Significant elevation of aqueous endothelin-1 in central retinal vein occlusion.

<h4>Purpose</h4>To investigate aqueous humor concentrations of endothelin-1 (ET-1) in patients with central retinal vein occlusion (CRVO) compared with patients with branch retinal vein occlusion (BRVO) and a normal control group.<h4>Methods</h4>A total 80 subjects were inclu...

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Autores principales:	Hae Min Kang, Md Hasanuzzaman, So Won Kim, Hyoung Jun Koh, Sung Chul Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3a094fd5bfc244f286828f36ec42967b
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spelling	oai:doaj.org-article:3a094fd5bfc244f286828f36ec42967b2021-12-02T20:07:20ZSignificant elevation of aqueous endothelin-1 in central retinal vein occlusion.1932-620310.1371/journal.pone.0252530https://doaj.org/article/3a094fd5bfc244f286828f36ec42967b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252530https://doaj.org/toc/1932-6203<h4>Purpose</h4>To investigate aqueous humor concentrations of endothelin-1 (ET-1) in patients with central retinal vein occlusion (CRVO) compared with patients with branch retinal vein occlusion (BRVO) and a normal control group.<h4>Methods</h4>A total 80 subjects were included in this prospective study, including 15 patients with CRVO, 20 patients with BRVO, and 45 patients who underwent cataract surgery and had no concomitant ocular disease. Aqueous humor levels of ET-1 were obtained before intravitreal bevacizumab injection (IVB) and after 1 month.<h4>Results</h4>At baseline, the mean aqueous ET-1 level was 12.7±3.6 pg/mL in the CRVO group, 8.0±2.3 pg/mL in the BRVO group, and 2.0±0.9 pg/mL in the control group (P<0.001). After IVB, the mean aqueous level of ET-1 was 3.4±1.9 pg/mL (0.5-6.9 pg/mL) in the CRVO group and 1.8±1.0 pg/mL (0.3-3.2 pg/mL) in the BRVO group (P = 0.008). The mean aqueous ET-1 level was significantly reduced in both the patients with CRVO and those with BRVO (P<0.001).<h4>Conclusion</h4>The mean aqueous humor ET-1 level was significant higher in the patients with CRVO than those with BRVO and in the control group. After IVB, the mean level was significantly reduced in both the patients with CRVO and those with BRVO.Hae Min KangMd HasanuzzamanSo Won KimHyoung Jun KohSung Chul LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252530 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hae Min Kang Md Hasanuzzaman So Won Kim Hyoung Jun Koh Sung Chul Lee Significant elevation of aqueous endothelin-1 in central retinal vein occlusion.
description	<h4>Purpose</h4>To investigate aqueous humor concentrations of endothelin-1 (ET-1) in patients with central retinal vein occlusion (CRVO) compared with patients with branch retinal vein occlusion (BRVO) and a normal control group.<h4>Methods</h4>A total 80 subjects were included in this prospective study, including 15 patients with CRVO, 20 patients with BRVO, and 45 patients who underwent cataract surgery and had no concomitant ocular disease. Aqueous humor levels of ET-1 were obtained before intravitreal bevacizumab injection (IVB) and after 1 month.<h4>Results</h4>At baseline, the mean aqueous ET-1 level was 12.7±3.6 pg/mL in the CRVO group, 8.0±2.3 pg/mL in the BRVO group, and 2.0±0.9 pg/mL in the control group (P<0.001). After IVB, the mean aqueous level of ET-1 was 3.4±1.9 pg/mL (0.5-6.9 pg/mL) in the CRVO group and 1.8±1.0 pg/mL (0.3-3.2 pg/mL) in the BRVO group (P = 0.008). The mean aqueous ET-1 level was significantly reduced in both the patients with CRVO and those with BRVO (P<0.001).<h4>Conclusion</h4>The mean aqueous humor ET-1 level was significant higher in the patients with CRVO than those with BRVO and in the control group. After IVB, the mean level was significantly reduced in both the patients with CRVO and those with BRVO.
format	article
author	Hae Min Kang Md Hasanuzzaman So Won Kim Hyoung Jun Koh Sung Chul Lee
author_facet	Hae Min Kang Md Hasanuzzaman So Won Kim Hyoung Jun Koh Sung Chul Lee
author_sort	Hae Min Kang
title	Significant elevation of aqueous endothelin-1 in central retinal vein occlusion.
title_short	Significant elevation of aqueous endothelin-1 in central retinal vein occlusion.
title_full	Significant elevation of aqueous endothelin-1 in central retinal vein occlusion.
title_fullStr	Significant elevation of aqueous endothelin-1 in central retinal vein occlusion.
title_full_unstemmed	Significant elevation of aqueous endothelin-1 in central retinal vein occlusion.
title_sort	significant elevation of aqueous endothelin-1 in central retinal vein occlusion.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3a094fd5bfc244f286828f36ec42967b
work_keys_str_mv	AT haeminkang significantelevationofaqueousendothelin1incentralretinalveinocclusion AT mdhasanuzzaman significantelevationofaqueousendothelin1incentralretinalveinocclusion AT sowonkim significantelevationofaqueousendothelin1incentralretinalveinocclusion AT hyoungjunkoh significantelevationofaqueousendothelin1incentralretinalveinocclusion AT sungchullee significantelevationofaqueousendothelin1incentralretinalveinocclusion
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Significant elevation of aqueous endothelin-1 in central retinal vein occlusion.

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