Psychiatric symptoms and leptin in obese patients who were bariatric surgery candidates

Te-Chang Changchien,1 Chi-Ming Tai,2 Chih-Kun Huang,3 Chia-Chang Chien,1 Yung-Chieh Yen1,4 1Department of Psychiatry, E-Da Hospital, 2Department of Internal Medicine, E-Da Hospital, 3Bariatric and Metabolic International Surgery Center, E-Da Hospital, 4School of Medicine, I-Shou University, Kaohsiu...

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Autores principales:	Changchien TC, Tai CM, Huang CK, Chien CC, Yen YC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/3a21394da75c4fddb1342b3a99314c1e
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spelling	oai:doaj.org-article:3a21394da75c4fddb1342b3a99314c1e2021-12-02T09:08:58ZPsychiatric symptoms and leptin in obese patients who were bariatric surgery candidates1178-2021https://doaj.org/article/3a21394da75c4fddb1342b3a99314c1e2015-08-01T00:00:00Zhttp://www.dovepress.com/psychiatric-symptoms-and-leptin-in-obese-patients-who-were-bariatric-s-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Te-Chang Changchien,1 Chi-Ming Tai,2 Chih-Kun Huang,3 Chia-Chang Chien,1 Yung-Chieh Yen1,4 1Department of Psychiatry, E-Da Hospital, 2Department of Internal Medicine, E-Da Hospital, 3Bariatric and Metabolic International Surgery Center, E-Da Hospital, 4School of Medicine, I-Shou University, Kaohsiung, Taiwan Objective: There is a significant relationship between obesity and common mental symptoms (depression and anxiety symptoms). But the association between depression (or anxiety symptoms) and serum leptin is still unclear and controversial, despite the growing body of evidence supporting the existence of “leptin resistance” in obese persons. So we investigated whether common mental symptoms, obesity, and the interactive effect of these two factors have a relationship with leptin in obese patients who were candidates for bariatric surgery.Methods: In all, 139 participants (mean age: 31.4 years, standard deviation: 9.3 years, 73.4% female) were enrolled at an obesity treatment center in southern Taiwan. Serum leptin levels and body mass index (BMI) were measured. The Chinese Health Questionnaire and Taiwanese Depression Questionnaire were administered. Results: The mean BMI of our participants was 39.4 kg/m2 (±6.8), and the mean leptin level was 24.5 ng/mL (±9.4). In the multivariate regression models, Chinese Health Questionnaire-by-BMI and Taiwanese Depression Questionnaire-by-BMI interaction terms remained significant predictors of leptin level (β=0.16, P<0.0001; β=0.04, P<0.0001, respectively), after adjustment for age, sex, and history of hypertension, diabetes, and hyperlipidemia, despite the inverse correlation between Chinese Health Questionnaire (or Taiwanese Depression Questionnaire) and leptin. In addition, female patients had significantly higher leptin levels than male patients.Conclusion: The present findings confirmed that the relationship between common mental symptoms and leptin is modulated by obesity in severely obese patients. Future studies should focus on further measures of leptin receptors or signaling on the basis of these interactive effects in psychiatry. Keywords: leptin, depression, anxiety, common mental disorder, obesityChangchien TCTai CMHuang CKChien CCYen YCDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2153-2158 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Changchien TC Tai CM Huang CK Chien CC Yen YC Psychiatric symptoms and leptin in obese patients who were bariatric surgery candidates
description	Te-Chang Changchien,1 Chi-Ming Tai,2 Chih-Kun Huang,3 Chia-Chang Chien,1 Yung-Chieh Yen1,4 1Department of Psychiatry, E-Da Hospital, 2Department of Internal Medicine, E-Da Hospital, 3Bariatric and Metabolic International Surgery Center, E-Da Hospital, 4School of Medicine, I-Shou University, Kaohsiung, Taiwan Objective: There is a significant relationship between obesity and common mental symptoms (depression and anxiety symptoms). But the association between depression (or anxiety symptoms) and serum leptin is still unclear and controversial, despite the growing body of evidence supporting the existence of “leptin resistance” in obese persons. So we investigated whether common mental symptoms, obesity, and the interactive effect of these two factors have a relationship with leptin in obese patients who were candidates for bariatric surgery.Methods: In all, 139 participants (mean age: 31.4 years, standard deviation: 9.3 years, 73.4% female) were enrolled at an obesity treatment center in southern Taiwan. Serum leptin levels and body mass index (BMI) were measured. The Chinese Health Questionnaire and Taiwanese Depression Questionnaire were administered. Results: The mean BMI of our participants was 39.4 kg/m2 (±6.8), and the mean leptin level was 24.5 ng/mL (±9.4). In the multivariate regression models, Chinese Health Questionnaire-by-BMI and Taiwanese Depression Questionnaire-by-BMI interaction terms remained significant predictors of leptin level (β=0.16, P<0.0001; β=0.04, P<0.0001, respectively), after adjustment for age, sex, and history of hypertension, diabetes, and hyperlipidemia, despite the inverse correlation between Chinese Health Questionnaire (or Taiwanese Depression Questionnaire) and leptin. In addition, female patients had significantly higher leptin levels than male patients.Conclusion: The present findings confirmed that the relationship between common mental symptoms and leptin is modulated by obesity in severely obese patients. Future studies should focus on further measures of leptin receptors or signaling on the basis of these interactive effects in psychiatry. Keywords: leptin, depression, anxiety, common mental disorder, obesity
format	article
author	Changchien TC Tai CM Huang CK Chien CC Yen YC
author_facet	Changchien TC Tai CM Huang CK Chien CC Yen YC
author_sort	Changchien TC
title	Psychiatric symptoms and leptin in obese patients who were bariatric surgery candidates
title_short	Psychiatric symptoms and leptin in obese patients who were bariatric surgery candidates
title_full	Psychiatric symptoms and leptin in obese patients who were bariatric surgery candidates
title_fullStr	Psychiatric symptoms and leptin in obese patients who were bariatric surgery candidates
title_full_unstemmed	Psychiatric symptoms and leptin in obese patients who were bariatric surgery candidates
title_sort	psychiatric symptoms and leptin in obese patients who were bariatric surgery candidates
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/3a21394da75c4fddb1342b3a99314c1e
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Psychiatric symptoms and leptin in obese patients who were bariatric surgery candidates

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