Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross

Cryptic genetic variants may not individually show discernible phenotypic effects, but collectively, these polymorphisms can lead to unexpected, genetically complex traits that might be relevant to evolution and disease. Here, the authors use large yeast populations to comprehensively dissect the ge...

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Autores principales: Matthew B. Taylor, Joann Phan, Jonathan T. Lee, Madelyn McCadden, Ian M. Ehrenreich
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/3a1bf6e4df6343bc91f360692be3d312
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spelling oai:doaj.org-article:3a1bf6e4df6343bc91f360692be3d3122021-12-02T14:39:29ZDiverse genetic architectures lead to the same cryptic phenotype in a yeast cross10.1038/ncomms116692041-1723https://doaj.org/article/3a1bf6e4df6343bc91f360692be3d3122016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11669https://doaj.org/toc/2041-1723Cryptic genetic variants may not individually show discernible phenotypic effects, but collectively, these polymorphisms can lead to unexpected, genetically complex traits that might be relevant to evolution and disease. Here, the authors use large yeast populations to comprehensively dissect the genetic bases of 17 independent occurrences of a phenotype that arises due to combinations of epistatically interacting cryptic variants.Matthew B. TaylorJoann PhanJonathan T. LeeMadelyn McCaddenIan M. EhrenreichNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-6 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Matthew B. Taylor
Joann Phan
Jonathan T. Lee
Madelyn McCadden
Ian M. Ehrenreich
Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross
description Cryptic genetic variants may not individually show discernible phenotypic effects, but collectively, these polymorphisms can lead to unexpected, genetically complex traits that might be relevant to evolution and disease. Here, the authors use large yeast populations to comprehensively dissect the genetic bases of 17 independent occurrences of a phenotype that arises due to combinations of epistatically interacting cryptic variants.
format article
author Matthew B. Taylor
Joann Phan
Jonathan T. Lee
Madelyn McCadden
Ian M. Ehrenreich
author_facet Matthew B. Taylor
Joann Phan
Jonathan T. Lee
Madelyn McCadden
Ian M. Ehrenreich
author_sort Matthew B. Taylor
title Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross
title_short Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross
title_full Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross
title_fullStr Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross
title_full_unstemmed Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross
title_sort diverse genetic architectures lead to the same cryptic phenotype in a yeast cross
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/3a1bf6e4df6343bc91f360692be3d312
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AT ianmehrenreich diversegeneticarchitecturesleadtothesamecrypticphenotypeinayeastcross
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