Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells

Genetic variants in CD36 have been associated with metabolic syndrome. Here, the authors found that lymphatic vessel integrity and lipid transport are influenced by CD36 expression, and lymphatic endothelial cell CD36 deficiency causes visceral obesity and insulin resistance, which are risk factors...

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Autores principales:	Vincenza Cifarelli, Sila Appak-Baskoy, Vivek S. Peche, Andrew Kluzak, Trevor Shew, Ramkumar Narendran, Kathryn M. Pietka, Marina Cella, Curtis W. Walls, Rafael Czepielewski, Stoyan Ivanov, Gwendalyn J. Randolph, Hellmut G. Augustin, Nada A. Abumrad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a1788eabbc94b12b24b664ef6cd4d29
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spelling	oai:doaj.org-article:3a1788eabbc94b12b24b664ef6cd4d292021-12-02T17:30:39ZVisceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells10.1038/s41467-021-23808-32041-1723https://doaj.org/article/3a1788eabbc94b12b24b664ef6cd4d292021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23808-3https://doaj.org/toc/2041-1723Genetic variants in CD36 have been associated with metabolic syndrome. Here, the authors found that lymphatic vessel integrity and lipid transport are influenced by CD36 expression, and lymphatic endothelial cell CD36 deficiency causes visceral obesity and insulin resistance, which are risk factors for metabolic syndrome and diabetes.Vincenza CifarelliSila Appak-BaskoyVivek S. PecheAndrew KluzakTrevor ShewRamkumar NarendranKathryn M. PietkaMarina CellaCurtis W. WallsRafael CzepielewskiStoyan IvanovGwendalyn J. RandolphHellmut G. AugustinNada A. AbumradNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vincenza Cifarelli Sila Appak-Baskoy Vivek S. Peche Andrew Kluzak Trevor Shew Ramkumar Narendran Kathryn M. Pietka Marina Cella Curtis W. Walls Rafael Czepielewski Stoyan Ivanov Gwendalyn J. Randolph Hellmut G. Augustin Nada A. Abumrad Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells
description	Genetic variants in CD36 have been associated with metabolic syndrome. Here, the authors found that lymphatic vessel integrity and lipid transport are influenced by CD36 expression, and lymphatic endothelial cell CD36 deficiency causes visceral obesity and insulin resistance, which are risk factors for metabolic syndrome and diabetes.
format	article
author	Vincenza Cifarelli Sila Appak-Baskoy Vivek S. Peche Andrew Kluzak Trevor Shew Ramkumar Narendran Kathryn M. Pietka Marina Cella Curtis W. Walls Rafael Czepielewski Stoyan Ivanov Gwendalyn J. Randolph Hellmut G. Augustin Nada A. Abumrad
author_facet	Vincenza Cifarelli Sila Appak-Baskoy Vivek S. Peche Andrew Kluzak Trevor Shew Ramkumar Narendran Kathryn M. Pietka Marina Cella Curtis W. Walls Rafael Czepielewski Stoyan Ivanov Gwendalyn J. Randolph Hellmut G. Augustin Nada A. Abumrad
author_sort	Vincenza Cifarelli
title	Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells
title_short	Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells
title_full	Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells
title_fullStr	Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells
title_full_unstemmed	Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells
title_sort	visceral obesity and insulin resistance associate with cd36 deletion in lymphatic endothelial cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3a1788eabbc94b12b24b664ef6cd4d29
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Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells

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