Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy

Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy

Identifying pathways that cause pathological cardiac hypertrophy holds great therapeutic potential. Here the authors discover one such pathway and show that SIKE, an inhibitor of interferon signalling, prevents pathological but not physiological cardiac hypertrophy by interacting with TBK1 and modul...

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Autores principales: Ke-Qiong Deng, Aibing Wang, Yan-Xiao Ji, Xiao-Jing Zhang, Jing Fang, Yan Zhang, Peng Zhang, Xi Jiang, Lu Gao, Xue-Yong Zhu, Yichao Zhao, Lingchen Gao, Qinglin Yang, Xue-Hai Zhu, Xiang Wei, Jun Pu, Hongliang Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/3a0ceb3a62dc4aea8e77bd44a26b3573
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spelling oai:doaj.org-article:3a0ceb3a62dc4aea8e77bd44a26b35732021-12-02T17:33:07ZSuppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy10.1038/ncomms114322041-1723https://doaj.org/article/3a0ceb3a62dc4aea8e77bd44a26b35732016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11432https://doaj.org/toc/2041-1723Identifying pathways that cause pathological cardiac hypertrophy holds great therapeutic potential. Here the authors discover one such pathway and show that SIKE, an inhibitor of interferon signalling, prevents pathological but not physiological cardiac hypertrophy by interacting with TBK1 and modulating the TBK1/AKT signalling in rodents and monkeys.Ke-Qiong DengAibing WangYan-Xiao JiXiao-Jing ZhangJing FangYan ZhangPeng ZhangXi JiangLu GaoXue-Yong ZhuYichao ZhaoLingchen GaoQinglin YangXue-Hai ZhuXiang WeiJun PuHongliang LiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-21 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ke-Qiong Deng
Aibing Wang
Yan-Xiao Ji
Xiao-Jing Zhang
Jing Fang
Yan Zhang
Peng Zhang
Xi Jiang
Lu Gao
Xue-Yong Zhu
Yichao Zhao
Lingchen Gao
Qinglin Yang
Xue-Hai Zhu
Xiang Wei
Jun Pu
Hongliang Li
Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy
description Identifying pathways that cause pathological cardiac hypertrophy holds great therapeutic potential. Here the authors discover one such pathway and show that SIKE, an inhibitor of interferon signalling, prevents pathological but not physiological cardiac hypertrophy by interacting with TBK1 and modulating the TBK1/AKT signalling in rodents and monkeys.
format article
author Ke-Qiong Deng
Aibing Wang
Yan-Xiao Ji
Xiao-Jing Zhang
Jing Fang
Yan Zhang
Peng Zhang
Xi Jiang
Lu Gao
Xue-Yong Zhu
Yichao Zhao
Lingchen Gao
Qinglin Yang
Xue-Hai Zhu
Xiang Wei
Jun Pu
Hongliang Li
author_facet Ke-Qiong Deng
Aibing Wang
Yan-Xiao Ji
Xiao-Jing Zhang
Jing Fang
Yan Zhang
Peng Zhang
Xi Jiang
Lu Gao
Xue-Yong Zhu
Yichao Zhao
Lingchen Gao
Qinglin Yang
Xue-Hai Zhu
Xiang Wei
Jun Pu
Hongliang Li
author_sort Ke-Qiong Deng
title Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy
title_short Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy
title_full Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy
title_fullStr Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy
title_full_unstemmed Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy
title_sort suppressor of ikkɛ is an essential negative regulator of pathological cardiac hypertrophy
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/3a0ceb3a62dc4aea8e77bd44a26b3573
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AT yanxiaoji suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
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AT lugao suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
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AT hongliangli suppressorofikkɛisanessentialnegativeregulatorofpathologicalcardiachypertrophy
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