Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations

Abstract The objective was to examine prospectively the association between retinal microvascular signs and development of diabetic kidney disease (DKD) in Asian and White populations. We analysed two population-based cohorts, composing of 1,221 Asians (SEED) and 703 White (WESDR) adults with diabet...

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Autores principales:	Simon Nusinovici, Charumathi Sabanayagam, Kristine E. Lee, Liang Zhang, Carol Y. Cheung, E. Shyong Tai, Gavin S. W. Tan, Ching Yu Cheng, Barbara E. K. Klein, Tien Yin Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3a173b9f5c80408690696dd2527c67f1
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spelling	oai:doaj.org-article:3a173b9f5c80408690696dd2527c67f12021-12-02T15:54:02ZRetinal microvascular signs and risk of diabetic kidney disease in asian and white populations10.1038/s41598-021-84464-72045-2322https://doaj.org/article/3a173b9f5c80408690696dd2527c67f12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84464-7https://doaj.org/toc/2045-2322Abstract The objective was to examine prospectively the association between retinal microvascular signs and development of diabetic kidney disease (DKD) in Asian and White populations. We analysed two population-based cohorts, composing of 1,221 Asians (SEED) and 703 White (WESDR) adults with diabetes. Retinal microvascular signs at baseline included vascular caliber (arteriolar—CRAE, and venular—CRVE) and diabetic retinopathy (DR). Incident cases of DKD were identified after ~ 6-year. Incident cases were defined based on eGFR in SEED and proteinuria or history of renal dialysis in WESDR. The incidence of DKD were 11.8% in SEED and 14.0% in WESDR. Wider CRAE in SEED (OR = 1.58 [1.02, 2.45]) and wider CRVE (OR = 1.69 [1.02, 2.80)) in WESDR were associated with increased risk of DKD. Presence of DR was associated with an increased risk of DKD in both cohorts (SEED: OR = 1.91 [1.21, 3.01] in SEED, WESDR: OR = 1.99 [1.18, 3.35]). Adding DR and retinal vascular calibers in the model beyond traditional risk factors led to an improvement of predictive performance of DKD risk between 1.1 and 2.4%; and improved classification (NRI 3 between 9%). Microvascular changes in the retina are longitudinally associated with risk of DKD.Simon NusinoviciCharumathi SabanayagamKristine E. LeeLiang ZhangCarol Y. CheungE. Shyong TaiGavin S. W. TanChing Yu ChengBarbara E. K. KleinTien Yin WongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Simon Nusinovici Charumathi Sabanayagam Kristine E. Lee Liang Zhang Carol Y. Cheung E. Shyong Tai Gavin S. W. Tan Ching Yu Cheng Barbara E. K. Klein Tien Yin Wong Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations
description	Abstract The objective was to examine prospectively the association between retinal microvascular signs and development of diabetic kidney disease (DKD) in Asian and White populations. We analysed two population-based cohorts, composing of 1,221 Asians (SEED) and 703 White (WESDR) adults with diabetes. Retinal microvascular signs at baseline included vascular caliber (arteriolar—CRAE, and venular—CRVE) and diabetic retinopathy (DR). Incident cases of DKD were identified after ~ 6-year. Incident cases were defined based on eGFR in SEED and proteinuria or history of renal dialysis in WESDR. The incidence of DKD were 11.8% in SEED and 14.0% in WESDR. Wider CRAE in SEED (OR = 1.58 [1.02, 2.45]) and wider CRVE (OR = 1.69 [1.02, 2.80)) in WESDR were associated with increased risk of DKD. Presence of DR was associated with an increased risk of DKD in both cohorts (SEED: OR = 1.91 [1.21, 3.01] in SEED, WESDR: OR = 1.99 [1.18, 3.35]). Adding DR and retinal vascular calibers in the model beyond traditional risk factors led to an improvement of predictive performance of DKD risk between 1.1 and 2.4%; and improved classification (NRI 3 between 9%). Microvascular changes in the retina are longitudinally associated with risk of DKD.
format	article
author	Simon Nusinovici Charumathi Sabanayagam Kristine E. Lee Liang Zhang Carol Y. Cheung E. Shyong Tai Gavin S. W. Tan Ching Yu Cheng Barbara E. K. Klein Tien Yin Wong
author_facet	Simon Nusinovici Charumathi Sabanayagam Kristine E. Lee Liang Zhang Carol Y. Cheung E. Shyong Tai Gavin S. W. Tan Ching Yu Cheng Barbara E. K. Klein Tien Yin Wong
author_sort	Simon Nusinovici
title	Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations
title_short	Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations
title_full	Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations
title_fullStr	Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations
title_full_unstemmed	Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations
title_sort	retinal microvascular signs and risk of diabetic kidney disease in asian and white populations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3a173b9f5c80408690696dd2527c67f1
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Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations

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