The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization
The nuclear envelope tethers chromatin to the nuclear periphery to control genome architecture. Here, the authors show that Net39 preserves the integrity and gene expression of muscle nuclei in mice, and it may contribute to the pathogenesis of Emery–Dreifuss muscular dystrophy.
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Nature Portfolio
2021
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oai:doaj.org-article:3a056dc3d882494d8fb0ecf911b951c92021-12-02T13:24:33ZThe nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization10.1038/s41467-021-20987-x2041-1723https://doaj.org/article/3a056dc3d882494d8fb0ecf911b951c92021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20987-xhttps://doaj.org/toc/2041-1723The nuclear envelope tethers chromatin to the nuclear periphery to control genome architecture. Here, the authors show that Net39 preserves the integrity and gene expression of muscle nuclei in mice, and it may contribute to the pathogenesis of Emery–Dreifuss muscular dystrophy.Andres Ramirez-MartinezYichi ZhangKenian ChenJiwoong KimBercin K. CenikJohn R. McAnallyChunyu CaiJohn M. SheltonJian HuangAna BrennanBret M. EversPradeep P. A. MammenLin XuRhonda Bassel-DubyNing LiuEric N. OlsonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Andres Ramirez-Martinez Yichi Zhang Kenian Chen Jiwoong Kim Bercin K. Cenik John R. McAnally Chunyu Cai John M. Shelton Jian Huang Ana Brennan Bret M. Evers Pradeep P. A. Mammen Lin Xu Rhonda Bassel-Duby Ning Liu Eric N. Olson The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization |
| description |
The nuclear envelope tethers chromatin to the nuclear periphery to control genome architecture. Here, the authors show that Net39 preserves the integrity and gene expression of muscle nuclei in mice, and it may contribute to the pathogenesis of Emery–Dreifuss muscular dystrophy. |
| format |
article |
| author |
Andres Ramirez-Martinez Yichi Zhang Kenian Chen Jiwoong Kim Bercin K. Cenik John R. McAnally Chunyu Cai John M. Shelton Jian Huang Ana Brennan Bret M. Evers Pradeep P. A. Mammen Lin Xu Rhonda Bassel-Duby Ning Liu Eric N. Olson |
| author_facet |
Andres Ramirez-Martinez Yichi Zhang Kenian Chen Jiwoong Kim Bercin K. Cenik John R. McAnally Chunyu Cai John M. Shelton Jian Huang Ana Brennan Bret M. Evers Pradeep P. A. Mammen Lin Xu Rhonda Bassel-Duby Ning Liu Eric N. Olson |
| author_sort |
Andres Ramirez-Martinez |
| title |
The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization |
| title_short |
The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization |
| title_full |
The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization |
| title_fullStr |
The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization |
| title_full_unstemmed |
The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization |
| title_sort |
nuclear envelope protein net39 is essential for muscle nuclear integrity and chromatin organization |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/3a056dc3d882494d8fb0ecf911b951c9 |
| work_keys_str_mv |
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| _version_ |
1718393088947257344 |