High prevalence of genotype B0/W148 of Mycobacterium tuberculosis among HIV-TB patients in Perm Krai and Irkutsk Region

Background. The population with HIV-infection plays significant role in ongoing tuberculosis pandemic. Immunosuppression due to HIV-infection is one of the causes of TB disseminated forms in this group of people. Having low immune status is also often associated with a polyclonal M. tuberculosis inf...

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Autores principales:	O. E. Mikova, S. N. Zhdanova, V. I. Sergevnin, O. B. Ogarkov, T. V. Sarmometov, T. A. Varetskaya, O. N. Novitskaya, P. A. Chromova, E. D. Savilov, M. Y. Koshcheev, D. V. Shmagin
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	m. tuberculosis tuberculosis genotype beijing Science Q
Acceso en línea:	https://doaj.org/article/3a0e15224c7f450fa3ebe512c707dc9a
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spelling	oai:doaj.org-article:3a0e15224c7f450fa3ebe512c707dc9a2021-11-23T06:14:36ZHigh prevalence of genotype B0/W148 of Mycobacterium tuberculosis among HIV-TB patients in Perm Krai and Irkutsk Region2541-94202587-959610.12737/23412https://doaj.org/article/3a0e15224c7f450fa3ebe512c707dc9a2016-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/297https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. The population with HIV-infection plays significant role in ongoing tuberculosis pandemic. Immunosuppression due to HIV-infection is one of the causes of TB disseminated forms in this group of people. Having low immune status is also often associated with a polyclonal M. tuberculosis infection. Aim of the research: comparative assessment of epidemic genotypes of M. tuberculosis prevalence and mixed genotypes identification within HlV-TB co-infected patients in two Russian regions. Materials and methods. The DNAs of 78 clinical isolates from Irkutsk Region (IR) and 64 strains from Perm Krai (PK) have been genotyped by MIRU VNTR 24 and RD105/RD207. Strains were obtained from patients who did not have significant age and sex differences. In the PK age of the patients was 34.5 ± 0.9, in IR - 34.4 ± 1.5 years. The samples were obtained from 67.2 and 65.4 % of men, respectively. Result. The study of the M. tuberculosis indicates significant predominance of Beijing genotype strains in patients with TB-HIV of PK (92.2 %) compared to the IR (59.5 %) (х2 = 18.0; p < 0.01). The prevalence of MDR pathogens in TB-HIV patients exceeded 50 %. The mixed genotype detection in the PK and IR was high (14.1 and 12.7 % respectively). The level of virulent strains B0/W148 was 34.4 % in PK patients and 25.3 % in IR ones. Analysis of the results suggests the epidemic spread of MDR-TB in the immunocompromised individuals. Conclusions: The identified trends may indicate that Perm Kray have a process of active dissemination of transmissible strains of M. tuberculosis within HIV-infected population.O. E. MikovaS. N. ZhdanovaV. I. SergevninO. B. OgarkovT. V. SarmometovT. A. VaretskayaO. N. NovitskayaP. A. ChromovaE. D. SavilovM. Y. KoshcheevD. V. ShmaginScientific Сentre for Family Health and Human Reproduction Problemsarticlem. tuberculosistuberculosisgenotype beijingm. tuberculosisScienceQRUActa Biomedica Scientifica, Vol 1, Iss 5, Pp 142-145 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	m. tuberculosis tuberculosis genotype beijing m. tuberculosis Science Q
spellingShingle	m. tuberculosis tuberculosis genotype beijing m. tuberculosis Science Q O. E. Mikova S. N. Zhdanova V. I. Sergevnin O. B. Ogarkov T. V. Sarmometov T. A. Varetskaya O. N. Novitskaya P. A. Chromova E. D. Savilov M. Y. Koshcheev D. V. Shmagin High prevalence of genotype B0/W148 of Mycobacterium tuberculosis among HIV-TB patients in Perm Krai and Irkutsk Region
description	Background. The population with HIV-infection plays significant role in ongoing tuberculosis pandemic. Immunosuppression due to HIV-infection is one of the causes of TB disseminated forms in this group of people. Having low immune status is also often associated with a polyclonal M. tuberculosis infection. Aim of the research: comparative assessment of epidemic genotypes of M. tuberculosis prevalence and mixed genotypes identification within HlV-TB co-infected patients in two Russian regions. Materials and methods. The DNAs of 78 clinical isolates from Irkutsk Region (IR) and 64 strains from Perm Krai (PK) have been genotyped by MIRU VNTR 24 and RD105/RD207. Strains were obtained from patients who did not have significant age and sex differences. In the PK age of the patients was 34.5 ± 0.9, in IR - 34.4 ± 1.5 years. The samples were obtained from 67.2 and 65.4 % of men, respectively. Result. The study of the M. tuberculosis indicates significant predominance of Beijing genotype strains in patients with TB-HIV of PK (92.2 %) compared to the IR (59.5 %) (х2 = 18.0; p < 0.01). The prevalence of MDR pathogens in TB-HIV patients exceeded 50 %. The mixed genotype detection in the PK and IR was high (14.1 and 12.7 % respectively). The level of virulent strains B0/W148 was 34.4 % in PK patients and 25.3 % in IR ones. Analysis of the results suggests the epidemic spread of MDR-TB in the immunocompromised individuals. Conclusions: The identified trends may indicate that Perm Kray have a process of active dissemination of transmissible strains of M. tuberculosis within HIV-infected population.
format	article
author	O. E. Mikova S. N. Zhdanova V. I. Sergevnin O. B. Ogarkov T. V. Sarmometov T. A. Varetskaya O. N. Novitskaya P. A. Chromova E. D. Savilov M. Y. Koshcheev D. V. Shmagin
author_facet	O. E. Mikova S. N. Zhdanova V. I. Sergevnin O. B. Ogarkov T. V. Sarmometov T. A. Varetskaya O. N. Novitskaya P. A. Chromova E. D. Savilov M. Y. Koshcheev D. V. Shmagin
author_sort	O. E. Mikova
title	High prevalence of genotype B0/W148 of Mycobacterium tuberculosis among HIV-TB patients in Perm Krai and Irkutsk Region
title_short	High prevalence of genotype B0/W148 of Mycobacterium tuberculosis among HIV-TB patients in Perm Krai and Irkutsk Region
title_full	High prevalence of genotype B0/W148 of Mycobacterium tuberculosis among HIV-TB patients in Perm Krai and Irkutsk Region
title_fullStr	High prevalence of genotype B0/W148 of Mycobacterium tuberculosis among HIV-TB patients in Perm Krai and Irkutsk Region
title_full_unstemmed	High prevalence of genotype B0/W148 of Mycobacterium tuberculosis among HIV-TB patients in Perm Krai and Irkutsk Region
title_sort	high prevalence of genotype b0/w148 of mycobacterium tuberculosis among hiv-tb patients in perm krai and irkutsk region
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/3a0e15224c7f450fa3ebe512c707dc9a
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High prevalence of genotype B0/W148 of Mycobacterium tuberculosis among HIV-TB patients in Perm Krai and Irkutsk Region

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