Clinical and biochemical phenotype of Indian children with different types of idiopathic growth hormone deficiency and their association with pituitary height on MRI

Background and Objectives: Differentiation of growth hormone deficiency (GHD) into various types has been made based on peak stimulated growth hormone levels and other hormone axis involvement. The data regarding how this classification is associated with variation in clinical and biochemical phenot...

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Autores principales:	Himanshu Sharma, Sandeep Kumar Mathur, Naincy Purwar, Rahul Sahlot, Umesh Garg, Balram Sharma
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	growth hormone deficiency (ghd) phenotype pituitary height Diseases of the endocrine glands. Clinical endocrinology RC648-665 Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/3a1456e61b5045509c36bfc3af6973ab
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spelling	oai:doaj.org-article:3a1456e61b5045509c36bfc3af6973ab2021-11-12T10:10:55ZClinical and biochemical phenotype of Indian children with different types of idiopathic growth hormone deficiency and their association with pituitary height on MRI2230-821010.4103/ijem.IJEM_55_21https://doaj.org/article/3a1456e61b5045509c36bfc3af6973ab2021-01-01T00:00:00Zhttp://www.ijem.in/article.asp?issn=2230-8210;year=2021;volume=25;issue=3;spage=232;epage=239;aulast=Sharmahttps://doaj.org/toc/2230-8210Background and Objectives: Differentiation of growth hormone deficiency (GHD) into various types has been made based on peak stimulated growth hormone levels and other hormone axis involvement. The data regarding how this classification is associated with variation in clinical and biochemical phenotype and how these findings associate with pituitary morphology remains sparse, especially in the Indian population. Therefore, we aimed to ascertain the differences in the pattern of auxological, clinical features including pituitary hypoplasia, and endocrinological profile among patients with severe GHD, partial GHD, and MPHD in the Indian population and to evaluate the association of pituitary height with various clinical and hormonal parameters. Materials and Methods: We conducted a cross-sectional study in 100 patients with idiopathic GHD. Patients were grouped into severe GHD, partial GHD, and MPHD to observe the differences in clinical, biochemical, and MRI findings. The pituitary height findings were correlated clinical and biochemical presentation. Results: MPHD subjects had a significantly higher frequency of breech delivery, neonatal jaundice, neonatal hypoglycemia, and micropenis. A significant difference was observed in the chronological age, bone age retardation (CA-BA), height SDS, weight SDS, peak GH response, IGF-1, IGF-1 SDS, and prevalence of pituitary hypoplasia, pituitary height, and pituitary height SDS among these three groups. In the composite population of GHD, pituitary height SDS was correlated with peak GH, basal IGF-I SDS, and body height SDS. Conclusion: The clinical and biochemical phenotype differs significantly among the various types of GHD. Pituitary height correlates with these findings and is helpful in further assessment of these patients.Himanshu SharmaSandeep Kumar MathurNaincy PurwarRahul SahlotUmesh GargBalram SharmaWolters Kluwer Medknow Publicationsarticlegrowth hormone deficiency (ghd)phenotypepituitary heightDiseases of the endocrine glands. Clinical endocrinologyRC648-665Diseases of the digestive system. GastroenterologyRC799-869ENIndian Journal of Endocrinology and Metabolism, Vol 25, Iss 3, Pp 232-239 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	growth hormone deficiency (ghd) phenotype pituitary height Diseases of the endocrine glands. Clinical endocrinology RC648-665 Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	growth hormone deficiency (ghd) phenotype pituitary height Diseases of the endocrine glands. Clinical endocrinology RC648-665 Diseases of the digestive system. Gastroenterology RC799-869 Himanshu Sharma Sandeep Kumar Mathur Naincy Purwar Rahul Sahlot Umesh Garg Balram Sharma Clinical and biochemical phenotype of Indian children with different types of idiopathic growth hormone deficiency and their association with pituitary height on MRI
