Protective Effects of Curcumin and its Nano-Phytosome on Carrageenan-Induced Inflammation in Mice Model: Behavioral and Biochemical Responses

Saeideh Baradaran, 1 Akbar Hajizadeh Moghaddam, 1 Sedigheh Khanjani Jelodar, 1 Nasroallah Moradi-kor 2 1Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran; 2Research Center of Physiology, Semnan University of Medical Sciences, Semnan, IranCorrespondence: Nas...

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Autores principales:	Baradaran S, Hajizadeh Moghaddam A, Khanjani Jelodar S, Moradi-kor N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	antioxidant activity inflammation mice model nano-phytosome Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/3a1390374e064534be6628d9bd91d696
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spelling	oai:doaj.org-article:3a1390374e064534be6628d9bd91d6962021-12-02T06:33:57ZProtective Effects of Curcumin and its Nano-Phytosome on Carrageenan-Induced Inflammation in Mice Model: Behavioral and Biochemical Responses1178-7031https://doaj.org/article/3a1390374e064534be6628d9bd91d6962020-01-01T00:00:00Zhttps://www.dovepress.com/protective-effects-of-curcumin-and-its-nano-phytosome-on-carrageenan-i-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Saeideh Baradaran, 1 Akbar Hajizadeh Moghaddam, 1 Sedigheh Khanjani Jelodar, 1 Nasroallah Moradi-kor 2 1Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran; 2Research Center of Physiology, Semnan University of Medical Sciences, Semnan, IranCorrespondence: Nasroallah Moradi-korResearch Center of Physiology, Semnan University of Medical Sciences, Damghan Road, P.O. Box 35195-163, Semnan, IranEmail moradikor.nasroallah@yahoo.comAkbar Hajizadeh MoghaddamDepartment of Biology, Faculty of Basic Sciences, University of Mazandaran, P.O. Box 57416-13534, Babolsar, IranEmail a.hajizadeh@umz.ac.irBackground and purpose: Natural compounds are used for prevention of inflammation. Curcumin has antioxidant and anti-inflammatory properties, and loading it into nano-phytosomes may improve its efficiency. The present study investigates the effects of curcumin and its nano-phytosome on behavioral and biochemical responses in carrageenan-induced inflammation in the mice model.Methods: The mice were divided into six groups and received oral administration of curcumin or its nano-phytosome at a dose of 15 mg/kg for seven days before the administration of carrageenan. Acute inflammation in the mice was induced by administration of carrageenan (1%) into the subplantar region of the left paw. Antioxidant activity and behavioral responses were then evaluated.Results: The results showed that the serum concentrations of antioxidant enzymes were significantly higher in the sal+sal group compared to the cara+sal group (P< 0.05). Using nanophytosome, separately and in combination with indomethacin, increased the levels of antioxidant enzymes compared to the cara+sal group (P< 0.05). Latency was significantly lower in the cara+sal group compared to the cara+sal group (P< 0.05), but it was considerably higher in other groups, especially in the cara+nano.ph.cur+indo group (P< 0.05).Conclusion: It can be stated that the nano-phytosome of curcumin could improve antioxidant and behavioral responses in inflamed mice.Keywords: antioxidant activity, inflammation, mice model, nano-phytosomeBaradaran SHajizadeh Moghaddam AKhanjani Jelodar SMoradi-kor NDove Medical Pressarticleantioxidant activityinflammationmice modelnano-phytosomePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 45-51 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidant activity inflammation mice model nano-phytosome Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	antioxidant activity inflammation mice model nano-phytosome Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Baradaran S Hajizadeh Moghaddam A Khanjani Jelodar S Moradi-kor N Protective Effects of Curcumin and its Nano-Phytosome on Carrageenan-Induced Inflammation in Mice Model: Behavioral and Biochemical Responses
description	Saeideh Baradaran, 1 Akbar Hajizadeh Moghaddam, 1 Sedigheh Khanjani Jelodar, 1 Nasroallah Moradi-kor 2 1Department of Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran; 2Research Center of Physiology, Semnan University of Medical Sciences, Semnan, IranCorrespondence: Nasroallah Moradi-korResearch Center of Physiology, Semnan University of Medical Sciences, Damghan Road, P.O. Box 35195-163, Semnan, IranEmail moradikor.nasroallah@yahoo.comAkbar Hajizadeh MoghaddamDepartment of Biology, Faculty of Basic Sciences, University of Mazandaran, P.O. Box 57416-13534, Babolsar, IranEmail a.hajizadeh@umz.ac.irBackground and purpose: Natural compounds are used for prevention of inflammation. Curcumin has antioxidant and anti-inflammatory properties, and loading it into nano-phytosomes may improve its efficiency. The present study investigates the effects of curcumin and its nano-phytosome on behavioral and biochemical responses in carrageenan-induced inflammation in the mice model.Methods: The mice were divided into six groups and received oral administration of curcumin or its nano-phytosome at a dose of 15 mg/kg for seven days before the administration of carrageenan. Acute inflammation in the mice was induced by administration of carrageenan (1%) into the subplantar region of the left paw. Antioxidant activity and behavioral responses were then evaluated.Results: The results showed that the serum concentrations of antioxidant enzymes were significantly higher in the sal+sal group compared to the cara+sal group (P< 0.05). Using nanophytosome, separately and in combination with indomethacin, increased the levels of antioxidant enzymes compared to the cara+sal group (P< 0.05). Latency was significantly lower in the cara+sal group compared to the cara+sal group (P< 0.05), but it was considerably higher in other groups, especially in the cara+nano.ph.cur+indo group (P< 0.05).Conclusion: It can be stated that the nano-phytosome of curcumin could improve antioxidant and behavioral responses in inflamed mice.Keywords: antioxidant activity, inflammation, mice model, nano-phytosome
format	article
author	Baradaran S Hajizadeh Moghaddam A Khanjani Jelodar S Moradi-kor N
author_facet	Baradaran S Hajizadeh Moghaddam A Khanjani Jelodar S Moradi-kor N
author_sort	Baradaran S
title	Protective Effects of Curcumin and its Nano-Phytosome on Carrageenan-Induced Inflammation in Mice Model: Behavioral and Biochemical Responses
title_short	Protective Effects of Curcumin and its Nano-Phytosome on Carrageenan-Induced Inflammation in Mice Model: Behavioral and Biochemical Responses
title_full	Protective Effects of Curcumin and its Nano-Phytosome on Carrageenan-Induced Inflammation in Mice Model: Behavioral and Biochemical Responses
title_fullStr	Protective Effects of Curcumin and its Nano-Phytosome on Carrageenan-Induced Inflammation in Mice Model: Behavioral and Biochemical Responses
title_full_unstemmed	Protective Effects of Curcumin and its Nano-Phytosome on Carrageenan-Induced Inflammation in Mice Model: Behavioral and Biochemical Responses
title_sort	protective effects of curcumin and its nano-phytosome on carrageenan-induced inflammation in mice model: behavioral and biochemical responses
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/3a1390374e064534be6628d9bd91d696
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Protective Effects of Curcumin and its Nano-Phytosome on Carrageenan-Induced Inflammation in Mice Model: Behavioral and Biochemical Responses

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