Reovirus directly engages integrin to recruit clathrin for entry into host cells

Reovirus endocytosis depends on junctional adhesion molecule A (JAM-A) and β1 integrin binding. Here, Koehler et al. use single-virus force spectroscopy and confocal microscopy to demonstrate a direct interaction between reovirus and β1 integrins via viral capsid protein λ2, which promotes clathrin...

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Auteurs principaux:	Melanie Koehler, Simon J. L. Petitjean, Jinsung Yang, Pavithra Aravamudhan, Xayathed Somoulay, Cristina Lo Giudice, Mégane A. Poncin, Andra C. Dumitru, Terence S. Dermody, David Alsteens
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/3a1ab7363b9f44ae9cb1014c0cfba8dc
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spelling	oai:doaj.org-article:3a1ab7363b9f44ae9cb1014c0cfba8dc2021-12-02T14:30:27ZReovirus directly engages integrin to recruit clathrin for entry into host cells10.1038/s41467-021-22380-02041-1723https://doaj.org/article/3a1ab7363b9f44ae9cb1014c0cfba8dc2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22380-0https://doaj.org/toc/2041-1723Reovirus endocytosis depends on junctional adhesion molecule A (JAM-A) and β1 integrin binding. Here, Koehler et al. use single-virus force spectroscopy and confocal microscopy to demonstrate a direct interaction between reovirus and β1 integrins via viral capsid protein λ2, which promotes clathrin recruitment to cell-bound reovirus.Melanie KoehlerSimon J. L. PetitjeanJinsung YangPavithra AravamudhanXayathed SomoulayCristina Lo GiudiceMégane A. PoncinAndra C. DumitruTerence S. DermodyDavid AlsteensNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Melanie Koehler Simon J. L. Petitjean Jinsung Yang Pavithra Aravamudhan Xayathed Somoulay Cristina Lo Giudice Mégane A. Poncin Andra C. Dumitru Terence S. Dermody David Alsteens Reovirus directly engages integrin to recruit clathrin for entry into host cells
description	Reovirus endocytosis depends on junctional adhesion molecule A (JAM-A) and β1 integrin binding. Here, Koehler et al. use single-virus force spectroscopy and confocal microscopy to demonstrate a direct interaction between reovirus and β1 integrins via viral capsid protein λ2, which promotes clathrin recruitment to cell-bound reovirus.
format	article
author	Melanie Koehler Simon J. L. Petitjean Jinsung Yang Pavithra Aravamudhan Xayathed Somoulay Cristina Lo Giudice Mégane A. Poncin Andra C. Dumitru Terence S. Dermody David Alsteens
author_facet	Melanie Koehler Simon J. L. Petitjean Jinsung Yang Pavithra Aravamudhan Xayathed Somoulay Cristina Lo Giudice Mégane A. Poncin Andra C. Dumitru Terence S. Dermody David Alsteens
author_sort	Melanie Koehler
title	Reovirus directly engages integrin to recruit clathrin for entry into host cells
title_short	Reovirus directly engages integrin to recruit clathrin for entry into host cells
title_full	Reovirus directly engages integrin to recruit clathrin for entry into host cells
title_fullStr	Reovirus directly engages integrin to recruit clathrin for entry into host cells
title_full_unstemmed	Reovirus directly engages integrin to recruit clathrin for entry into host cells
title_sort	reovirus directly engages integrin to recruit clathrin for entry into host cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3a1ab7363b9f44ae9cb1014c0cfba8dc
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Reovirus directly engages integrin to recruit clathrin for entry into host cells

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