Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology
Members of the CHD chromatin remodeler family are implicated in human pathologies, however CHD6 remained poorly studied. Here, the authors show that CHD6 binds to and regulates autophagy and stress response genes across cell types. They identify a clinical mutation that affects its ability to recrui...
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Nature Portfolio
2021
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oai:doaj.org-article:3a21a85edc97413aa5f192b307a932672021-12-02T16:51:34ZOverarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology10.1038/s41467-021-23327-12041-1723https://doaj.org/article/3a21a85edc97413aa5f192b307a932672021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23327-1https://doaj.org/toc/2041-1723Members of the CHD chromatin remodeler family are implicated in human pathologies, however CHD6 remained poorly studied. Here, the authors show that CHD6 binds to and regulates autophagy and stress response genes across cell types. They identify a clinical mutation that affects its ability to recruit cofactors, leading to impaired autophagy induction and DNA repair.Yulia KargapolovaRizwan RehimiHülya KayseriliJoanna BrühlKonstantinos SofiadisAnne ZirkelSpiros PalikyrasAthanasia MiziYun LiGökhan YigitAlexander HoischenStefan FrankNicole RussJonathan TrautweinBregje van BonChristian GilissenMagdalena LaugschEduardo Gade GusmaoNatasa JosipovicJanine AltmüllerPeter NürnbergGernot LängstFrank J. KaiserErwan WatrinHan BrunnerAlvaro Rada-IglesiasLeo KurianBernd WollnikKarim BouazouneArgyris PapantonisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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DOAJ |
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Science Q |
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Science Q Yulia Kargapolova Rizwan Rehimi Hülya Kayserili Joanna Brühl Konstantinos Sofiadis Anne Zirkel Spiros Palikyras Athanasia Mizi Yun Li Gökhan Yigit Alexander Hoischen Stefan Frank Nicole Russ Jonathan Trautwein Bregje van Bon Christian Gilissen Magdalena Laugsch Eduardo Gade Gusmao Natasa Josipovic Janine Altmüller Peter Nürnberg Gernot Längst Frank J. Kaiser Erwan Watrin Han Brunner Alvaro Rada-Iglesias Leo Kurian Bernd Wollnik Karim Bouazoune Argyris Papantonis Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology |
| description |
Members of the CHD chromatin remodeler family are implicated in human pathologies, however CHD6 remained poorly studied. Here, the authors show that CHD6 binds to and regulates autophagy and stress response genes across cell types. They identify a clinical mutation that affects its ability to recruit cofactors, leading to impaired autophagy induction and DNA repair. |
| format |
article |
| author |
Yulia Kargapolova Rizwan Rehimi Hülya Kayserili Joanna Brühl Konstantinos Sofiadis Anne Zirkel Spiros Palikyras Athanasia Mizi Yun Li Gökhan Yigit Alexander Hoischen Stefan Frank Nicole Russ Jonathan Trautwein Bregje van Bon Christian Gilissen Magdalena Laugsch Eduardo Gade Gusmao Natasa Josipovic Janine Altmüller Peter Nürnberg Gernot Längst Frank J. Kaiser Erwan Watrin Han Brunner Alvaro Rada-Iglesias Leo Kurian Bernd Wollnik Karim Bouazoune Argyris Papantonis |
| author_facet |
Yulia Kargapolova Rizwan Rehimi Hülya Kayserili Joanna Brühl Konstantinos Sofiadis Anne Zirkel Spiros Palikyras Athanasia Mizi Yun Li Gökhan Yigit Alexander Hoischen Stefan Frank Nicole Russ Jonathan Trautwein Bregje van Bon Christian Gilissen Magdalena Laugsch Eduardo Gade Gusmao Natasa Josipovic Janine Altmüller Peter Nürnberg Gernot Längst Frank J. Kaiser Erwan Watrin Han Brunner Alvaro Rada-Iglesias Leo Kurian Bernd Wollnik Karim Bouazoune Argyris Papantonis |
| author_sort |
Yulia Kargapolova |
| title |
Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology |
| title_short |
Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology |
| title_full |
Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology |
| title_fullStr |
Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology |
| title_full_unstemmed |
Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology |
| title_sort |
overarching control of autophagy and dna damage response by chd6 revealed by modeling a rare human pathology |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/3a21a85edc97413aa5f192b307a93267 |
| work_keys_str_mv |
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