Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

Genome-wide association studies (GWAS) have identified hundreds of genomic risk regions for prostate cancer. Here, the authors perform a transcriptome wide association study (TWAS) by incorporating prostate cancer GWAS with gene expression data to identify potential novel prostate cancer risk loci a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nicholas Mancuso, Simon Gayther, Alexander Gusev, Wei Zheng, Kathryn L. Penney, Zsofia Kote-Jarai, Rosalind Eeles, Matthew Freedman, Christopher Haiman, Bogdan Pasaniuc, The PRACTICAL consortium
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a0f40e6d6d44e80b0ffa6ede91c2038
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3a0f40e6d6d44e80b0ffa6ede91c2038
record_format	dspace
spelling	oai:doaj.org-article:3a0f40e6d6d44e80b0ffa6ede91c20382021-12-02T14:41:27ZLarge-scale transcriptome-wide association study identifies new prostate cancer risk regions10.1038/s41467-018-06302-12041-1723https://doaj.org/article/3a0f40e6d6d44e80b0ffa6ede91c20382018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06302-1https://doaj.org/toc/2041-1723Genome-wide association studies (GWAS) have identified hundreds of genomic risk regions for prostate cancer. Here, the authors perform a transcriptome wide association study (TWAS) by incorporating prostate cancer GWAS with gene expression data to identify potential novel prostate cancer risk loci and possible risk mechanisms.Nicholas MancusoSimon GaytherAlexander GusevWei ZhengKathryn L. PenneyZsofia Kote-JaraiRosalind EelesMatthew FreedmanChristopher HaimanBogdan PasaniucThe PRACTICAL consortiumNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas Mancuso Simon Gayther Alexander Gusev Wei Zheng Kathryn L. Penney Zsofia Kote-Jarai Rosalind Eeles Matthew Freedman Christopher Haiman Bogdan Pasaniuc The PRACTICAL consortium Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
description	Genome-wide association studies (GWAS) have identified hundreds of genomic risk regions for prostate cancer. Here, the authors perform a transcriptome wide association study (TWAS) by incorporating prostate cancer GWAS with gene expression data to identify potential novel prostate cancer risk loci and possible risk mechanisms.
format	article
author	Nicholas Mancuso Simon Gayther Alexander Gusev Wei Zheng Kathryn L. Penney Zsofia Kote-Jarai Rosalind Eeles Matthew Freedman Christopher Haiman Bogdan Pasaniuc The PRACTICAL consortium
author_facet	Nicholas Mancuso Simon Gayther Alexander Gusev Wei Zheng Kathryn L. Penney Zsofia Kote-Jarai Rosalind Eeles Matthew Freedman Christopher Haiman Bogdan Pasaniuc The PRACTICAL consortium
author_sort	Nicholas Mancuso
title	Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
title_short	Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
title_full	Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
title_fullStr	Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
title_full_unstemmed	Large-scale transcriptome-wide association study identifies new prostate cancer risk regions
title_sort	large-scale transcriptome-wide association study identifies new prostate cancer risk regions
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3a0f40e6d6d44e80b0ffa6ede91c2038
work_keys_str_mv	AT nicholasmancuso largescaletranscriptomewideassociationstudyidentifiesnewprostatecancerriskregions AT simongayther largescaletranscriptomewideassociationstudyidentifiesnewprostatecancerriskregions AT alexandergusev largescaletranscriptomewideassociationstudyidentifiesnewprostatecancerriskregions AT weizheng largescaletranscriptomewideassociationstudyidentifiesnewprostatecancerriskregions AT kathrynlpenney largescaletranscriptomewideassociationstudyidentifiesnewprostatecancerriskregions AT zsofiakotejarai largescaletranscriptomewideassociationstudyidentifiesnewprostatecancerriskregions AT rosalindeeles largescaletranscriptomewideassociationstudyidentifiesnewprostatecancerriskregions AT matthewfreedman largescaletranscriptomewideassociationstudyidentifiesnewprostatecancerriskregions AT christopherhaiman largescaletranscriptomewideassociationstudyidentifiesnewprostatecancerriskregions AT bogdanpasaniuc largescaletranscriptomewideassociationstudyidentifiesnewprostatecancerriskregions AT thepracticalconsortium largescaletranscriptomewideassociationstudyidentifiesnewprostatecancerriskregions
_version_	1718389864107343872

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

Ejemplares similares