Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross
Cryptic genetic variants may not individually show discernible phenotypic effects, but collectively, these polymorphisms can lead to unexpected, genetically complex traits that might be relevant to evolution and disease. Here, the authors use large yeast populations to comprehensively dissect the ge...
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Nature Portfolio
2016
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oai:doaj.org-article:3a1bf6e4df6343bc91f360692be3d3122021-12-02T14:39:29ZDiverse genetic architectures lead to the same cryptic phenotype in a yeast cross10.1038/ncomms116692041-1723https://doaj.org/article/3a1bf6e4df6343bc91f360692be3d3122016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11669https://doaj.org/toc/2041-1723Cryptic genetic variants may not individually show discernible phenotypic effects, but collectively, these polymorphisms can lead to unexpected, genetically complex traits that might be relevant to evolution and disease. Here, the authors use large yeast populations to comprehensively dissect the genetic bases of 17 independent occurrences of a phenotype that arises due to combinations of epistatically interacting cryptic variants.Matthew B. TaylorJoann PhanJonathan T. LeeMadelyn McCaddenIan M. EhrenreichNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-6 (2016) |
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Science Q Matthew B. Taylor Joann Phan Jonathan T. Lee Madelyn McCadden Ian M. Ehrenreich Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross |
description |
Cryptic genetic variants may not individually show discernible phenotypic effects, but collectively, these polymorphisms can lead to unexpected, genetically complex traits that might be relevant to evolution and disease. Here, the authors use large yeast populations to comprehensively dissect the genetic bases of 17 independent occurrences of a phenotype that arises due to combinations of epistatically interacting cryptic variants. |
format |
article |
author |
Matthew B. Taylor Joann Phan Jonathan T. Lee Madelyn McCadden Ian M. Ehrenreich |
author_facet |
Matthew B. Taylor Joann Phan Jonathan T. Lee Madelyn McCadden Ian M. Ehrenreich |
author_sort |
Matthew B. Taylor |
title |
Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross |
title_short |
Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross |
title_full |
Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross |
title_fullStr |
Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross |
title_full_unstemmed |
Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross |
title_sort |
diverse genetic architectures lead to the same cryptic phenotype in a yeast cross |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/3a1bf6e4df6343bc91f360692be3d312 |
work_keys_str_mv |
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_version_ |
1718390585860030464 |