IMMUNOHISTOCHEMICAL EXPRESSION OF ANDROGEN RECEPTOR IN TRIPLE NEGATIVE BREAST CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY, RAWALPINDI

Objective: To determine the frequency of immunohistochemical expression of androgen receptor in triple negative breast carcinoma. Study Design: Cross sectional study. Duration and Place of Study: This study included 30 cases confirmed as triple negative breast carcinoma at Armed Forces Institu...

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Autores principales:	Amna Ameer, Farhan Akhtar, Hafeez Ud Din, Rabia Ahmad
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	androgen receptor triple negative breast carcinoma breast carcinoma hormone receptors prognosis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3a03e5e7170d41fd84dadf6292624d28
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spelling	oai:doaj.org-article:3a03e5e7170d41fd84dadf6292624d282021-12-02T18:01:28ZIMMUNOHISTOCHEMICAL EXPRESSION OF ANDROGEN RECEPTOR IN TRIPLE NEGATIVE BREAST CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY, RAWALPINDI0030-96482411-884210.51253/pafmj.v71i1.4687https://doaj.org/article/3a03e5e7170d41fd84dadf6292624d282021-02-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/4687https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the frequency of immunohistochemical expression of androgen receptor in triple negative breast carcinoma. Study Design: Cross sectional study. Duration and Place of Study: This study included 30 cases confirmed as triple negative breast carcinoma at Armed Forces Institute of Pathology Rawalpindi, from Jan to Jul 2018. Methodology: Anti-androgen receptor antibody was applied and assessed. Positive expression was defined as greater and equal to 10% nuclear immunostaining. SPSS-24 was used for analyzing data. Results: Out of 30 cases of triple negative breast carcinoma (TNBC), all patients were female. Patients’ ages ranged between 21-72 years with a mean age of 46.35 years and a standard deviation of ± 13.4. Androgen receptor expression was positive in 8 cases (27%) of all triple negative breast carcinomas. Out of these androgen receptor (AR) triple negative breast carcinomas; all 8 cases were of histological subtype invasive ductal (mammary) carcinoma, non special type, 7 cases (23%) were of histological grade 3 and 1 was of histological grade 2. Conclusion: Androgen receptor expression is observed in 8 cases (27%) of triple negative breast carcinoma cases. Such patients can be selected as candidates for anti- androgen receptor targeted therapy.Amna AmeerFarhan AkhtarHafeez Ud DinRabia AhmadArmy Medical College Rawalpindiarticleandrogen receptortriple negative breast carcinomabreast carcinomahormone receptorsprognosisMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 1, Pp 7-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	androgen receptor triple negative breast carcinoma breast carcinoma hormone receptors prognosis Medicine R Medicine (General) R5-920
spellingShingle	androgen receptor triple negative breast carcinoma breast carcinoma hormone receptors prognosis Medicine R Medicine (General) R5-920 Amna Ameer Farhan Akhtar Hafeez Ud Din Rabia Ahmad IMMUNOHISTOCHEMICAL EXPRESSION OF ANDROGEN RECEPTOR IN TRIPLE NEGATIVE BREAST CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY, RAWALPINDI
description	Objective: To determine the frequency of immunohistochemical expression of androgen receptor in triple negative breast carcinoma. Study Design: Cross sectional study. Duration and Place of Study: This study included 30 cases confirmed as triple negative breast carcinoma at Armed Forces Institute of Pathology Rawalpindi, from Jan to Jul 2018. Methodology: Anti-androgen receptor antibody was applied and assessed. Positive expression was defined as greater and equal to 10% nuclear immunostaining. SPSS-24 was used for analyzing data. Results: Out of 30 cases of triple negative breast carcinoma (TNBC), all patients were female. Patients’ ages ranged between 21-72 years with a mean age of 46.35 years and a standard deviation of ± 13.4. Androgen receptor expression was positive in 8 cases (27%) of all triple negative breast carcinomas. Out of these androgen receptor (AR) triple negative breast carcinomas; all 8 cases were of histological subtype invasive ductal (mammary) carcinoma, non special type, 7 cases (23%) were of histological grade 3 and 1 was of histological grade 2. Conclusion: Androgen receptor expression is observed in 8 cases (27%) of triple negative breast carcinoma cases. Such patients can be selected as candidates for anti- androgen receptor targeted therapy.
format	article
author	Amna Ameer Farhan Akhtar Hafeez Ud Din Rabia Ahmad
author_facet	Amna Ameer Farhan Akhtar Hafeez Ud Din Rabia Ahmad
author_sort	Amna Ameer
title	IMMUNOHISTOCHEMICAL EXPRESSION OF ANDROGEN RECEPTOR IN TRIPLE NEGATIVE BREAST CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY, RAWALPINDI
title_short	IMMUNOHISTOCHEMICAL EXPRESSION OF ANDROGEN RECEPTOR IN TRIPLE NEGATIVE BREAST CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY, RAWALPINDI
title_full	IMMUNOHISTOCHEMICAL EXPRESSION OF ANDROGEN RECEPTOR IN TRIPLE NEGATIVE BREAST CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY, RAWALPINDI
title_fullStr	IMMUNOHISTOCHEMICAL EXPRESSION OF ANDROGEN RECEPTOR IN TRIPLE NEGATIVE BREAST CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY, RAWALPINDI
title_full_unstemmed	IMMUNOHISTOCHEMICAL EXPRESSION OF ANDROGEN RECEPTOR IN TRIPLE NEGATIVE BREAST CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY, RAWALPINDI
title_sort	immunohistochemical expression of androgen receptor in triple negative breast carcinoma at armed forces institute of pathology, rawalpindi
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/3a03e5e7170d41fd84dadf6292624d28
work_keys_str_mv	AT amnaameer immunohistochemicalexpressionofandrogenreceptorintriplenegativebreastcarcinomaatarmedforcesinstituteofpathologyrawalpindi AT farhanakhtar immunohistochemicalexpressionofandrogenreceptorintriplenegativebreastcarcinomaatarmedforcesinstituteofpathologyrawalpindi AT hafeezuddin immunohistochemicalexpressionofandrogenreceptorintriplenegativebreastcarcinomaatarmedforcesinstituteofpathologyrawalpindi AT rabiaahmad immunohistochemicalexpressionofandrogenreceptorintriplenegativebreastcarcinomaatarmedforcesinstituteofpathologyrawalpindi
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IMMUNOHISTOCHEMICAL EXPRESSION OF ANDROGEN RECEPTOR IN TRIPLE NEGATIVE BREAST CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY, RAWALPINDI

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