity during harvesting. Direct use of allogenic MSCs could induce host immune reaction. Therefore, the MSC-based indirect treatment approach could be beneficial for periodontal regeneration in clinics. MSC culture conditioned medium (CM) contains secretomes that had shown immunomodulatory and tissue regenerative potential in pre-clinical and clinical studies. MSC-CM contains a cocktail of growth factors, cytokines, chemokines, enzymes, and exosomes, extracellular vesicles, etc. MSC-CM-based indirect treatment has the potential to eliminate the drawbacks of direct use of MSCs for periodontal tissue regeneration. MSC-CM holds the tremendous potential of bench-to-bed translation in periodontal regeneration applications. This review focuses on the accumulating evidence indicating the therapeutic potential of the MSC-CM in periodontal regeneration-related pre-clinical and clinical studies. Recent advances on MSC-CM-based periodontal regeneration, existing challenges, and prospects are well summarized as guidance to improve the effectiveness of MSC-CM on periodontal regeneration in clinics.Hongbing LinHuishan ChenXuetao ZhaoZhen ChenPeipei ZhangYue TianYawei WangTong DingLijing WangYuqin ShenBMCarticlePeriodontal tissue regenerationMesenchymal stem cells conditioned mediumOsteogenesisImmunomodulationAngiogenesisChemotaxisMedicineRENJournal of Translational Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Periodontal tissue regeneration Mesenchymal stem cells conditioned medium Osteogenesis Immunomodulation Angiogenesis Chemotaxis Medicine R
spellingShingle	Periodontal tissue regeneration Mesenchymal stem cells conditioned medium Osteogenesis Immunomodulation Angiogenesis Chemotaxis Medicine R Hongbing Lin Huishan Chen Xuetao Zhao Zhen Chen Peipei Zhang Yue Tian Yawei Wang Tong Ding Lijing Wang Yuqin Shen Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration
description	Abstract Periodontitis is a chronic inflammatory disease that leads to the destruction of both soft and hard periodontal tissues. Complete periodontal regeneration in clinics using the currently available treatment approaches is still a challenge. Mesenchymal stem cells (MSCs) have shown promising potential to regenerate periodontal tissue in various preclinical and clinical studies. The poor survival rate of MSCs during in vivo transplantation and host immunogenic reaction towards MSCs are the main drawbacks of direct use of MSCs in periodontal tissue regeneration. Autologous MSCs have limited sources and possess patient morbidity during harvesting. Direct use of allogenic MSCs could induce host immune reaction. Therefore, the MSC-based indirect treatment approach could be beneficial for periodontal regeneration in clinics. MSC culture conditioned medium (CM) contains secretomes that had shown immunomodulatory and tissue regenerative potential in pre-clinical and clinical studies. MSC-CM contains a cocktail of growth factors, cytokines, chemokines, enzymes, and exosomes, extracellular vesicles, etc. MSC-CM-based indirect treatment has the potential to eliminate the drawbacks of direct use of MSCs for periodontal tissue regeneration. MSC-CM holds the tremendous potential of bench-to-bed translation in periodontal regeneration applications. This review focuses on the accumulating evidence indicating the therapeutic potential of the MSC-CM in periodontal regeneration-related pre-clinical and clinical studies. Recent advances on MSC-CM-based periodontal regeneration, existing challenges, and prospects are well summarized as guidance to improve the effectiveness of MSC-CM on periodontal regeneration in clinics.
format	article
author	Hongbing Lin Huishan Chen Xuetao Zhao Zhen Chen Peipei Zhang Yue Tian Yawei Wang Tong Ding Lijing Wang Yuqin Shen
author_facet	Hongbing Lin Huishan Chen Xuetao Zhao Zhen Chen Peipei Zhang Yue Tian Yawei Wang Tong Ding Lijing Wang Yuqin Shen
author_sort	Hongbing Lin
title	Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration
title_short	Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration
title_full	Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration
title_fullStr	Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration
title_full_unstemmed	Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration
title_sort	advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration
publisher	BMC
publishDate	2021
url	https://doaj.org/article/3a03d5ba30bb4b37bfa9a0d84824569b
work_keys_str_mv	AT hongbinglin advancesinmesenchymalstemcellconditionedmediummediatedperiodontaltissueregeneration AT huishanchen advancesinmesenchymalstemcellconditionedmediummediatedperiodontaltissueregeneration AT xuetaozhao advancesinmesenchymalstemcellconditionedmediummediatedperiodontaltissueregeneration AT zhenchen advancesinmesenchymalstemcellconditionedmediummediatedperiodontaltissueregeneration AT peipeizhang advancesinmesenchymalstemcellconditionedmediummediatedperiodontaltissueregeneration AT yuetian advancesinmesenchymalstemcellconditionedmediummediatedperiodontaltissueregeneration AT yaweiwang advancesinmesenchymalstemcellconditionedmediummediatedperiodontaltissueregeneration AT tongding advancesinmesenchymalstemcellconditionedmediummediatedperiodontaltissueregeneration AT lijingwang advancesinmesenchymalstemcellconditionedmediummediatedperiodontaltissueregeneration AT yuqinshen advancesinmesenchymalstemcellconditionedmediummediatedperiodontaltissueregeneration
_version_	1718443539460784128

Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration

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