Reovirus directly engages integrin to recruit clathrin for entry into host cells

Reovirus endocytosis depends on junctional adhesion molecule A (JAM-A) and β1 integrin binding. Here, Koehler et al. use single-virus force spectroscopy and confocal microscopy to demonstrate a direct interaction between reovirus and β1 integrins via viral capsid protein λ2, which promotes clathrin...

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Autores principales: Melanie Koehler, Simon J. L. Petitjean, Jinsung Yang, Pavithra Aravamudhan, Xayathed Somoulay, Cristina Lo Giudice, Mégane A. Poncin, Andra C. Dumitru, Terence S. Dermody, David Alsteens
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3a1ab7363b9f44ae9cb1014c0cfba8dc
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