Vagus Nerve Stimulation For Treatment Resistant Depression: Case Series Of Six Patients - Retrospective Efficacy And Safety Observation After One Year Follow Up
Krzysztof Kucia,1 Wojciech Merk,1 Krzysztof Zapalowicz,2 Tomasz Medrala1 1Department of Psychiatry and Psychotherapy, School of Medicine in Katowice, Medical University of Silesia, GCM, Katowice 40-635, Poland; 2Neurosurgery Ward, GCM, Katowice 40-635, PolandCorrespondence: Krzysztof KuciaDepartment...
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2019
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| Acceso en línea: | https://doaj.org/article/3a191dc7dc414fea9c7f233662e81488 |
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| Sumario: | Krzysztof Kucia,1 Wojciech Merk,1 Krzysztof Zapalowicz,2 Tomasz Medrala1 1Department of Psychiatry and Psychotherapy, School of Medicine in Katowice, Medical University of Silesia, GCM, Katowice 40-635, Poland; 2Neurosurgery Ward, GCM, Katowice 40-635, PolandCorrespondence: Krzysztof KuciaDepartment of Psychiatry and Psychotherapy, School of Medicine in Katowice, Medical University of Silesia, GCM, ul. Ziolowa 45/47, Katowice 40-635, PolandTel +48 322059260Email krzykuc@mp.plObjective: One year observation and evaluation of the VNS (vagus nerve stimulation) efficacy and safety for patients with treatment resistant depression in Polish conditions.Methods: An open label, uncontrolled and one center retrospective study of VNS therapy was implemented with stable pharmacotherapy in 6 patients with treatment resistant depression (TRD). For the first 3 months, only VNS parameters were altered but the pharmacological treatment was unchanged and in the following 9 months, medication and VNS dosing parameters were altered according to the clinical state of the patients.Results: The baseline 24-item Hamilton Depression Rating Scale (HAMD-24) score averaged 24. Both response (>50% reduction in baseline scores) and remission rates after 3 months of treatment were only 40%. After 1 year of VNS therapy, the response rates increased to 86%. Most frequent side-effects were voice alteration (86% at 3 months of stimulation) and headaches (40%).Conclusion: VNS treatment was safe and effective in TRD patients and its efficacy increased with time. Efficacy ratings are similar to the previously reported studies using a congenial protocol.Keywords: vagus nerve stimulation, treatment resistant depression, brain stimulation |
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