description	Background and Objectives: Differentiation of growth hormone deficiency (GHD) into various types has been made based on peak stimulated growth hormone levels and other hormone axis involvement. The data regarding how this classification is associated with variation in clinical and biochemical phenotype and how these findings associate with pituitary morphology remains sparse, especially in the Indian population. Therefore, we aimed to ascertain the differences in the pattern of auxological, clinical features including pituitary hypoplasia, and endocrinological profile among patients with severe GHD, partial GHD, and MPHD in the Indian population and to evaluate the association of pituitary height with various clinical and hormonal parameters. Materials and Methods: We conducted a cross-sectional study in 100 patients with idiopathic GHD. Patients were grouped into severe GHD, partial GHD, and MPHD to observe the differences in clinical, biochemical, and MRI findings. The pituitary height findings were correlated clinical and biochemical presentation. Results: MPHD subjects had a significantly higher frequency of breech delivery, neonatal jaundice, neonatal hypoglycemia, and micropenis. A significant difference was observed in the chronological age, bone age retardation (CA-BA), height SDS, weight SDS, peak GH response, IGF-1, IGF-1 SDS, and prevalence of pituitary hypoplasia, pituitary height, and pituitary height SDS among these three groups. In the composite population of GHD, pituitary height SDS was correlated with peak GH, basal IGF-I SDS, and body height SDS. Conclusion: The clinical and biochemical phenotype differs significantly among the various types of GHD. Pituitary height correlates with these findings and is helpful in further assessment of these patients.
format	article
author	Himanshu Sharma Sandeep Kumar Mathur Naincy Purwar Rahul Sahlot Umesh Garg Balram Sharma
author_facet	Himanshu Sharma Sandeep Kumar Mathur Naincy Purwar Rahul Sahlot Umesh Garg Balram Sharma
author_sort	Himanshu Sharma
title	Clinical and biochemical phenotype of Indian children with different types of idiopathic growth hormone deficiency and their association with pituitary height on MRI
title_short	Clinical and biochemical phenotype of Indian children with different types of idiopathic growth hormone deficiency and their association with pituitary height on MRI
title_full	Clinical and biochemical phenotype of Indian children with different types of idiopathic growth hormone deficiency and their association with pituitary height on MRI
title_fullStr	Clinical and biochemical phenotype of Indian children with different types of idiopathic growth hormone deficiency and their association with pituitary height on MRI
title_full_unstemmed	Clinical and biochemical phenotype of Indian children with different types of idiopathic growth hormone deficiency and their association with pituitary height on MRI
title_sort	clinical and biochemical phenotype of indian children with different types of idiopathic growth hormone deficiency and their association with pituitary height on mri
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/3a1456e61b5045509c36bfc3af6973ab
work_keys_str_mv	AT himanshusharma clinicalandbiochemicalphenotypeofindianchildrenwithdifferenttypesofidiopathicgrowthhormonedeficiencyandtheirassociationwithpituitaryheightonmri AT sandeepkumarmathur clinicalandbiochemicalphenotypeofindianchildrenwithdifferenttypesofidiopathicgrowthhormonedeficiencyandtheirassociationwithpituitaryheightonmri AT naincypurwar clinicalandbiochemicalphenotypeofindianchildrenwithdifferenttypesofidiopathicgrowthhormonedeficiencyandtheirassociationwithpituitaryheightonmri AT rahulsahlot clinicalandbiochemicalphenotypeofindianchildrenwithdifferenttypesofidiopathicgrowthhormonedeficiencyandtheirassociationwithpituitaryheightonmri AT umeshgarg clinicalandbiochemicalphenotypeofindianchildrenwithdifferenttypesofidiopathicgrowthhormonedeficiencyandtheirassociationwithpituitaryheightonmri AT balramsharma clinicalandbiochemicalphenotypeofindianchildrenwithdifferenttypesofidiopathicgrowthhormonedeficiencyandtheirassociationwithpituitaryheightonmri
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Clinical and biochemical phenotype of Indian children with different types of idiopathic growth hormone deficiency and their association with pituitary height on MRI

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