Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application

Abstract. Lack of clarity of the mechanisms that underlie leukemogenesis obstructs the diagnosis, prognosis, and treatment of leukemia. Research has found that small nuclear RNA (snoRNA) plays an essential role in leukemia. These small non-coding RNAs are involved in ribosome biogenesis, including t...

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Autores principales:	Li-Min Lin, Qi Pan, Yu-Meng Sun, Wen-Tao Wang
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Health 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/3a0c25126c1043e3b5a5beb7890b3563
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spelling	oai:doaj.org-article:3a0c25126c1043e3b5a5beb7890b35632021-11-25T07:49:34ZSmall nucleolar RNA is potential as a novel player in leukemogenesis and clinical application2543-636810.1097/BS9.0000000000000091https://doaj.org/article/3a0c25126c1043e3b5a5beb7890b35632021-10-01T00:00:00Zhttp://journals.lww.com/10.1097/BS9.0000000000000091https://doaj.org/toc/2543-6368Abstract. Lack of clarity of the mechanisms that underlie leukemogenesis obstructs the diagnosis, prognosis, and treatment of leukemia. Research has found that small nuclear RNA (snoRNA) plays an essential role in leukemia. These small non-coding RNAs are involved in ribosome biogenesis, including the 2′-O-methylation and pseudouridylation of precursor ribosomal RNA (pre-rRNA), and pre-rRNA splicing. Recently, many snoRNAs were found to be orphans that have no predictable RNA modification targets, but these RNAs have always been found to be located in different subcellular organelles, and they play diverse roles. Using high-throughput technology, snoRNA expression profiles have been revealed in leukemia, and some of the deregulated snoRNAs may regulate the cell cycle, differentiation, proliferation, and apoptosis in leukemic cells and confer drug resistance during leukemia treatment. In this review, we discuss the expression profiles and functions of snoRNAs, particularly orphan snoRNAs, in leukemia. It is possible that the dysregulated snoRNAs are promising diagnosis and prognosis markers for leukemia, which may serve as potential therapeutic targets in leukemia treatment.Li-Min LinQi PanYu-Meng SunWen-Tao WangWolters Kluwer HealtharticleDiseases of the blood and blood-forming organsRC633-647.5ENBlood Science, Vol 3, Iss 4, Pp 122-131 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Li-Min Lin Qi Pan Yu-Meng Sun Wen-Tao Wang Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application
description	Abstract. Lack of clarity of the mechanisms that underlie leukemogenesis obstructs the diagnosis, prognosis, and treatment of leukemia. Research has found that small nuclear RNA (snoRNA) plays an essential role in leukemia. These small non-coding RNAs are involved in ribosome biogenesis, including the 2′-O-methylation and pseudouridylation of precursor ribosomal RNA (pre-rRNA), and pre-rRNA splicing. Recently, many snoRNAs were found to be orphans that have no predictable RNA modification targets, but these RNAs have always been found to be located in different subcellular organelles, and they play diverse roles. Using high-throughput technology, snoRNA expression profiles have been revealed in leukemia, and some of the deregulated snoRNAs may regulate the cell cycle, differentiation, proliferation, and apoptosis in leukemic cells and confer drug resistance during leukemia treatment. In this review, we discuss the expression profiles and functions of snoRNAs, particularly orphan snoRNAs, in leukemia. It is possible that the dysregulated snoRNAs are promising diagnosis and prognosis markers for leukemia, which may serve as potential therapeutic targets in leukemia treatment.
format	article
author	Li-Min Lin Qi Pan Yu-Meng Sun Wen-Tao Wang
author_facet	Li-Min Lin Qi Pan Yu-Meng Sun Wen-Tao Wang
author_sort	Li-Min Lin
title	Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application
title_short	Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application
title_full	Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application
title_fullStr	Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application
title_full_unstemmed	Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application
title_sort	small nucleolar rna is potential as a novel player in leukemogenesis and clinical application
publisher	Wolters Kluwer Health
publishDate	2021
url	https://doaj.org/article/3a0c25126c1043e3b5a5beb7890b3563
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Small nucleolar RNA is potential as a novel player in leukemogenesis and clinical application

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