Vagus Nerve Stimulation For Treatment Resistant Depression: Case Series Of Six Patients - Retrospective Efficacy And Safety Observation After One Year Follow Up

Krzysztof Kucia,1 Wojciech Merk,1 Krzysztof Zapalowicz,2 Tomasz Medrala1 1Department of Psychiatry and Psychotherapy, School of Medicine in Katowice, Medical University of Silesia, GCM, Katowice 40-635, Poland; 2Neurosurgery Ward, GCM, Katowice 40-635, PolandCorrespondence: Krzysztof KuciaDepartment...

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Autores principales:	Kucia K, Merk W, Zapalowicz K, Medrala T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	vagus nerve stimulation treatment resistant depression brain stimulation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/3a191dc7dc414fea9c7f233662e81488
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spelling	oai:doaj.org-article:3a191dc7dc414fea9c7f233662e814882021-12-02T05:38:28ZVagus Nerve Stimulation For Treatment Resistant Depression: Case Series Of Six Patients - Retrospective Efficacy And Safety Observation After One Year Follow Up1178-2021https://doaj.org/article/3a191dc7dc414fea9c7f233662e814882019-11-01T00:00:00Zhttps://www.dovepress.com/vagus-nerve-stimulation-for-treatment-resistant-depression-case-series-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Krzysztof Kucia,1 Wojciech Merk,1 Krzysztof Zapalowicz,2 Tomasz Medrala1 1Department of Psychiatry and Psychotherapy, School of Medicine in Katowice, Medical University of Silesia, GCM, Katowice 40-635, Poland; 2Neurosurgery Ward, GCM, Katowice 40-635, PolandCorrespondence: Krzysztof KuciaDepartment of Psychiatry and Psychotherapy, School of Medicine in Katowice, Medical University of Silesia, GCM, ul. Ziolowa 45/47, Katowice 40-635, PolandTel +48 322059260Email krzykuc@mp.plObjective: One year observation and evaluation of the VNS (vagus nerve stimulation) efficacy and safety for patients with treatment resistant depression in Polish conditions.Methods: An open label, uncontrolled and one center retrospective study of VNS therapy was implemented with stable pharmacotherapy in 6 patients with treatment resistant depression (TRD). For the first 3 months, only VNS parameters were altered but the pharmacological treatment was unchanged and in the following 9 months, medication and VNS dosing parameters were altered according to the clinical state of the patients.Results: The baseline 24-item Hamilton Depression Rating Scale (HAMD-24) score averaged 24. Both response (>50% reduction in baseline scores) and remission rates after 3 months of treatment were only 40%. After 1 year of VNS therapy, the response rates increased to 86%. Most frequent side-effects were voice alteration (86% at 3 months of stimulation) and headaches (40%).Conclusion: VNS treatment was safe and effective in TRD patients and its efficacy increased with time. Efficacy ratings are similar to the previously reported studies using a congenial protocol.Keywords: vagus nerve stimulation, treatment resistant depression, brain stimulationKucia KMerk WZapalowicz KMedrala TDove Medical Pressarticlevagus nerve stimulationtreatment resistant depressionbrain stimulationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 3247-3254 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	vagus nerve stimulation treatment resistant depression brain stimulation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	vagus nerve stimulation treatment resistant depression brain stimulation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kucia K Merk W Zapalowicz K Medrala T Vagus Nerve Stimulation For Treatment Resistant Depression: Case Series Of Six Patients - Retrospective Efficacy And Safety Observation After One Year Follow Up
description	Krzysztof Kucia,1 Wojciech Merk,1 Krzysztof Zapalowicz,2 Tomasz Medrala1 1Department of Psychiatry and Psychotherapy, School of Medicine in Katowice, Medical University of Silesia, GCM, Katowice 40-635, Poland; 2Neurosurgery Ward, GCM, Katowice 40-635, PolandCorrespondence: Krzysztof KuciaDepartment of Psychiatry and Psychotherapy, School of Medicine in Katowice, Medical University of Silesia, GCM, ul. Ziolowa 45/47, Katowice 40-635, PolandTel +48 322059260Email krzykuc@mp.plObjective: One year observation and evaluation of the VNS (vagus nerve stimulation) efficacy and safety for patients with treatment resistant depression in Polish conditions.Methods: An open label, uncontrolled and one center retrospective study of VNS therapy was implemented with stable pharmacotherapy in 6 patients with treatment resistant depression (TRD). For the first 3 months, only VNS parameters were altered but the pharmacological treatment was unchanged and in the following 9 months, medication and VNS dosing parameters were altered according to the clinical state of the patients.Results: The baseline 24-item Hamilton Depression Rating Scale (HAMD-24) score averaged 24. Both response (>50% reduction in baseline scores) and remission rates after 3 months of treatment were only 40%. After 1 year of VNS therapy, the response rates increased to 86%. Most frequent side-effects were voice alteration (86% at 3 months of stimulation) and headaches (40%).Conclusion: VNS treatment was safe and effective in TRD patients and its efficacy increased with time. Efficacy ratings are similar to the previously reported studies using a congenial protocol.Keywords: vagus nerve stimulation, treatment resistant depression, brain stimulation
format	article
author	Kucia K Merk W Zapalowicz K Medrala T
author_facet	Kucia K Merk W Zapalowicz K Medrala T
author_sort	Kucia K
title	Vagus Nerve Stimulation For Treatment Resistant Depression: Case Series Of Six Patients - Retrospective Efficacy And Safety Observation After One Year Follow Up
title_short	Vagus Nerve Stimulation For Treatment Resistant Depression: Case Series Of Six Patients - Retrospective Efficacy And Safety Observation After One Year Follow Up
title_full	Vagus Nerve Stimulation For Treatment Resistant Depression: Case Series Of Six Patients - Retrospective Efficacy And Safety Observation After One Year Follow Up
title_fullStr	Vagus Nerve Stimulation For Treatment Resistant Depression: Case Series Of Six Patients - Retrospective Efficacy And Safety Observation After One Year Follow Up
title_full_unstemmed	Vagus Nerve Stimulation For Treatment Resistant Depression: Case Series Of Six Patients - Retrospective Efficacy And Safety Observation After One Year Follow Up
title_sort	vagus nerve stimulation for treatment resistant depression: case series of six patients - retrospective efficacy and safety observation after one year follow up
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/3a191dc7dc414fea9c7f233662e81488
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Vagus Nerve Stimulation For Treatment Resistant Depression: Case Series Of Six Patients - Retrospective Efficacy And Safety Observation After One Year Follow Up

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