Evaluating CagA and VacA oncoproteins of Helicobacter pylori in oral potentially malignant disorders

Oral Potentially Malignant Disorders such as leukoplakia, lichenplanus, Oral Submucous Fibrosis are most commonly encountered precancerous lesions in India. Although, usage of smoking tobacco has been decreased yet incidence of oral cancer seems to be in increasing trend. Apart from tobacco many non...

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Autores principales:	Ramya Sekar, Prabhu Shankar Dhayashankar, Abirami Mathivanan, Nazargi Mahabob, Jingade Krishnojirao Dayashankara Rao, Syed Fareed Mohsin
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	cytotoxin-associated antigen a helicobacter pylori oral potentially malignant disorder vacuolating cytotoxin Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/3a10f5db8e054e2db3269ff2144b2e04
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spelling	oai:doaj.org-article:3a10f5db8e054e2db3269ff2144b2e042021-11-19T12:15:53ZEvaluating CagA and VacA oncoproteins of Helicobacter pylori in oral potentially malignant disorders0975-740610.4103/jpbs.jpbs_289_21https://doaj.org/article/3a10f5db8e054e2db3269ff2144b2e042021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1564;epage=1568;aulast=Sekarhttps://doaj.org/toc/0975-7406Oral Potentially Malignant Disorders such as leukoplakia, lichenplanus, Oral Submucous Fibrosis are most commonly encountered precancerous lesions in India. Although, usage of smoking tobacco has been decreased yet incidence of oral cancer seems to be in increasing trend. Apart from tobacco many non-tobacco causes are associated with the disease. Helicobacter pylori is a curved, flagellated bacterium that has been declared as group I carcinogen by WHO. They are proven causative agent for gastric carcinoma. They have been shown to harbour oral cavity by many authours. They produce onco-protein that causes DNA damage. CagA and VacA are such proteins that modulate certain oncogenes and tumour suppressor genes. In this study we have identified the organism from sub gingival plaque by PCR and those who harboured the organism were further subjected for identification of oncoproteins CagA and VacA by ELISA. This study shows that presence of organism in Oral leucoplakia, oral lichenplanus and Oral Submucous Fibrosis are statistically significant in comparison to control group (p>0.05). The presence of oncoproteins was also statistically significant in comparison to control group. These proteins are shown to accelerate inflammatory pathway thereby hasten the process of tumorigenesis. H.pylori infection as well the virulent strains can be diagnosed from oral cavity in the most non-invasive way at the earliestRamya SekarPrabhu Shankar DhayashankarAbirami MathivananNazargi MahabobJingade Krishnojirao Dayashankara RaoSyed Fareed MohsinWolters Kluwer Medknow Publicationsarticlecytotoxin-associated antigen ahelicobacter pylorioral potentially malignant disordervacuolating cytotoxinPharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 1564-1568 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cytotoxin-associated antigen a helicobacter pylori oral potentially malignant disorder vacuolating cytotoxin Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
spellingShingle	cytotoxin-associated antigen a helicobacter pylori oral potentially malignant disorder vacuolating cytotoxin Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 Ramya Sekar Prabhu Shankar Dhayashankar Abirami Mathivanan Nazargi Mahabob Jingade Krishnojirao Dayashankara Rao Syed Fareed Mohsin Evaluating CagA and VacA oncoproteins of Helicobacter pylori in oral potentially malignant disorders
description	Oral Potentially Malignant Disorders such as leukoplakia, lichenplanus, Oral Submucous Fibrosis are most commonly encountered precancerous lesions in India. Although, usage of smoking tobacco has been decreased yet incidence of oral cancer seems to be in increasing trend. Apart from tobacco many non-tobacco causes are associated with the disease. Helicobacter pylori is a curved, flagellated bacterium that has been declared as group I carcinogen by WHO. They are proven causative agent for gastric carcinoma. They have been shown to harbour oral cavity by many authours. They produce onco-protein that causes DNA damage. CagA and VacA are such proteins that modulate certain oncogenes and tumour suppressor genes. In this study we have identified the organism from sub gingival plaque by PCR and those who harboured the organism were further subjected for identification of oncoproteins CagA and VacA by ELISA. This study shows that presence of organism in Oral leucoplakia, oral lichenplanus and Oral Submucous Fibrosis are statistically significant in comparison to control group (p>0.05). The presence of oncoproteins was also statistically significant in comparison to control group. These proteins are shown to accelerate inflammatory pathway thereby hasten the process of tumorigenesis. H.pylori infection as well the virulent strains can be diagnosed from oral cavity in the most non-invasive way at the earliest
format	article
author	Ramya Sekar Prabhu Shankar Dhayashankar Abirami Mathivanan Nazargi Mahabob Jingade Krishnojirao Dayashankara Rao Syed Fareed Mohsin
author_facet	Ramya Sekar Prabhu Shankar Dhayashankar Abirami Mathivanan Nazargi Mahabob Jingade Krishnojirao Dayashankara Rao Syed Fareed Mohsin
author_sort	Ramya Sekar
title	Evaluating CagA and VacA oncoproteins of Helicobacter pylori in oral potentially malignant disorders
title_short	Evaluating CagA and VacA oncoproteins of Helicobacter pylori in oral potentially malignant disorders
title_full	Evaluating CagA and VacA oncoproteins of Helicobacter pylori in oral potentially malignant disorders
title_fullStr	Evaluating CagA and VacA oncoproteins of Helicobacter pylori in oral potentially malignant disorders
title_full_unstemmed	Evaluating CagA and VacA oncoproteins of Helicobacter pylori in oral potentially malignant disorders
title_sort	evaluating caga and vaca oncoproteins of helicobacter pylori in oral potentially malignant disorders
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/3a10f5db8e054e2db3269ff2144b2e04
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Evaluating CagA and VacA oncoproteins of Helicobacter pylori in oral potentially malignant disorders

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