Liquid-liquid phase separation induces pathogenic tau conformations in vitro

Tau plays an important role in tauopathies and undergoes liquid-liquid phase separation (LLPS). The authors show that disease-related P301L mutant and phosphomimic (S199E/S202E/T205E) tau enhance LLPS in vitro at physiological levels, and using specific antibodies, that tau LLPS leads to pathologica...

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Autores principales:	Nicholas M. Kanaan, Chelsey Hamel, Tessa Grabinski, Benjamin Combs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a16f0878afc4de9af28d4f1ab109e2c
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spelling	oai:doaj.org-article:3a16f0878afc4de9af28d4f1ab109e2c2021-12-02T15:03:03ZLiquid-liquid phase separation induces pathogenic tau conformations in vitro10.1038/s41467-020-16580-32041-1723https://doaj.org/article/3a16f0878afc4de9af28d4f1ab109e2c2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16580-3https://doaj.org/toc/2041-1723Tau plays an important role in tauopathies and undergoes liquid-liquid phase separation (LLPS). The authors show that disease-related P301L mutant and phosphomimic (S199E/S202E/T205E) tau enhance LLPS in vitro at physiological levels, and using specific antibodies, that tau LLPS leads to pathological conformations such as N-terminal exposure and oligomeric species.Nicholas M. KanaanChelsey HamelTessa GrabinskiBenjamin CombsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas M. Kanaan Chelsey Hamel Tessa Grabinski Benjamin Combs Liquid-liquid phase separation induces pathogenic tau conformations in vitro
description	Tau plays an important role in tauopathies and undergoes liquid-liquid phase separation (LLPS). The authors show that disease-related P301L mutant and phosphomimic (S199E/S202E/T205E) tau enhance LLPS in vitro at physiological levels, and using specific antibodies, that tau LLPS leads to pathological conformations such as N-terminal exposure and oligomeric species.
format	article
author	Nicholas M. Kanaan Chelsey Hamel Tessa Grabinski Benjamin Combs
author_facet	Nicholas M. Kanaan Chelsey Hamel Tessa Grabinski Benjamin Combs
author_sort	Nicholas M. Kanaan
title	Liquid-liquid phase separation induces pathogenic tau conformations in vitro
title_short	Liquid-liquid phase separation induces pathogenic tau conformations in vitro
title_full	Liquid-liquid phase separation induces pathogenic tau conformations in vitro
title_fullStr	Liquid-liquid phase separation induces pathogenic tau conformations in vitro
title_full_unstemmed	Liquid-liquid phase separation induces pathogenic tau conformations in vitro
title_sort	liquid-liquid phase separation induces pathogenic tau conformations in vitro
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3a16f0878afc4de9af28d4f1ab109e2c
work_keys_str_mv	AT nicholasmkanaan liquidliquidphaseseparationinducespathogenictauconformationsinvitro AT chelseyhamel liquidliquidphaseseparationinducespathogenictauconformationsinvitro AT tessagrabinski liquidliquidphaseseparationinducespathogenictauconformationsinvitro AT benjamincombs liquidliquidphaseseparationinducespathogenictauconformationsinvitro
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Liquid-liquid phase separation induces pathogenic tau conformations in vitro

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