Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease

Pathogenic IgA1 metalloproteases block the initial host immune response by cleaving host IgA1. Using cryoEM, the authors here provide structural insights into the substrate recognition mechanism of Streptococcus pneumoniae IgA1 protease, and develop a protease-inhibiting antibody.

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Autores principales:	Zhiming Wang, Jeremy Rahkola, Jasmina S. Redzic, Ying-Chih Chi, Norman Tran, Todd Holyoak, Hongjin Zheng, Edward Janoff, Elan Eisenmesser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a150d834bc14865bfd27cc7c6569711
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spelling	oai:doaj.org-article:3a150d834bc14865bfd27cc7c65697112021-12-02T15:37:19ZMechanism and inhibition of Streptococcus pneumoniae IgA1 protease10.1038/s41467-020-19887-32041-1723https://doaj.org/article/3a150d834bc14865bfd27cc7c65697112020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19887-3https://doaj.org/toc/2041-1723Pathogenic IgA1 metalloproteases block the initial host immune response by cleaving host IgA1. Using cryoEM, the authors here provide structural insights into the substrate recognition mechanism of Streptococcus pneumoniae IgA1 protease, and develop a protease-inhibiting antibody.Zhiming WangJeremy RahkolaJasmina S. RedzicYing-Chih ChiNorman TranTodd HolyoakHongjin ZhengEdward JanoffElan EisenmesserNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhiming Wang Jeremy Rahkola Jasmina S. Redzic Ying-Chih Chi Norman Tran Todd Holyoak Hongjin Zheng Edward Janoff Elan Eisenmesser Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease
description	Pathogenic IgA1 metalloproteases block the initial host immune response by cleaving host IgA1. Using cryoEM, the authors here provide structural insights into the substrate recognition mechanism of Streptococcus pneumoniae IgA1 protease, and develop a protease-inhibiting antibody.
format	article
author	Zhiming Wang Jeremy Rahkola Jasmina S. Redzic Ying-Chih Chi Norman Tran Todd Holyoak Hongjin Zheng Edward Janoff Elan Eisenmesser
author_facet	Zhiming Wang Jeremy Rahkola Jasmina S. Redzic Ying-Chih Chi Norman Tran Todd Holyoak Hongjin Zheng Edward Janoff Elan Eisenmesser
author_sort	Zhiming Wang
title	Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease
title_short	Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease
title_full	Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease
title_fullStr	Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease
title_full_unstemmed	Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease
title_sort	mechanism and inhibition of streptococcus pneumoniae iga1 protease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3a150d834bc14865bfd27cc7c6569711
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_version_	1718386226295209984

Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease

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