Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE

Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE

ABSTRACT For more than a century, diabetic patients have been considered immunosuppressed due to defects in phagocytosis and microbial killing. We confirmed that diabetic mice were hypersusceptible to bacteremia caused by Gram-negative bacteria (GNB), dying at inocula nonlethal to nondiabetic mice....

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Bibliographic Details
Main Authors: Travis B. Nielsen, Paul Pantapalangkoor, Jun Yan, Brian M. Luna, Ken Dekitani, Kevin Bruhn, Brandon Tan, Justin Junus, Robert A. Bonomo, Ann Marie Schmidt, Michael Everson, Frederick Duncanson, Terence M. Doherty, Lin Lin, Brad Spellberg
Format: article
Language:EN
Published: American Society for Microbiology 2017
Subjects:
diabetes mellitus
Gram-negative bacteria
infection
inflammation
RAGE
TLR4
Microbiology
QR1-502
Online Access:https://doaj.org/article/3a117f40f0ff46a9bfb007c3c903625c
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