Obesity: considerations about etiology, metabolism, and the use of experimental models

Luciana O Pereira-Lancha, Patricia L Campos-Ferraz, Antonio H Lancha JuniorSchool of Physical Education and Sport, University of Sao Paulo, Sao Paulo, BrazilAbstract: Studies have been conducted in order to identify the main factors that contribute to the development of obesity. The role of genetics...

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Autores principales:	Lancha Junior AH, Pereira-Lancha LO, Campos-Ferraz PL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/3a14984d72c74b2daca7d35419a2a52b
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spelling	oai:doaj.org-article:3a14984d72c74b2daca7d35419a2a52b2021-12-02T01:04:37ZObesity: considerations about etiology, metabolism, and the use of experimental models1178-7007https://doaj.org/article/3a14984d72c74b2daca7d35419a2a52b2012-04-01T00:00:00Zhttp://www.dovepress.com/obesity-considerations-about-etiology-metabolism-and-the-use-of-experi-a9652https://doaj.org/toc/1178-7007Luciana O Pereira-Lancha, Patricia L Campos-Ferraz, Antonio H Lancha JuniorSchool of Physical Education and Sport, University of Sao Paulo, Sao Paulo, BrazilAbstract: Studies have been conducted in order to identify the main factors that contribute to the development of obesity. The role of genetics has also been extensively studied. However, the substantial augmentation of obesity prevalence in the last 20 years cannot be justified only by genetic alterations that, theoretically, would have occurred in such a short time. Thus, the difference in obesity prevalence in various population groups is also related to environmental factors, especially diet and the reduction of physical activity. These aspects, interacting or not with genetic factors, could explain the excess of body fat in large proportions worldwide. This article will focus on positive energy balance, high-fat diet, alteration in appetite control hormones, insulin resistance, amino acids metabolism, and the limitation of the experimental models to address this complex issue.Keywords: obesity, diet, leptin, fat, ghrelin, experimental modelsLancha Junior AHPereira-Lancha LOCampos-Ferraz PLDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2012, Iss default, Pp 75-87 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Lancha Junior AH Pereira-Lancha LO Campos-Ferraz PL Obesity: considerations about etiology, metabolism, and the use of experimental models
description	Luciana O Pereira-Lancha, Patricia L Campos-Ferraz, Antonio H Lancha JuniorSchool of Physical Education and Sport, University of Sao Paulo, Sao Paulo, BrazilAbstract: Studies have been conducted in order to identify the main factors that contribute to the development of obesity. The role of genetics has also been extensively studied. However, the substantial augmentation of obesity prevalence in the last 20 years cannot be justified only by genetic alterations that, theoretically, would have occurred in such a short time. Thus, the difference in obesity prevalence in various population groups is also related to environmental factors, especially diet and the reduction of physical activity. These aspects, interacting or not with genetic factors, could explain the excess of body fat in large proportions worldwide. This article will focus on positive energy balance, high-fat diet, alteration in appetite control hormones, insulin resistance, amino acids metabolism, and the limitation of the experimental models to address this complex issue.Keywords: obesity, diet, leptin, fat, ghrelin, experimental models
format	article
author	Lancha Junior AH Pereira-Lancha LO Campos-Ferraz PL
author_facet	Lancha Junior AH Pereira-Lancha LO Campos-Ferraz PL
author_sort	Lancha Junior AH
title	Obesity: considerations about etiology, metabolism, and the use of experimental models
title_short	Obesity: considerations about etiology, metabolism, and the use of experimental models
title_full	Obesity: considerations about etiology, metabolism, and the use of experimental models
title_fullStr	Obesity: considerations about etiology, metabolism, and the use of experimental models
title_full_unstemmed	Obesity: considerations about etiology, metabolism, and the use of experimental models
title_sort	obesity: considerations about etiology, metabolism, and the use of experimental models
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/3a14984d72c74b2daca7d35419a2a52b
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Obesity: considerations about etiology, metabolism, and the use of experimental models

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