Beneficial Effects of Ursolic Acid and Its Derivatives—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

Ursolic acid (UA) is a natural pentacyclic triterpenoid found in a number of plants such as apples, thyme, oregano, hawthorn and others. Several in vitro and in vivo studies have presented its anti-inflammatory and anti-apoptotic properties. The inhibition of NF-κB-mediated inflammatory pathways and...

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Autores principales:	Jakub Erdmann, Marcin Kujaciński, Michał Wiciński
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ursolic acid pentacyclic triterpenoid cardiovascular disease atherosclerosis cardiac fibrosis aneurysm Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/3a10991c74ec40a4b91dd12810b15e4c
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spelling	oai:doaj.org-article:3a10991c74ec40a4b91dd12810b15e4c2021-11-25T18:35:06ZBeneficial Effects of Ursolic Acid and Its Derivatives—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions10.3390/nu131139002072-6643https://doaj.org/article/3a10991c74ec40a4b91dd12810b15e4c2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3900https://doaj.org/toc/2072-6643Ursolic acid (UA) is a natural pentacyclic triterpenoid found in a number of plants such as apples, thyme, oregano, hawthorn and others. Several in vitro and in vivo studies have presented its anti-inflammatory and anti-apoptotic properties. The inhibition of NF-κB-mediated inflammatory pathways and the increased scavenging of reactive oxygen species (ROS) in numerous ways seem to be the most beneficial effects of UA. In mice and rats, administration of UA appears to slow down the development of cardiovascular diseases (CVDs), especially atherosclerosis and cardiac fibrosis. Upregulation of endothelial-type nitric oxide synthase (eNOS) and cystathionine-λ-lyase (CSE) by UA may suggest its vasorelaxant property. Inhibition of metalloproteinases activity by UA may contribute to better outcomes in aneurysms management. UA influence on lipid and glucose metabolism remains inconsistent, and additional studies are essential to verify its efficacy. Furthermore, UA derivatives appear to have a beneficial impact on the cardiovascular system. This review aims to summarize recent findings on beneficial effects of UA that may make it a promising candidate for clinical trials for the management of CVDs.Jakub ErdmannMarcin KujacińskiMichał WicińskiMDPI AGarticleursolic acidpentacyclic triterpenoidcardiovascular diseaseatherosclerosiscardiac fibrosisaneurysmNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3900, p 3900 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ursolic acid pentacyclic triterpenoid cardiovascular disease atherosclerosis cardiac fibrosis aneurysm Nutrition. Foods and food supply TX341-641
spellingShingle	ursolic acid pentacyclic triterpenoid cardiovascular disease atherosclerosis cardiac fibrosis aneurysm Nutrition. Foods and food supply TX341-641 Jakub Erdmann Marcin Kujaciński Michał Wiciński Beneficial Effects of Ursolic Acid and Its Derivatives—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions
description	Ursolic acid (UA) is a natural pentacyclic triterpenoid found in a number of plants such as apples, thyme, oregano, hawthorn and others. Several in vitro and in vivo studies have presented its anti-inflammatory and anti-apoptotic properties. The inhibition of NF-κB-mediated inflammatory pathways and the increased scavenging of reactive oxygen species (ROS) in numerous ways seem to be the most beneficial effects of UA. In mice and rats, administration of UA appears to slow down the development of cardiovascular diseases (CVDs), especially atherosclerosis and cardiac fibrosis. Upregulation of endothelial-type nitric oxide synthase (eNOS) and cystathionine-λ-lyase (CSE) by UA may suggest its vasorelaxant property. Inhibition of metalloproteinases activity by UA may contribute to better outcomes in aneurysms management. UA influence on lipid and glucose metabolism remains inconsistent, and additional studies are essential to verify its efficacy. Furthermore, UA derivatives appear to have a beneficial impact on the cardiovascular system. This review aims to summarize recent findings on beneficial effects of UA that may make it a promising candidate for clinical trials for the management of CVDs.
format	article
author	Jakub Erdmann Marcin Kujaciński Michał Wiciński
author_facet	Jakub Erdmann Marcin Kujaciński Michał Wiciński
author_sort	Jakub Erdmann
title	Beneficial Effects of Ursolic Acid and Its Derivatives—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions
title_short	Beneficial Effects of Ursolic Acid and Its Derivatives—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions
title_full	Beneficial Effects of Ursolic Acid and Its Derivatives—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions
title_fullStr	Beneficial Effects of Ursolic Acid and Its Derivatives—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions
title_full_unstemmed	Beneficial Effects of Ursolic Acid and Its Derivatives—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions
title_sort	beneficial effects of ursolic acid and its derivatives—focus on potential biochemical mechanisms in cardiovascular conditions
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3a10991c74ec40a4b91dd12810b15e4c
work_keys_str_mv	AT jakuberdmann beneficialeffectsofursolicacidanditsderivativesfocusonpotentialbiochemicalmechanismsincardiovascularconditions AT marcinkujacinski beneficialeffectsofursolicacidanditsderivativesfocusonpotentialbiochemicalmechanismsincardiovascularconditions AT michałwicinski beneficialeffectsofursolicacidanditsderivativesfocusonpotentialbiochemicalmechanismsincardiovascularconditions
_version_	1718410945916567552

Beneficial Effects of Ursolic Acid and Its Derivatives—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

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