Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross

Cryptic genetic variants may not individually show discernible phenotypic effects, but collectively, these polymorphisms can lead to unexpected, genetically complex traits that might be relevant to evolution and disease. Here, the authors use large yeast populations to comprehensively dissect the ge...

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Autores principales:	Matthew B. Taylor, Joann Phan, Jonathan T. Lee, Madelyn McCadden, Ian M. Ehrenreich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a1bf6e4df6343bc91f360692be3d312
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spelling	oai:doaj.org-article:3a1bf6e4df6343bc91f360692be3d3122021-12-02T14:39:29ZDiverse genetic architectures lead to the same cryptic phenotype in a yeast cross10.1038/ncomms116692041-1723https://doaj.org/article/3a1bf6e4df6343bc91f360692be3d3122016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11669https://doaj.org/toc/2041-1723Cryptic genetic variants may not individually show discernible phenotypic effects, but collectively, these polymorphisms can lead to unexpected, genetically complex traits that might be relevant to evolution and disease. Here, the authors use large yeast populations to comprehensively dissect the genetic bases of 17 independent occurrences of a phenotype that arises due to combinations of epistatically interacting cryptic variants.Matthew B. TaylorJoann PhanJonathan T. LeeMadelyn McCaddenIan M. EhrenreichNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-6 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthew B. Taylor Joann Phan Jonathan T. Lee Madelyn McCadden Ian M. Ehrenreich Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross
description	Cryptic genetic variants may not individually show discernible phenotypic effects, but collectively, these polymorphisms can lead to unexpected, genetically complex traits that might be relevant to evolution and disease. Here, the authors use large yeast populations to comprehensively dissect the genetic bases of 17 independent occurrences of a phenotype that arises due to combinations of epistatically interacting cryptic variants.
format	article
author	Matthew B. Taylor Joann Phan Jonathan T. Lee Madelyn McCadden Ian M. Ehrenreich
author_facet	Matthew B. Taylor Joann Phan Jonathan T. Lee Madelyn McCadden Ian M. Ehrenreich
author_sort	Matthew B. Taylor
title	Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross
title_short	Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross
title_full	Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross
title_fullStr	Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross
title_full_unstemmed	Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross
title_sort	diverse genetic architectures lead to the same cryptic phenotype in a yeast cross
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3a1bf6e4df6343bc91f360692be3d312
work_keys_str_mv	AT matthewbtaylor diversegeneticarchitecturesleadtothesamecrypticphenotypeinayeastcross AT joannphan diversegeneticarchitecturesleadtothesamecrypticphenotypeinayeastcross AT jonathantlee diversegeneticarchitecturesleadtothesamecrypticphenotypeinayeastcross AT madelynmccadden diversegeneticarchitecturesleadtothesamecrypticphenotypeinayeastcross AT ianmehrenreich diversegeneticarchitecturesleadtothesamecrypticphenotypeinayeastcross
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Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross

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