Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross

Cryptic genetic variants may not individually show discernible phenotypic effects, but collectively, these polymorphisms can lead to unexpected, genetically complex traits that might be relevant to evolution and disease. Here, the authors use large yeast populations to comprehensively dissect the ge...

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Autores principales: Matthew B. Taylor, Joann Phan, Jonathan T. Lee, Madelyn McCadden, Ian M. Ehrenreich
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/3a1bf6e4df6343bc91f360692be3d312
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Sumario:Cryptic genetic variants may not individually show discernible phenotypic effects, but collectively, these polymorphisms can lead to unexpected, genetically complex traits that might be relevant to evolution and disease. Here, the authors use large yeast populations to comprehensively dissect the genetic bases of 17 independent occurrences of a phenotype that arises due to combinations of epistatically interacting cryptic variants.